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Published in: Journal of Experimental & Clinical Cancer Research 1/2021

Open Access 01-12-2021 | Review

N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies

Authors: Fenghua Tan, Mengyao Zhao, Fang Xiong, Yumin Wang, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Yi He, Lei Shi, Fuyan Wang, Bo Xiang, Ming Zhou, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong, Can Guo

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2021

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Abstract

The N6-methyladenosine (m6A) modification is a dynamic and reversible epigenetic modification, which is co-transcriptionally deposited by a methyltransferase complex, removed by a demethylase, and recognized by reader proteins. Mechanistically, m6A modification regulates the expression levels of mRNA and nocoding RNA by modulating the fate of modified RNA molecules, such as RNA splicing, nuclear transport, translation, and stability. Several studies have shown that m6A modification is dysregulated in the progression of multiple diseases, especially human tumors. We emphasized that the dysregulation of m6A modification affects different signal transduction pathways and involves in the biological processes underlying tumor cell proliferation, apoptosis, invasion and migration, and metabolic reprogramming, and discuss the effects on different cancer treatment.
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Metadata
Title
N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies
Authors
Fenghua Tan
Mengyao Zhao
Fang Xiong
Yumin Wang
Shanshan Zhang
Zhaojian Gong
Xiayu Li
Yi He
Lei Shi
Fuyan Wang
Bo Xiang
Ming Zhou
Xiaoling Li
Yong Li
Guiyuan Li
Zhaoyang Zeng
Wei Xiong
Can Guo
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2021
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/s13046-021-01952-4

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