Top

European Journal of Nutrition

Published in:

01-08-2020 | Original Contribution

Neonatal vitamin D levels and cognitive ability in young adulthood

Authors: Ina Olmer Specht, Janet Janbek, Fanney Thorsteinsdottir, Peder Frederiksen, Berit L. Heitmann

Published in: European Journal of Nutrition | Issue 5/2020

Abstract

Purpose

Intelligence has a strong influence on life capability, and thus, identifying early modifiable risk factors related to cognitive ability is of major public health interest. During pregnancy, vitamin D is transported from the mother to the fetus through the placenta in the form of 25-hydroxyvitamin D (25(OH)D). Levels of 25(OH)D have in some studies been associated with childhood neurodevelopment; however, results from all studies are not in agreement. We investigated if neonatal 25(OH)D₃ concentrations were associated with Børge Priens IQ test score (BPP) in young adulthood.

Methods

In this nested cohort study, 25(OH)D₃ concentrations were measured in dried blood spots from 818 newborns. We followed the children for their IQ BPP test scores in the Danish Conscription Register, which holds information on test results from the BPP test on individuals who have been recruited for Danish mandatory military draft board examination. Using general linear models, we investigated the crude and adjusted relationship between quintiles of 25(OH)D₃ concentrations and BPP IQ test results.

Results

The study population consisted of 95.8% men, with a mean age of 19.4 years. The median and range of the neonatal 25(OH)D₃ levels were 26.2 nmol/L (0–104.7 nmol/L). The overall Wald test did not show an association between neonatal 25(OH)D₃ levels and BPP IQ scores (p = 0.23); however, individuals within the 3rd (BPP IQ = 101.0, 98.0–103.9) and 4th (BPP IQ = 101.2, 99.1–104.3) quintiles had slightly higher BPP IQ scores than individuals from the first quintile (BPP IQ = 97.6, 94.6–100.6).

Conclusions

Our results support the hypothesis that individuals with the lowest levels of neonatal vitamin D might have slightly lower BPP. However, more studies are needed with larger study populations to confirm our results.

Tau GZ, Peterson BS (2010) Normal development of brain circuits. Neuropsychopharmacology 35(1):147–168. https://doi.org/10.1038/npp.2009.115 CrossRefPubMed

Stiles J, Jernigan TL (2010) The basics of brain development. Neuropsychol Rev 20(4):327–348. https://doi.org/10.1007/s11065-010-9148-4 CrossRefPubMedPubMedCentral

Cass WA, Peters LE, Fletcher AM, Yurek DM (2012) Evoked dopamine overflow is augmented in the striatum of calcitriol treated rats. Neurochem Int 60(2):186–191. https://doi.org/10.1016/j.neuint.2011.11.010 CrossRefPubMed

Patrick RP, Ames BN (2014) Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB J 28(6):2398–2413. https://doi.org/10.1096/fj.13-246546 CrossRefPubMed

Watanabe M, Maemura K, Kanbara K, Tamayama T, Hayasaki H (2002) GABA and GABA receptors in the central nervous system and other organs. Int Rev Cytol 213:1–47CrossRefPubMed

Gaspar P, Cases O, Maroteaux L (2003) The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 4(12):1002–1012. https://doi.org/10.1038/nrn1256 CrossRefPubMed

Patrick RP, Ames BN (2015) Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior. FASEB J 29(6):2207–2222. https://doi.org/10.1096/fj.14-268342 CrossRefPubMed

Jiang P, Zhang LH, Cai HL, Li HD, Liu YP, Tang MM, Dang RL, Zhu WY, Xue Y, He X (2014) Neurochemical effects of chronic administration of calcitriol in rats. Nutrients 6(12):6048–6059. https://doi.org/10.3390/nu6126048 CrossRefPubMedPubMedCentral

10.

Neveu I, Naveilhan P, Jehan F, Baudet C, Wion D, De Luca HF, Brachet P (1994) 1,25-Dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells. Brain Res Mol Brain Res 24(1–4):70–76CrossRefPubMed

11.

