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Journal of Cancer Research and Clinical Oncology

Published in:

01-01-2019 | Review – Cancer Research

Multidimensional communication of microRNAs and long non-coding RNAs in lung cancer

Authors: Tingting Guo, Junyao Li, Lin Zhang, Wei Hou, Rongrong Wang, Jie Zhang, Peng Gao

Published in: Journal of Cancer Research and Clinical Oncology | Issue 1/2019

Abstract

Purpose

Non-coding RNAs (ncRNAs) have been a hot topic for many years in the field of cancer research, especially miRNAs and lncRNAs. Because they play critical roles in regulating various cellular processes and are more often involved in tumorigenesis than protein-coding genes. But the cross talk between miRNAs and lncRNAs in cancer has been scarcely studied. This article aims to provide a retrospective review of the latest research on the link between miRNAs and lncRNAs in lung cancer and discusses their potential role as diagnostic biomarkers and therapeutic targets for lung cancer in clinical practice.

Methods

We reviewed literatures about ncRNAs and lung cancer from PUBMED databases in this article.

Results

As shown in our review, miRNAs and lncRNAs could represent underlying targets for diagnosis, therapy, prognosis, and drug resistence of lung cancer. By acting as ceRNAs, lncRNAs can competitively inhibit the expression levels of miRNAs, and the lncRNA/miRNA axis can contribute to tumorigenesis, metastasis, and mutidrug resistance in lung cancer via various classic signaling pathways or related proteins.

Conclusion

Based on present knowledge, ncRNAs may provide a novel perspective to understand the pathogenesis of lung cancer and could be candidates in screening of therapeutic targets for lung cancer.

Alam M, Ahmad R, Rajabi H, Kufe D (2015) MUC1-C induces the LIN28B → LET-7 → HMGA2 axis to regulate self-renewal in NSCLC. Mol Cancer Res 13:449–460. https://doi.org/10.1158/1541-7786.MCR-14-0363 CrossRefPubMed

Alexius-Lindgren M, Andersson E, Lindstedt I, Engstrom W (2014) The RECK gene and biological malignancy—its significance in angiogenesis and inhibition of matrix metalloproteinases. Anticancer Res 34:3867–3873PubMed

Ambros V (2003) MicroRNA pathways in flies and worms: growth, death, fat, stress and timing. Cell 113:673–676CrossRefPubMed

Amit D, Hochberg A (2010) Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences. J Transl Med 8:134. https://doi.org/10.1186/1479-5876-8-134 CrossRefPubMedPubMedCentral

Ayesh S et al (2002) Possible physiological role of H19. RNA Mol Carcinog 35:63–74. https://doi.org/10.1002/mc.10075 CrossRefPubMed

Bagheri A et al (2017) Altered miR-223 expression in sputum for diagnosis of non-small cell lung cancer. Avicenna J Med Biotechnol 9:189–195PubMedPubMedCentral

Basumallik N, Agarwal M (2018) Cancer, lung, small cell (oat cell). StatPearls, Treasure Island

Bortoluzzi S, Lovisa F, Gaffo E, Mussolin L (2017) Small RNAs in circulating exosomes of cancer patients: a minireview. High Throughput. https://doi.org/10.3390/ht6040013 CrossRefPubMedPubMedCentral

Brannan CI, Dees EC, Ingram RS, Tilghman SM (1990) The product of the H19 gene may function as an RNA. Mol Cell Biol 10:28–36CrossRefPubMedPubMedCentral

Brockdorff N et al (1992) The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell 71:515–526CrossRefPubMed

Brown CJ, Hendrich BD, Rupert JL, Lafreniere RG, Xing Y, Lawrence J, Willard HF (1992) The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell 71:527–542CrossRefPubMed

Calura E et al (2016) Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t (4; 14) patients. Oncotarget 7:2367–2378. https://doi.org/10.18632/oncotarget.6151 CrossRefPubMed

