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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-03-2019 | Multiple Sclerosis | Neuroophthalmology

Incidence and timing of recurrence of optic neuritis

Authors: Kyung-Ah Park, Sei Yeul Oh, Ju-Hong Min, Byoung Joon Kim

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 3/2019

Abstract

Purpose

To describe the incidence and timing of recurrence in patients with optic neuritis (ON).

Methods

Medical documents of adult patients with ON were retrospectively reviewed. The incidence and timing of recurrence of an ON episode were analyzed.

Results

One hundred eleven patients with ON were included in this study. Their mean follow-up duration was 4.1 ± 3.1 years. Seven relapses occurred after intravenous methylprednisolone treatment. The estimated cumulative incidence of recurrence in either eye was 26% at 1 year, 33% at 3 years, 37% at 5 years, and 50% at 10 years after the first episode of ON. If there was no recurrence until 6 months after the first episode of ON, the next 5-year recurrence-free survival probability was 67%. If there was no recurrence until 1 year, the next 5-year survival probability was 72%. If there was no recurrence until 2 years, the next 5-year survival probability was 81%. Relapse within 1 month and the presence of neuromyelitis optica-immunoglobulin G were factors that increased the recurrence rate over time.

Conclusions

We evaluated the incidence and timing of the recurrence in patients with ON after the first episode. Lower probability of recurrence was observed in patients with longer recurrence-free follow-up period. However, monitoring for recurrence is needed even in patients with a single episode of ON due to the increasing tendency of the estimated cumulative incidence of recurrence over many years.

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Title: Incidence and timing of recurrence of optic neuritis
Authors: Kyung-Ah Park
Sei Yeul Oh
Ju-Hong Min
Byoung Joon Kim
Publication date: 01-03-2019
Publisher: Springer Berlin Heidelberg
Keywords: Multiple Sclerosis
Optic Neuritis
Neuromyelitis Optica Spectrum Disease
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 3/2019
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-018-04217-7

At a glance: The STEP trials

Springer Medicine

Incidence and timing of recurrence of optic neuritis

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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