Verity AN, Wyatt TL, Lee W, Hajos B, Baecker PA, Eglen RM, Johnson RM (1999) Differential regulation of glial cell line-derived neurotrophic factor (GDNF) expression in human neuroblastoma and glioblastoma cell lines. J Neurosci Res 55(2):187–197. https://doi.org/10.1002/(sici)1097-4547(19990115)55:2%3c187:aid-jnr6%3e3.0.co;2-t CrossRefPubMed

12.

Koo H, Choi BH (2001) Expression of glial cell line-derived neurotrophic factor (GDNF) in the developing human fetal brain. Int J Dev Neurosci 19(6):549–558CrossRefPubMed

13.

Murthi P, Davies-Tuck M, Lappas M, Singh H, Mockler J, Rahman R, Lim R, Leaw B, Doery J, Wallace EM, Ebeling PR (2017) Maternal 25-hydroxyvitamin D is inversely correlated with foetal serotonin. Clin Endocrinol (Oxf) 86(3):401–409. https://doi.org/10.1111/cen.13281 CrossRef

14.

Eyles D, Burne T, McGrath J (2011) Vitamin D in fetal brain development. Semin Cell Dev Biol 22(6):629–636. https://doi.org/10.1016/j.semcdb.2011.05.004 CrossRefPubMed

15.

Pet MA, Brouwer-Brolsma EM (2016) The impact of maternal vitamin d status on offspring brain development and function: a systematic review. Adv Nutr (Bethesda, MD) 7(4):665–678. https://doi.org/10.3945/an.115.010330 CrossRef

16.

Zakon HH (1998) The effects of steroid hormones on electrical activity of excitable cells. Trends Neurosci 21(5):202–207CrossRefPubMed

17.

Srivastava DP, Waters EM, Mermelstein PG, Kramar EA, Shors TJ, Liu F (2011) Rapid estrogen signaling in the brain: implications for the fine-tuning of neuronal circuitry. J Neurosci 31(45):16056–16063. https://doi.org/10.1523/jneurosci.4097-11.2011 CrossRefPubMedPubMedCentral

18.

Chklovskii DB, Mel BW, Svoboda K (2004) Cortical rewiring and information storage. Nature 431(7010):782–788. https://doi.org/10.1038/nature03012 CrossRefPubMed

19.

Garcion E, Nataf S, Berod A, Darcy F, Brachet P (1997) 1,25-Dihydroxyvitamin D3 inhibits the expression of inducible nitric oxide synthase in rat central nervous system during experimental allergic encephalomyelitis. Brain Res Mol Brain Res 45(2):255–267CrossRefPubMed

20.

Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ (2005) Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 29(1):21–30. https://doi.org/10.1016/j.jchemneu.2004.08.006 CrossRefPubMed

21.

Garcion E, Sindji L, Montero-Menei C, Andre C, Brachet P, Darcy F (1998) Expression of inducible nitric oxide synthase during rat brain inflammation: regulation by 1,25-dihydroxyvitamin D3. Glia 22(3):282–294CrossRefPubMed

22.

Ibi M, Sawada H, Nakanishi M, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A (2001) Protective effects of 1 alpha,25-(OH)(2)D(3) against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture. Neuropharmacology 40(6):761–771CrossRefPubMed

23.

de Viragh PA, Haglid KG, Celio MR (1989) Parvalbumin increases in the caudate putamen of rats with vitamin D hypervitaminosis. Proc Natl Acad Sci USA 86(10):3887–3890CrossRefPubMedPubMedCentral

24.

Brewer LD, Thibault V, Chen KC, Langub MC, Landfield PW, Porter NM (2001) Vitamin D hormone confers neuroprotection in parallel with downregulation of l-type calcium channel expression in hippocampal neurons. J Neurosci 21(1):98–108CrossRefPubMedPubMedCentral

25.

Dursun E, Gezen-Ak D, Yilmazer S (2011) A novel perspective for Alzheimer’s disease: vitamin D receptor suppression by amyloid-beta and preventing the amyloid-beta induced alterations by vitamin D in cortical neurons. J Alzheimers Dis JAD 23(2):207–219. https://doi.org/10.3233/jad-2010-101377 CrossRefPubMed

26.