Cao L, Chen J, Ou B, Liu C, Zou Y, Chen Q (2017) GAS5 knockdown reduces the chemo-sensitivity of non-small cell lung cancer (NSCLC) cell to cisplatin (DDP) through regulating miR-21/PTEN axis. Biomed Pharmacother 93:570–579. https://doi.org/10.1016/j.biopha.2017.06.089 CrossRefPubMed

Carpenter S et al (2013) A long noncoding RNA mediates both activation and repression of immune response genes. Science 341:789–792. https://doi.org/10.1126/science.1240925 CrossRefPubMedPubMedCentral

Ceppi P, Mudduluru G, Kumarswamy R, Rapa I, Scagliotti GV, Papotti M, Allgayer H (2010) Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer. Mol Cancer Res 8:1207–1216. https://doi.org/10.1158/1541-7786.MCR-10-0052 CrossRefPubMed

Chaumeil J, Waters PD, Koina E, Gilbert C, Robinson TJ, Graves JA (2011) Evolution from XIST-independent to XIST-controlled X-chromosome inactivation: epigenetic modifications in distantly related mammals. PLoS One 6:e19040. https://doi.org/10.1371/journal.pone.0019040 CrossRefPubMedPubMedCentral

Chen B et al (2013) Mdig de-represses H19 large intergenic non-coding RNA (lincRNA) by down-regulating H3K9me3 and heterochromatin. Oncotarget 4:1427–1437. https://doi.org/10.18632/oncotarget.1155 CrossRefPubMedPubMedCentral

Chen Z et al (2016) cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth. J Clin Investig 126:2267–2279. https://doi.org/10.1172/JCI85250 CrossRefPubMedPubMedCentral

Chen W et al (2017) MALAT1-miR-101-SOX9 feedback loop modulates the chemo-resistance of lung cancer cell to DDP via Wnt signaling pathway. Oncotarget 8:94317–94329. https://doi.org/10.18632/oncotarget.21693 CrossRefPubMedPubMedCentral

Cheng N et al (2015) Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR-mutant non-small cell lung cancer. Oncotarget 6:23582–23593. https://doi.org/10.18632/oncotarget.4361 CrossRefPubMedPubMedCentral

Chu GCW, Lazare K, Sullivan F (2018) Serum and blood based biomarkers for lung cancer screening: a systematic review. BMC Cancer 18:181. https://doi.org/10.1186/s12885-018-4024-3 CrossRefPubMedPubMedCentral

Coccia EM, Cicala C, Charlesworth A, Ciccarelli C, Rossi GB, Philipson L, Sorrentino V (1992) Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development. Mol Cell Biol 12:3514–3521CrossRefPubMedPubMedCentral

Costinean S, Zanesi N, Pekarsky Y, Tili E, Volinia S, Heerema N, Croce CM (2006) Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci USA 103:7024–7029. https://doi.org/10.1073/pnas.0602266103 CrossRefPubMedPubMedCentral

Devesa SS, Bray F, Vizcaino AP, Parkin DM (2005) International lung cancer trends by histologic type: male: female differences diminishing and adenocarcinoma rates rising. Int J Cancer 117:294–299. https://doi.org/10.1002/ijc.21183 CrossRefPubMed

Ding CZ et al (2018) High glucose contributes to the proliferation and migration of non-small cell lung cancer cells via GAS5-TRIB3 axis. Biosci Rep. https://doi.org/10.1042/BSR20171014 CrossRefPubMedPubMedCentral

Ebrahimi F, Gopalan V, Smith RA, Lam AK (2014) miR-126 in human cancers: clinical roles and current perspectives. Exp Mol Pathol 96:98–107. https://doi.org/10.1016/j.yexmp.2013.12.004 CrossRefPubMed

Ernst C, Morton CC (2013) Identification and function of long non-coding RNA. Front Cell Neurosci 7:168. https://doi.org/10.3389/fncel.2013.00168 CrossRefPubMedPubMedCentral

Fatica A, Bozzoni I (2014) Long non-coding RNAs: new players in cell differentiation and development. Nat Rev Genet 15:7–21. https://doi.org/10.1038/nrg3606 CrossRefPubMed

