Published in:
01-09-2020 | Myelography | Correspondence
Acute Encephalopathy and Cardiac Arrest Induced by Intrathecal Gadolinium Administration
Authors:
Bianca Besteher, Ha-Yeun Chung, Thomas E. Mayer, Otto W. Witte, Klaus Kirchhof, Matthias Schwab
Published in:
Clinical Neuroradiology
|
Issue 3/2020
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Excerpt
Intravenously applied gadolinium-based contrast agents (GBCA) are widely used for magnetic resonance imaging (MRI) diagnostics in all clinical disciplines. They are considered safe with overall rates of less than 2.4% of acute allergic and non-allergic reactions [
1]. Severe adverse effects, such as cardiac arrest [
2] occur in 0.0–0.03% when administered in commonly used dosages. Intrathecal use of GBCA has been used off-label for several indications, especially for diagnosis of cerebrospinal fluid (CSF) leaks and is mostly well-tolerated [
3]. This article reports an unusual case with acute onset encephalopathy and cardiac arrest following diagnostic intrathecal administration of gadobutrol. …