Benros ME, Sorensen HJ, Nielsen PR, Nordentoft M, Mortensen PB, Petersen L (2015) The association between infections and general cognitive ability in young men—a nationwide study. PLoS One 10(5):e0124005. https://doi.org/10.1371/journal.pone.0124005 CrossRefPubMedPubMedCentral

27.

Gimeno D, Marmot MG, Singh-Manoux A (2008) Inflammatory markers and cognitive function in middle-aged adults: the Whitehall II study. Psychoneuroendocrinology 33(10):1322–1334. https://doi.org/10.1016/j.psyneuen.2008.07.006 CrossRefPubMedPubMedCentral

28.

Darling AL, Rayman MP, Steer CD, Golding J, Lanham-New SA, Bath SC (2017) Association between maternal vitamin D status in pregnancy and neurodevelopmental outcomes in childhood: results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Br J Nutr 117(12):1682–1692. https://doi.org/10.1017/s0007114517001398 CrossRefPubMedPubMedCentral

29.

Hanieh S, Ha TT, Simpson JA, Thuy TT, Khuong NC, Thoang DD, Tran TD, Tuan T, Fisher J, Biggs BA (2014) Maternal vitamin D status and infant outcomes in rural Vietnam: a prospective cohort study. PLoS One 9(6):e99005. https://doi.org/10.1371/journal.pone.0099005 CrossRefPubMedPubMedCentral

30.

Chawla D, Fuemmeler B, Benjamin-Neelon SE, Hoyo C, Murphy S, Daniels JL (2017) Early prenatal vitamin D concentrations and social–emotional development in infants. J Maternal Fetal Neonatal Med. https://doi.org/10.1080/14767058.2017.1408065 CrossRef

31.

Gould JF, Anderson AJ, Yelland LN, Smithers LG, Skeaff CM, Zhou SJ, Gibson RA, Makrides M (2017) Association of cord blood vitamin D with early childhood growth and neurodevelopment. J Paediatr Child Health 53(1):75–83. https://doi.org/10.1111/jpc.13308 CrossRefPubMed

32.

Tylavsky FA, Kocak M, Murphy LE, Graff JC, Palmer FB, Volgyi E, Diaz-Thomas AM, Ferry RJ Jr (2015) Gestational vitamin 25(OH)d status as a risk factor for receptive language development: a 24-month, longitudinal, observational study. Nutrients 7(12):9918–9930. https://doi.org/10.3390/nu7125499 CrossRefPubMedPubMedCentral

33.

Whitehouse AJ, Holt BJ, Serralha M, Holt PG, Kusel MM, Hart PH (2012) Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development. Pediatrics 129(3):485–493. https://doi.org/10.1542/peds.2011-2644 CrossRefPubMed

34.

Zhu P, Tong SL, Hao JH, Tao RX, Huang K, Hu WB, Zhou QF, Jiang XM, Tao FB (2015) Cord blood vitamin D and neurocognitive development are nonlinearly related in toddlers. J Nutr 145(6):1232–1238. https://doi.org/10.3945/jn.114.208801 CrossRefPubMed

35.

Laird E, Thurston SW, van Wijngaarden E, Shamlaye CF, Myers GJ, Davidson PW, Watson GE, McSorley EM, Mulhern MS, Yeates AJ, Ward M, McNulty H, Strain JJ (2017) Maternal vitamin D status and the relationship with neonatal anthropometric and childhood neurodevelopmental outcomes: results from the seychelles child development nutrition study. Nutrients. https://doi.org/10.3390/nu9111235 CrossRefPubMedPubMedCentral

36.

Keim SA, Bodnar LM, Klebanoff MA (2014) Maternal and cord blood 25(OH)-vitamin D concentrations in relation to child development and behaviour. Paediatr Perinat Epidemiol 28(5):434–444. https://doi.org/10.1111/ppe.12135 CrossRefPubMedPubMedCentral

37.