Fortes P, Morris KV (2016) Long noncoding RNAs in viral infections. Virus Res 212:1–11. https://doi.org/10.1016/j.virusres.2015.10.002 CrossRefPubMed

Garcia-Dios DA et al (2018) MED12, TERT promoter and RBM15 mutations in primary and recurrent phyllodes tumours. Br J Cancer 118:277–284. https://doi.org/10.1038/bjc.2017.450 CrossRefPubMedPubMedCentral

Ge XS et al (2013) HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway. Cancer Sci 104:1675–1682. https://doi.org/10.1111/cas.12296 CrossRefPubMedPubMedCentral

Gibb EA et al (2011) Human cancer long non-coding RNA transcriptomes. PLoS One 6:e25915. https://doi.org/10.1371/journal.pone.0025915 CrossRefPubMedPubMedCentral

Grimolizzi F et al (2017) Exosomal miR-126 as a circulating biomarker in non-small-cell lung cancer regulating cancer progression. Sci Rep 7:15277. https://doi.org/10.1038/s41598-017-15475-6 CrossRefPubMedPubMedCentral

Gumireddy K et al (2013) Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step. EMBO J 32:2672–2684. https://doi.org/10.1038/emboj.2013.188 CrossRefPubMedPubMedCentral

Guo X, Gao L, Wang Y, Chiu DK, Wang T, Deng Y (2016) Advances in long noncoding RNAs: identification, structure prediction and function annotation. Brief Funct Genom 15:38–46. https://doi.org/10.1093/bfgp/elv022 CrossRef

Guttman M et al (2009) Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 458:223–227. https://doi.org/10.1038/nature07672 CrossRefPubMedPubMedCentral

Hatley ME, Patrick DM, Garcia MR, Richardson JA, Bassel-Duby R, van Rooij E, Olson EN (2010) Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell 18:282–293. https://doi.org/10.1016/j.ccr.2010.08.013 CrossRefPubMedPubMedCentral

Hu Z et al (2010) Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol 28:1721–1726. https://doi.org/10.1200/JCO.2009.24.9342 CrossRefPubMed

Hua S, Xiaotao X, Renhua G, Yongmei Y, Lianke L, Wen G, Yongqian S (2012) Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. Biomed Pharmacother 66:89–97. https://doi.org/10.1016/j.biopha.2011.09.013 CrossRefPubMed

Huang MD, Chen WM, Qi FZ, Sun M, Xu TP, Ma P, Shu YQ (2015) Long non-coding RNA TUG1 is up-regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2. Mol Cancer 14:165. https://doi.org/10.1186/s12943-015-0431-0 CrossRefPubMedPubMedCentral

Huarte M et al (2010) A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 142:409–419. https://doi.org/10.1016/j.cell.2010.06.040 CrossRefPubMedPubMedCentral

Hwang HW, Mendell JT (2006) MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 94:776–780. https://doi.org/10.1038/sj.bjc.6603023 CrossRefPubMedPubMedCentral

Iguchi T et al (2015) A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer. Anticancer Res 35:1385–1388PubMed

International Human Genome Sequencing C (2004) Finishing the euchromatic sequence of the human genome. Nature 431:931–945. https://doi.org/10.1038/nature03001 CrossRef

Inui M, Martello G, Piccolo S (2010) MicroRNA control of signal transduction. Nat Rev Mol Cell Biol 11:252–263. https://doi.org/10.1038/nrm2868 CrossRefPubMed

Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69–90. https://doi.org/10.3322/caac.20107 CrossRefPubMed

Ji P et al (2003) MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene 22:8031–8041. https://doi.org/10.1038/sj.onc.1206928 CrossRefPubMed

Jin K et al (2015) Noncoding RNAs as potential biomarkers to predict the outcome in pancreatic cancer. Drug Des Dev Ther 9:1247–1255. https://doi.org/10.2147/DDDT.S77597 CrossRef

