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21-11-2022 | Nerve Injury | Editorial

Imaging in autonomic failure: a window into real-time physiological mechanisms and other updates on recent autonomic research

Authors: Mitchell G. Miglis, Nicholas Larsen, Srikanth Muppidi

Published in: Clinical Autonomic Research | Issue 6/2022

Excerpt

Orthostatic intolerance is one of the characteristic features of orthostatic hypotension (OH), postural tachycardia syndrome (POTS), and neurally mediated syncope. Mechanisms of orthostatic intolerance may include decreased cerebral or systemic perfusion, increased sympathetic activity, hypocapnia, and abnormal peripheral vascular resistance; however, these mechanisms are still being defined and may differ for each patient. In their article, “Real-Time Magnetic Resonance Imaging (MRI) to Study Orthostatic Intolerance Mechanisms in Human Beings: Proof of Concept,” [1] the authors aimed to further investigate these mechanisms utilizing 3 T cardiac MRI in a 46-year-old male with pure autonomic failure. …

Gerlach DA, Maier A, Manuel J et al (2022) Real-time magnetic resonance imaging to study orthostatic intolerance mechanisms in human beings: proof of concept. J Am Heart Assoc 11(21):e026437. https://doi.org/10.1161/JAHA.122.026437 (Epub 2022 Oct 27)CrossRefPubMedPubMedCentral

Larsen NW, Stiles LE, Miglis MG (2021) Preparing for the long-haul: Autonomic complications of COVID-19. Auton Neurosci 235:102841. https://doi.org/10.1016/j.autneu.2021.102841CrossRefPubMedPubMedCentral

Campen (Linda) MC va C, Visser FC (2022) Long-Haul COVID patients: prevalence of POTS are reduced but cerebral blood flow abnormalities remain abnormal with longer disease duration. Healthcare (Basel) 10(10):2105. https://doi.org/10.3390/healthcare10102105CrossRef

Barnes MA, Carson MJ, Nair MG (2015) Non-traditional cytokines: How catecholamines and adipokines influence macrophages in immunity, metabolism and the central nervous system. Cytokine 72(2):210–219. https://doi.org/10.1016/j.cyto.2015.01.008CrossRefPubMedPubMedCentral

van Campen (Linda) MC C, Verheugt FWA, Rowe PC, Visser FC (2020) Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: a quantitative, controlled study using doppler echography. Clin Neurophysiol Pract 5:50–58. https://doi.org/10.1016/j.cnp.2020.01.003CrossRef

Tereshenko V, Dotzauer DC, Luft M et al (2022) Autonomic nerve fibers aberrantly reinnervate denervated facial muscles and alter muscle fiber population. J Neurosci 42:8297–8307. https://doi.org/10.1523/JNEUROSCI.0670-22.2022CrossRefPubMedPubMedCentral

Blum JA, Klemm S, Shadrach JL et al (2021) Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons. Nat Neurosci 24(4):572–583. https://doi.org/10.1038/s41593-020-00795-0CrossRefPubMedPubMedCentral

Title: Imaging in autonomic failure: a window into real-time physiological mechanisms and other updates on recent autonomic research
Authors: Mitchell G. Miglis
Nicholas Larsen
Srikanth Muppidi
Publication date: 21-11-2022
Publisher: Springer Berlin Heidelberg
Keywords: Nerve Injury
Cranial MRI
Hypotension
Post-COVID Syndrome
Hypotension
Published in: Clinical Autonomic Research / Issue 6/2022
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI: https://doi.org/10.1007/s10286-022-00910-0

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Imaging in autonomic failure: a window into real-time physiological mechanisms and other updates on recent autonomic research

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