Daraki V, Roumeliotaki T, Koutra K, Chalkiadaki G, Katrinaki M, Kyriklaki A, Kampouri M, Margetaki K, Vafeiadi M, Papavasiliou S, Kogevinas M, Chatzi L (2018) High maternal vitamin D levels in early pregnancy may protect against behavioral difficulties at preschool age: the Rhea mother–child cohort, Crete, Greece. Eur Child Adolesc Psychiatry 27(1):79–88. https://doi.org/10.1007/s00787-017-1023-x CrossRefPubMed

38.

McCarthy EK, Murray DM, Malvisi L, Kenny LC, Hourihane JOB, Irvine AD, Kiely ME (2018) Antenatal vitamin D status is not associated with standard neurodevelopmental assessments at age 5 years in a well-characterized prospective maternal–infant cohort. J Nutr 148(10):1580–1586. https://doi.org/10.1093/jn/nxy150 CrossRefPubMed

39.

Gale CR, Robinson SM, Harvey NC, Javaid MK, Jiang B, Martyn CN, Godfrey KM, Cooper C (2008) Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 62(1):68–77. https://doi.org/10.1038/sj.ejcn.1602680 CrossRefPubMed

40.

Veena SR, Krishnaveni GV, Srinivasan K, Thajna KP, Hegde BG, Gale CR, Fall CH (2017) Association between maternal vitamin D status during pregnancy and offspring cognitive function during childhood and adolescence. Asia Pac J Clin Nutr 26(3):438–449. https://doi.org/10.6133/apjcn.032016.07 CrossRefPubMedPubMedCentral

41.

Strom M, Halldorsson TI, Hansen S, Granstrom C, Maslova E, Petersen SB, Cohen AS, Olsen SF (2014) Vitamin D measured in maternal serum and offspring neurodevelopmental outcomes: a prospective study with long-term follow-up. Ann Nutr Metab 64(3–4):254–261. https://doi.org/10.1159/000365030 CrossRefPubMed

42.

Jacobsen R, Abrahamsen B, Bauerek M, Holst C, Jensen CB, Knop J, Raymond K, Rasmussen LB, Stougaard M, Sorensen TI, Vaag AA, Heitmann BL (2013) The influence of early exposure to vitamin D for development of diseases later in life. BMC Public Health 13:515. https://doi.org/10.1186/1471-2458-13-515 CrossRefPubMedPubMedCentral

43.

Norgaard-Pedersen B, Hougaard DM (2007) Storage policies and use of the Danish Newborn Screening Biobank. J Inherit Metab Dis 30(4):530–536. https://doi.org/10.1007/s10545-007-0631-x CrossRefPubMed

44.

Eyles D, Anderson C, Ko P, Jones A, Thomas A, Burne T, Mortensen PB, Norgaard-Pedersen B, Hougaard DM, McGrath J (2009) A sensitive LC/MS/MS assay of 25OH vitamin D3 and 25OH vitamin D2 in dried blood spots. Clin Chim Acta 403(1–2):145–151. https://doi.org/10.1016/j.cca.2009.02.005 CrossRefPubMed

45.

Jacobsen R, Thorsen SU, Cohen AS, Lundqvist M, Frederiksen P, Pipper CB, Pociot F, Thygesen LC, Ascherio A, Svensson J, Heitmann BL (2016) Neonatal vitamin D status is not associated with later risk of type 1 diabetes: results from two large Danish population-based studies. Diabetologia 59(9):1871–1881. https://doi.org/10.1007/s00125-016-4002-8 CrossRefPubMed

46.

Handel MN, Frederiksen P, Cohen A, Cooper C, Heitmann BL, Abrahamsen B (2017) Neonatal vitamin D status from archived dried blood spots and future risk of fractures in childhood: results from the D-tect study, a population-based case-cohort study. Am J Clin Nutr 106(1):155–161. https://doi.org/10.3945/ajcn.116.145599 CrossRefPubMed

47.

