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BMC Cardiovascular Disorders

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Open Access 01-12-2020 | Myocardial Infarction | Research article

Intermittent hypoxia reduces infarct size in rats with acute myocardial infarction: a systematic review and meta-analysis

Authors: Ke Hu, Wei Deng, Jing Yang, Yu Wei, Chaolin Wen, Xingsheng Li, Qingwei Chen, Dazhi Ke, Guiqiong Li

Published in: BMC Cardiovascular Disorders | Issue 1/2020

Abstract

Background

To determine whether intermittent hypoxia (IH) can reduce the infarct size (IS) after acute myocardial infarction (AMI) in rats.

Methods

Articles were identified in PubMed, EMBASE and the Web of Science and were included if they evaluated the effect of IH on the changes in the infarcted area after AMI in rats.

Results

A preliminary search identified 3633 articles and 29 data sets from 23 articles (12 in vivo, 16 in vitro). The IS decreased after AMI in IH rats both in vitro (SMD -1.46, 95% CI [− 2.37, − 0.55]; I² = 85.6%, P = 0.000) and in vivo (SMD -1.43, 95% CI [− 2.05, − 0.82], I² = 73.6%, P = 0.000). Sensitivity analysis indicated that IH had a strong protective effect against myocardial infarction, and the hypoxia concentration was significantly correlated with the change in IS after AMI.

Conclusion

IH can reduce IS after AMI in rats. This effect of IH may be related to the dose of hypoxia, and the oxygen concentration may be one of the most important influencing factors.

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Title: Intermittent hypoxia reduces infarct size in rats with acute myocardial infarction: a systematic review and meta-analysis
Authors: Ke Hu
Wei Deng
Jing Yang
Yu Wei
Chaolin Wen
Xingsheng Li
Qingwei Chen
Dazhi Ke
Guiqiong Li
Publication date: 01-12-2020
Publisher: BioMed Central
Keyword: Myocardial Infarction
Published in: BMC Cardiovascular Disorders / Issue 1/2020
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-020-01702-y

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Intermittent hypoxia reduces infarct size in rats with acute myocardial infarction: a systematic review and meta-analysis

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