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Open Access 01-01-2019 | Review Article

Navigating the treatment landscape in multiple myeloma: which combinations to use and when?

Authors: Hartmut Goldschmidt, John Ashcroft, Zsolt Szabo, Laurent Garderet

Published in: Annals of Hematology | Issue 1/2019

Abstract

Multiple myeloma is one of the most common hematological malignancies, affecting mainly elderly patients. The treatment landscape for the management of this disease has evolved significantly over the past 15 years, and a vast array of therapeutics is now available, including immunomodulatory drugs, proteasome inhibitors, histone deacetylase inhibitors, and monoclonal antibodies. As a result, deciding which drugs to use and when, and whether these should be used in a particular order or combination, can be challenging. Although combination regimens are often associated with deeper responses and better long-term outcomes than monotherapy, and are becoming the standard of care, they may result in significant incremental toxicity; hence, a sequential approach may be more appropriate for some patients. In particular, treatment choices can vary depending on whether the patient has newly diagnosed multiple myeloma, is eligible for transplant, has relapsed and/or refractory multiple myeloma, or is considered to have high-risk disease. In this review, we discuss factors to be taken into account when making treatment decisions in each of these settings. We also briefly discuss possible therapeutic strategies involving agents that may become available in the future.

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Title: Navigating the treatment landscape in multiple myeloma: which combinations to use and when?
Authors: Hartmut Goldschmidt
John Ashcroft
Zsolt Szabo
Laurent Garderet
Publication date: 01-01-2019
Publisher: Springer Berlin Heidelberg
Published in: Annals of Hematology / Issue 1/2019
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-018-3546-8

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