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Open Access 04-03-2024 | Myocardial Infarction | Review Article

Exercise Improves Heart Function after Myocardial Infarction: The Merits of AMPK

Authors: Xiaodi Zhang, Yi Zhao, Dafen Guo, Mingxian Luo, Qing Zhang, Li Zhang, Dengshen Zhang

Published in: Cardiovascular Drugs and Therapy

Abstract

Background

AMPK is considered an important protein signaling pathway that has been shown to exert prominent cardioprotective effects on the pathophysiological mechanisms of numerous diseases. Following myocardial infarction, severe impairment of cardiac function occurs, leading to complications such as heart failure and arrhythmia. Therefore, protecting the heart and improving cardiac function are important therapeutic goals after myocardial infarction. Currently, there is substantial ongoing research on exercise-centered rehabilitation training, positioning exercise training as a significant nonpharmacological approach for preventing and treating numerous cardiovascular diseases.

Objective

Previous studies have reported that exercise can activate AMPK phosphorylation and upregulate the AMPK signaling pathway to play a cardioprotective role in coronary artery disease, but the specific mechanism involved remains to be elucidated.

Conclusion

This review discusses the role and mechanism of the exercise-mediated AMPK pathway in improving postinfarction cardiac function through existing studies and describes the mechanism of exercise-induced myocardial repair of AMPK from multiple perspectives to formulate a reasonable and optimal exercise rehabilitation program for the prevention and treatment of myocardial infarction patients in the clinic.

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Title: Exercise Improves Heart Function after Myocardial Infarction: The Merits of AMPK
Authors: Xiaodi Zhang
Yi Zhao
Dafen Guo
Mingxian Luo
Qing Zhang
Li Zhang
Dengshen Zhang
Publication date: 04-03-2024
Publisher: Springer US
Keyword: Myocardial Infarction
Published in: Cardiovascular Drugs and Therapy
Print ISSN: 0920-3206
Electronic ISSN: 1573-7241
DOI: https://doi.org/10.1007/s10557-024-07564-2

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Exercise Improves Heart Function after Myocardial Infarction: The Merits of AMPK

Abstract

Background

Objective

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Abstract

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Conclusion

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ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page