Kayiran SM, Ozbek N, Turan M, Gurakan B (2003) Significant differences between capillary and venous complete blood counts in the neonatal period. Clin Lab Haematol 25(1):9–16CrossRefPubMed

48.

Salle BL, Glorieux FH, Delvin EE (1988) Perinatal vitamin D metabolism. Biol Neonate 54(4):181–187CrossRefPubMed

49.

Jones KS, Assar S, Harnpanich D, Bouillon R, Lambrechts D, Prentice A, Schoenmakers I (2014) 25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by DBP concentration and genotype. J Clin Endocrinol Metab 99(9):3373–3381. https://doi.org/10.1210/jc.2014-1714 CrossRefPubMedPubMedCentral

50.

Teasdale TW (2009) The Danish draft board’s intelligence test, Borge Priens Prove: psychometric properties and research applications through 50 years. Scand J Psychol 50(6):633–638. https://doi.org/10.1111/j.1467-9450.2009.00789.x CrossRefPubMed

51.

Hypponen E, Power C (2007) Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors. Am J Clin Nutr 85(3):860–868. https://doi.org/10.1093/ajcn/85.3.860 CrossRefPubMed

52.

Smith CA, Sun C, Pezic A, Rodda C, Cameron F, Allen K, Craig ME, Carlin J, Dwyer T, Lucas RM, Eyles DW, Kemp AS, Ellis JA, Ponsonby AL (2017) Determinants of neonatal vitamin D levels as measured on neonatal dried blood spot samples. Neonatology 111(2):153–161. https://doi.org/10.1159/000448680 CrossRefPubMed

53.

Moody L, Chen H, Pan YX (2017) Early-life nutritional programming of cognition—the fundamental role of epigenetic mechanisms in mediating the relation between early-life environment and learning and memory process. Adv Nutr (Bethesda, Md) 8(2):337–350. https://doi.org/10.3945/an.116.014209 CrossRef

54.

Veena SR, Gale CR, Krishnaveni GV, Kehoe SH, Srinivasan K, Fall CH (2016) Association between maternal nutritional status in pregnancy and offspring cognitive function during childhood and adolescence; a systematic review. BMC Pregnancy Childbirth 16:220. https://doi.org/10.1186/s12884-016-1011-z CrossRefPubMedPubMedCentral

55.

Basatemur E, Gardiner J, Williams C, Melhuish E, Barnes J, Sutcliffe A (2013) Maternal prepregnancy BMI and child cognition: a longitudinal cohort study. Pediatrics 131(1):56–63. https://doi.org/10.1542/peds.2012-0788 CrossRefPubMed

56.

Karras S, Paschou SA, Kandaraki E, Anagnostis P, Annweiler C, Tarlatzis BC, Hollis BW, Grant WB, Goulis DG (2016) Hypovitaminosis D in pregnancy in the Mediterranean region: a systematic review. Eur J Clin Nutr 70(9):979–986. https://doi.org/10.1038/ejcn.2016.12 CrossRefPubMed

57.

Deeny SR, van Kleef E, Bou-Antoun S, Hope RJ, Robotham JV (2015) Seasonal changes in the incidence of Escherichia coli bloodstream infection: variation with region and place of onset. Clin Microbiol Infect 21(10):924–929. https://doi.org/10.1016/j.cmi.2015.06.023 CrossRefPubMed

58.

Cordeiro CN, Tsimis M, Burd I (2015) Infections and brain development. Obstet Gynecol Surv 70(10):644–655. https://doi.org/10.1097/ogx.0000000000000236 CrossRefPubMedPubMedCentral

59.

Lips P, van Schoor NM, de Jongh RT (2014) Diet, sun, and lifestyle as determinants of vitamin D status. Ann N Y Acad Sci 1317:92–98. https://doi.org/10.1111/nyas.12443 CrossRefPubMed

60.

Garmendia ML, Corvalan C, Uauy R (2014) Assessing the public health impact of developmental origins of health and disease (DOHaD) nutrition interventions. Ann Nutr Metab 64(3–4):226–230. https://doi.org/10.1159/000365024 CrossRefPubMed

61.

