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Annals of Hematology
Published in: Annals of Hematology 1/2019

01-01-2019 | Letter to the Editor

Cytogenetically cryptic insertion of PML segment into RARA on chromosome 17q resulting PML-RARA fusion in acute promyelocytic leukemia

Authors: Timothy F. Burns, Eric Y. Loo, Elizabeth M. Bengtson, Liming Bao

Published in: Annals of Hematology | Issue 1/2019

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Excerpt

Dear Editor, …
Literature
1.
Grimwade D, Biondi A, Mozziconacci MJ et al (2000) Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Francais de Cytogenetique Hematologique, Groupe de Francais d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action “Molecular Cytogenetic Diagnosis in Haematological Malignancies”. Blood 96(4):1297–1308PubMed
2.
Grimwade D, Gorman P, Duprez E et al (1997) Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia. Blood 90(12):4876–4885PubMed
3.
Campbell LJ, Oei P, Brookwell R et al (2013) FISH detection of PML-RARA fusion in ins(15;17) acute promyelocytic leukaemia depends on probe size. Biomed Res Int 2013:164501PubMedPubMedCentral
4.
Blanco EM, Curry CV, Lu XY et al (2014) Cytogenetically cryptic and FISH-negative PML/RARA rearrangement in acute promyelocytic leukemia detected only by PCR: an exceedingly rare phenomenon. Cancer Genet 207(1–2):48–49CrossRefPubMed
5.
Lafage-Pochitaloff M, Alcalay M, Brunel V et al (1995) Acute promyelocytic leukemia cases with nonreciprocal PML/RARa or RARa/PML fusion genes. Blood 85(5):1169–1174PubMed
6.
Lee GY, Christina S, Tien SL et al (2005) Acute promyelocytic leukemia with PML-RARA fusion on i(17q) and therapy-related acute myeloid leukemia. Cancer Genet Cytogenet 159(2):129–136CrossRefPubMed
7.
Burnett AK, Grimwade D, Solomon E et al (1999) Presenting white blood cell count and kinetics of molecular remission predict prognosis in acute promyelocytic leukemia treated with all-trans retinoic acid: result of the Randomized MRC Trial. Blood 93(12):4131–4143PubMed
Metadata
Title
Cytogenetically cryptic insertion of PML segment into RARA on chromosome 17q resulting PML-RARA fusion in acute promyelocytic leukemia
Authors
Timothy F. Burns
Eric Y. Loo
Elizabeth M. Bengtson
Liming Bao
Publication date
01-01-2019
Publisher
Springer Berlin Heidelberg
Published in
Annals of Hematology / Issue 1/2019
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-018-3399-1

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