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Published in: Annals of Hematology 1/2021

01-01-2021 | Myelodysplastic Syndrome | Original Article

Characterization of myelodysplastic syndromes progressing to acute lymphoblastic leukemia

Authors: Filipe Martins, Michael Kruszewski, Ilaria Scarpelli, Jacqueline Schoumans, Olivier Spertini, Michael Lübbert, Sabine Blum

Published in: Annals of Hematology | Issue 1/2021

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Abstract

Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases, with a variable probability of transformation into acute leukemia, which is, in the vast majority of cases, of myeloid lineage. Nevertheless, rare cases of acute lymphoblastic leukemia in patients with previously diagnosed MDS have been reported. We describe a series of 3 cases of MDS/CMML marked with evolution to acute lymphoblastic leukemia (ALL) and provide a comprehensive review of the 49 cases documented in the literature so far. These sporadic events have only been published as single-case reports or small series to date. Such atypical cases emphasize the possibility of major phenotypic switches arising at the leukemic stem cell (LSC) and/or early progenitor levels, as a consequence of epigenetic and genomic events driving these changes in the bone marrow niche.
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Metadata
Title
Characterization of myelodysplastic syndromes progressing to acute lymphoblastic leukemia
Authors
Filipe Martins
Michael Kruszewski
Ilaria Scarpelli
Jacqueline Schoumans
Olivier Spertini
Michael Lübbert
Sabine Blum
Publication date
01-01-2021
Publisher
Springer Berlin Heidelberg
Published in
Annals of Hematology / Issue 1/2021
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-020-04114-2

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