Jin X et al (2017a) Evaluation of tumor-derived exosomal miRNA as potential diagnostic biomarkers for early-stage non-small cell lung cancer using next-generation sequencing. Clin Cancer Res 23:5311–5319. https://doi.org/10.1158/1078-0432.CCR-17-0577 CrossRefPubMed

Jin X, Guan Y, Sheng H, Liu Y (2017b) Crosstalk in competing endogenous RNA network reveals the complex molecular mechanism underlying lung cancer. Oncotarget 8:91270–91280. https://doi.org/10.18632/oncotarget.20441 CrossRefPubMedPubMedCentral

Kalluri R, Neilson EG (2003) Epithelial–mesenchymal transition and its implications for fibrosis. J Clin Investig 112:1776–1784. https://doi.org/10.1172/JCI20530 CrossRefPubMedPubMedCentral

Kanduri C (2016) Long noncoding RNAs: lessons from genomic imprinting. Biochim Biophys Acta 1859:102–111. https://doi.org/10.1016/j.bbagrm.2015.05.006 CrossRefPubMed

Kapralova KH, Franzdottir SR, Jonsson H, Snorrason SS, Jonsson ZO (2014) Patterns of miRNA expression in Arctic charr development. PLoS One 9:e106084. https://doi.org/10.1371/journal.pone.0106084 CrossRefPubMedPubMedCentral

Kim M et al (2014) Extensive sequence variation in the 3′ untranslated region of the KRAS gene in lung and ovarian cancer cases. Cell Cycle 13:1030–1040. https://doi.org/10.4161/cc.27941 CrossRefPubMedPubMedCentral

Kondo M, Takahashi T (1996) Altered genomic imprinting in the IGF2 and H19 genes in human lung cancer. Nihon Rinsho Jpn J Clin Med 54:492–496

Kondo M, Suzuki H, Ueda R, Osada H, Takagi K, Takahashi T, Takahashi T (1995) Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancers. Oncogene 10:1193–1198PubMed

Kosaka N, Iguchi H, Hagiwara K, Yoshioka Y, Takeshita F, Ochiya T (2013) Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis. J Biol Chem 288:10849–10859. https://doi.org/10.1074/jbc.M112.446831 CrossRefPubMedPubMedCentral

Kosaka N, Yoshioka Y, Fujita Y, Ochiya T (2016) Versatile roles of extracellular vesicles in cancer. J Clin Investig 126:1163–1172. https://doi.org/10.1172/JCI81130 CrossRefPubMedPubMedCentral

Kozomara A, Griffiths-Jones S (2011) miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 39:D152–D157. https://doi.org/10.1093/nar/gkq1027 CrossRefPubMed

Kruer TL, Dougherty SM, Reynolds L, Long E, de Silva T, Lockwood WW, Clem BF (2016) Expression of the lncRNA maternally expressed gene 3 (MEG3) contributes to the control of lung cancer cell proliferation by the Rb pathway. PLoS One 11:e0166363. https://doi.org/10.1371/journal.pone.0166363 CrossRefPubMedPubMedCentral

Kundu ST, Nallur S, Paranjape T, Boeke M, Weidhaas JB, Slack FJ (2012) KRAS alleles: the LCS6 3′UTR variant and KRAS coding sequence mutations in the NCI-60 panel. Cell Cycle 11:361–366. https://doi.org/10.4161/cc.11.2.18794 CrossRefPubMed

Le Thomas A, Toth KF, Aravin AA (2014) To be or not to be a piRNA: genomic origin and processing of piRNAs. Genome Biol 15:204. https://doi.org/10.1186/gb4154 CrossRefPubMedPubMedCentral

Le H et al (2017) Peripheral lung adenocarcinomas harboring epithelial growth factor receptor mutations with microRNA-135b overexpression are more likely to invade visceral pleura. Oncol Lett 14:7931–7940. https://doi.org/10.3892/ol.2017.7195 CrossRefPubMedPubMedCentral

Li X, Wu Z, Mei Q, Li X, Guo M, Fu X, Han W (2013) Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma. Br J Cancer 109:2266–2278. https://doi.org/10.1038/bjc.2013.548 CrossRefPubMedPubMedCentral