Livingston LA, Happé F (2017) Conceptualising compensation in neurodevelopmental disorders: reflections from autism spectrum disorder. Neurosci Biobehav Rev 80:729–742. https://doi.org/10.1016/j.neubiorev.2017.06.005 CrossRefPubMedPubMedCentral

62.

Ajami M, Abdollahi M, Salehi F, Oldewage-Theron W, Jamshidi-Naeini Y (2018) The association between household socioeconomic status, breastfeeding, and infants’ anthropometric indices. Int J Prev Med 9:89. https://doi.org/10.4103/ijpvm.IJPVM_52_17 CrossRefPubMedPubMedCentral

63.

Brown LJ, Sear R (2017) Local environmental quality positively predicts breastfeeding in the UK’s millennium cohort study. Evol Med Public Health 1:120–135. https://doi.org/10.1093/emph/eox011 CrossRef

64.

Hidaka BH, Kerling EH, Thodosoff JM, Sullivan DK, Colombo J, Carlson SE (2016) Dietary patterns of early childhood and maternal socioeconomic status in a unique prospective sample from a randomized controlled trial of prenatal DHA supplementation. BMC Pediatr 16(1):191. https://doi.org/10.1186/s12887-016-0729-0 CrossRefPubMedPubMedCentral

65.

McGrath JJ, Eyles DW, Pedersen CB et al (2010) Neonatal vitamin d status and risk of schizophrenia: a population-based case–control study. Arch Gen Psychiatry 67(9):889–894. https://doi.org/10.1001/archgenpsychiatry.2010.110 CrossRefPubMed

66.

Holick MF (2007) Vitamin D deficiency. N Engl J Med 357(3):266–281. https://doi.org/10.1056/NEJMra070553 CrossRefPubMed

67.

Jones KS, Assar S, Prentice A, Schoenmakers I (2016) Vitamin D expenditure is not altered in pregnancy and lactation despite changes in vitamin D metabolite concentrations. Sci Rep 6:26795. https://doi.org/10.1038/srep26795 CrossRefPubMedPubMedCentral

68.

Eyles DW, Morley R, Anderson C, Ko P, Burne T, Permezel M, Mortensen PB, Norgaard-Pedersen B, Hougaard DM, McGrath JJ (2010) The utility of neonatal dried blood spots for the assessment of neonatal vitamin D status. Paediatr Perinat Epidemiol 24(3):303–308. https://doi.org/10.1111/j.1365-3016.2010.01105.x CrossRefPubMed

69.

Teasdale TW, Hartmann PV, Pedersen CH, Bertelsen M (2011) The reliability and validity of the Danish Draft Board Cognitive Ability Test: Borge Prien’s Prove. Scand J Psychol 52(2):126–130. https://doi.org/10.1111/j.1467-9450.2010.00862.x CrossRefPubMed

Title: Neonatal vitamin D levels and cognitive ability in young adulthood
Authors: Ina Olmer Specht
Janet Janbek
Fanney Thorsteinsdottir
Peder Frederiksen
Berit L. Heitmann
Publication date: 01-08-2020
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 5/2020
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-019-02042-0

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits

Illustration of figure on mountain summit/© Orapun / Stock.adobe.com, STEP AAG HeroTeaserCollection image/© Tarek / Generated with AI / Stock.adobe.com, ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 5/2020

Efficacy of F-100, diluted F-100, and infant formula as rehabilitation diet for infants aged < 6 months with severe acute malnutrition: a randomized clinical trial

Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-Plus study

Açaí (Euterpe oleracea Martius) supplementation in the diet during gestation and lactation attenuates liver steatosis in dams and protects offspring

Human milk and infant formula differentially alters the microbiota composition and functional gene relative abundance in the small and large intestines in weanling rats

Early weaning alters the thermogenic capacity of brown adipose tissue in adult male and female rats

Daily intake of wheat germ-enriched bread may promote a healthy gut bacterial microbiota: a randomised controlled trial

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

Highlights from the ACC 2024 Congress

ACC 2024 Congress Coverage