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Journal of Experimental & Clinical Cancer Research
Published in: Journal of Experimental & Clinical Cancer Research 1/2020

01-12-2020 | Cytokines | Review

The role of microenvironment in tumor angiogenesis

Authors: Xianjie Jiang, Jie Wang, Xiangying Deng, Fang Xiong, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Ke Cao, Hao Deng, Yi He, Qianjin Liao, Bo Xiang, Ming Zhou, Can Guo, Zhaoyang Zeng, Guiyuan Li, Xiaoling Li, Wei Xiong

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2020

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Abstract

Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment—composed of tumor cells, surrounding cells, and secreted cytokines—provides a conducive environment for the growth and survival of tumors. Different components of the tumor microenvironment can regulate tumor development. In this review, we have discussed the regulatory role of the microenvironment in tumor angiogenesis. High expression of angiogenic factors and inflammatory cytokines in the tumor microenvironment, as well as hypoxia, are presumed to be the reasons for poor therapeutic efficacy of current anti-angiogenic drugs. A combination of anti-angiogenic drugs and antitumor inflammatory drugs or hypoxia inhibitors might improve the therapeutic outcome.
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Metadata
Title
The role of microenvironment in tumor angiogenesis
Authors
Xianjie Jiang
Jie Wang
Xiangying Deng
Fang Xiong
Shanshan Zhang
Zhaojian Gong
Xiayu Li
Ke Cao
Hao Deng
Yi He
Qianjin Liao
Bo Xiang
Ming Zhou
Can Guo
Zhaoyang Zeng
Guiyuan Li
Xiaoling Li
Wei Xiong
Publication date
01-12-2020
Publisher
BioMed Central
Keyword
Cytokines
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2020
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/s13046-020-01709-5

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