Li X et al (2015) The tumor suppressor miR-124 inhibits cell proliferation by targeting STAT3 and functions as a prognostic marker for postoperative NSCLC patients. Int J Oncol 46:798–808. https://doi.org/10.3892/ijo.2014.2786 CrossRefPubMed

Li J et al (2016) LncRNA MALAT1 exerts oncogenic functions in lung adenocarcinoma by targeting miR-204. Am J Cancer Res 6:1099–1107PubMedPubMedCentral

Li LJ, Zhao W, Tao SS, Leng RX, Fan YG, Pan HF, Ye DQ (2017a) Competitive endogenous RNA network: potential implication for systemic lupus erythematosus. Expert Opin Ther Targets 21:639–648. https://doi.org/10.1080/14728222.2017.1319938 CrossRefPubMed

Li S, Mei Z, Hu HB (2017b) The lncRNA MALAT1 contributes to non-small cell lung cancer development via modulating miR-124/STAT3 axis. J Cell Physiol. https://doi.org/10.1002/jcp.26325 CrossRefPubMedPubMedCentral

Li Y, Chen D, Gao X, Li X, Shi G (2017c) LncRNA NEAT1 regulates cell viability and invasion in esophageal squamous cell carcinoma through the miR-129/CTBP2 axis. Dis Markers. https://doi.org/10.1155/2017/5314649 CrossRefPubMedPubMedCentral

Liang WC et al (2015) The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer. Oncotarget 6:22513–22525. https://doi.org/10.18632/oncotarget.4154 CrossRefPubMedPubMedCentral

Lin Q et al (2012) A cluster of specified microRNAs in peripheral blood as biomarkers for metastatic non-small-cell lung cancer by stem-loop RT-PCR. J Cancer Res Clin Oncol 138:85–93. https://doi.org/10.1007/s00432-011-1068-z CrossRefPubMed

Lin K et al (2016) MicroRNA expression profiles predict progression and clinical outcome in lung adenocarcinoma. OncoTargets Ther 9:5679–5692. https://doi.org/10.2147/OTT.S111241 CrossRef

Liu HQ, Li Y, Irwin DM, Zhang YP, Wu DD (2014) Integrative analysis of young genes, positively selected genes and lncRNAs in the development of Drosophila melanogaster. BMC Evol Biol 14:241. https://doi.org/10.1186/s12862-014-0241-9 CrossRefPubMedPubMedCentral

Liu C, Chen Z, Fang J, Xu A, Zhang W, Wang Z (2016) H19-derived miR-675 contributes to bladder cancer cell proliferation by regulating p53 activation. Tumour Biol 37:263–270. https://doi.org/10.1007/s13277-015-3779-2 CrossRefPubMed

Liu H et al (2017) Long noncoding RNA TUG1 is a diagnostic factor in lung adenocarcinoma and suppresses apoptosis via epigenetic silencing of BAX. Oncotarget 8:101899–101910. https://doi.org/10.18632/oncotarget.22058 CrossRefPubMedPubMedCentral

Matouk IJ, Halle D, Gilon M, Hochberg A (2015) The non-coding RNAs of the H19-IGF2 imprinted loci: a focus on biological roles and therapeutic potential in lung cancer. J Transl Med 13:113. https://doi.org/10.1186/s12967-015-0467-3 CrossRefPubMedPubMedCentral

McDougall JK, Dunn AR, Jones KW (1972) In situ hybridization of adenovirus RNA and DNA. Nature 236:346–348CrossRefPubMed

Medina PP, Nolde M, Slack FJ (2010) OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature 467:86–90. https://doi.org/10.1038/nature09284 CrossRefPubMed

Meng X et al (2015) Diagnostic and prognostic potential of serum miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429 in ovarian cancer patients. Br J Cancer 113:1358–1366. https://doi.org/10.1038/bjc.2015.340 CrossRefPubMedPubMedCentral

Mercer TR, Mattick JS (2013) Structure and function of long noncoding RNAs in epigenetic regulation. Nat Struct Mol Biol 20:300–307. https://doi.org/10.1038/nsmb.2480 CrossRefPubMed

Montani F et al (2015) miR-Test: a blood test for lung cancer early detection. J Natl Cancer Inst 107:djv063. https://doi.org/10.1093/jnci/djv063 CrossRefPubMed

Nana-Sinkam SP, Geraci MW (2006) MicroRNA in lung cancer. J Thorac Oncol 1:929–931CrossRefPubMed

National Lung Screening Trial Research T et al (2011) Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 365:395–409 https://doi.org/10.1056/NEJMoa1102873 CrossRef

O’Connell RM et al (2008) Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J Exp Med 205:585–594. https://doi.org/10.1084/jem.20072108 CrossRefPubMedPubMedCentral

Papageorgiou N, Tslamandris S, Giolis A, Tousoulis D (2016) MicroRNAs in cardiovascular disease. Perspect Real Cardiol Rev 24:110–118. https://doi.org/10.1097/CRD.0000000000000078 CrossRef

Park SM, Gaur AB, Lengyel E, Peter ME (2008) The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 22:894–907. https://doi.org/10.1101/gad.1640608 CrossRefPubMedPubMedCentral

Patil DP, Chen CK, Pickering BF, Chow A, Jackson C, Guttman M, Jaffrey SR (2016) m⁶A RNA methylation promotes XIST-mediated transcriptional repression. Nature 537:369–373. https://doi.org/10.1038/nature19342 CrossRefPubMedPubMedCentral

Ponjavic J, Ponting CP, Lunter G (2007) Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. Genome Res 17:556–565. https://doi.org/10.1101/gr.6036807 CrossRefPubMedPubMedCentral

Qu TT et al (2018) PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells. BMC Cancer 18:27. https://doi.org/10.1186/s12885-017-3959-0 CrossRefPubMedPubMedCentral

Reck M, Heigener DF, Mok T, Soria JC, Rabe KF (2013) Management of non-small-cell lung cancer: recent developments. Lancet 382:709–719. https://doi.org/10.1016/S0140-6736(13)61502-0 CrossRefPubMed

Reinhart BJ et al (2000) The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403:901–906. https://doi.org/10.1038/35002607 CrossRefPubMed

Roth A, Diederichs S (2016) Long noncoding RNAs in lung cancer. Curr Top Microbiol Immunol 394:57–110. https://doi.org/10.1007/82_2015_444 CrossRefPubMed

Sato-Kuwabara Y, Melo SA, Soares FA, Calin GA (2015) The fusion of two worlds: non-coding RNAs and extracellular vesicles-diagnostic and therapeutic implications. Int J Oncol 46:17–27. https://doi.org/10.3892/ijo.2014.2712 (Review) CrossRefPubMed

Shi X, Sun M, Liu H, Yao Y, Kong R, Chen F, Song Y (2015) A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer. Mol Carcinog 54(Suppl 1):E1–E12 https://doi.org/10.1002/mc.22120 CrossRefPubMed

Shin KM et al (2016) The pri-let-7a-2 rs1143770C>T is associated with prognosis of surgically resected non-small cell lung cancer. Gene 577:148–152. https://doi.org/10.1016/j.gene.2015.11.036 CrossRefPubMed

Shuwen H, Qing Z, Yan Z, Xi Y (2018) Competitive endogenous RNA in colorectal cancer: a systematic review. Gene 645:157–162. https://doi.org/10.1016/j.gene.2017.12.036 CrossRefPubMed

Si L, Tian H, Yue W, Li L, Li S, Gao C, Qi L (2017) Potential use of microRNA-200c as a prognostic marker in non-small cell lung cancer. Oncol Lett 14:4325–4330. https://doi.org/10.3892/ol.2017.6667 CrossRefPubMedPubMedCentral

Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. CA Cancer J Clin 68:7–30. https://doi.org/10.3322/caac.21442 CrossRefPubMed

Steck E, Boeuf S, Gabler J, Werth N, Schnatzer P, Diederichs S, Richter W (2012) Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions. J Mol Med (Berl) 90:1185–1195. https://doi.org/10.1007/s00109-012-0895-y CrossRef

Su X, Xing J, Wang Z, Chen L, Cui M, Jiang B (2013) microRNAs and ceRNAs: RNA networks in pathogenesis of cancer. Chin J Cancer Res 25:235–239. https://doi.org/10.3978/j.issn.1000-9604.2013.03.08 CrossRefPubMedPubMedCentral

Su J et al (2018) Integrating circulating immunological and sputum biomarkers for the early detection of lung cancer. Biomark Cancer 10:1179299. https://doi.org/10.1177/1179299X18759297 CrossRef

Sun Y, Gregory KJ, Chen NG, Golovlev V (2012) Rapid and direct microRNA quantification by an enzymatic luminescence assay. Anal Biochem 429:11–17. https://doi.org/10.1016/j.ab.2012.06.021 CrossRefPubMedPubMedCentral

Sun SJ, Lin Q, Ma JX, Shi WW, Yang B, Li F (2017) Long non-coding RNA NEAT1 acts as oncogene in NSCLC by regulating the Wnt signaling pathway. Eur Rev Med Pharmacol Sci 21:504–510PubMed

Tan Q et al (2017) Identification of circulating long non-coding RNA GAS5 as a potential biomarker for non-small cell lung cancer diagnosisnon-small cell lung cancer, long non-coding RNA, plasma, GAS5, biomarker. Int J Oncol 50:1729–1738. https://doi.org/10.3892/ijo.2017.3925 CrossRefPubMed

Tang Y, He R, An J, Deng P, Huang L, Yang W (2017) lncRNA XIST interacts with miR-140 to modulate lung cancer growth by targeting iASPP. Oncol Rep 38:941–948. https://doi.org/10.3892/or.2017.5751 CrossRefPubMed

Terashima M, Tange S, Ishimura A, Suzuki T (2017) MEG3 long noncoding RNA contributes to the epigenetic regulation of epithelial-mesenchymal transition in lung cancer cell lines. J Biol Chem 292:82–99. https://doi.org/10.1074/jbc.M116.750950 CrossRefPubMed

Theler D, Allain FH (2015) Molecular biology: RNA modification does a regulatory two-step. Nature 518:492–493. https://doi.org/10.1038/518492a CrossRefPubMed

Tian H, Zhou C, Yang J, Li J, Gong Z (2017) Long and short noncoding RNAs in lung cancer precision medicine: opportunities challenges. Tumour Biol. https://doi.org/10.1177/1010428317697578 CrossRefPubMed

Tripathi V et al (2010) The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell 39:925–938. https://doi.org/10.1016/j.molcel.2010.08.011 CrossRefPubMedPubMedCentral

Wagner S, Ngezahayo A, Murua Escobar H, Nolte I (2014) Role of miRNA let-7 and its major targets in prostate cancer. Biomed Res Int. https://doi.org/10.1155/2014/376326 CrossRefPubMedPubMedCentral

Wang S et al (2008) The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 15:261–271. https://doi.org/10.1016/j.devcel.2008.07.002 CrossRefPubMedPubMedCentral

Wang X, Cao L, Wang Y, Wang X, Liu N, You Y (2012) Regulation of let-7 and its target oncogenes. Oncol Lett 3:955–960. https://doi.org/10.3892/ol.2012.609 (Review) CrossRefPubMedPubMedCentral

Wang L et al (2016) Targeting H19 by lentivirus-mediated RNA interference increases A549 cell migration and invasion. Exp Lung Res 42:346–353. https://doi.org/10.1080/01902148.2016.1223229 CrossRefPubMed

Wang P, Chen D, Ma H, Li Y (2017) LncRNA SNHG12 contributes to multidrug resistance through activating the MAPK/Slug pathway by sponging miR-181a in non-small cell lung cancer. Oncotarget 8:84086–84101. https://doi.org/10.18632/oncotarget.20475 CrossRefPubMedPubMedCentral

Wang Y, Yang F, Zhuang Y (2018) Identification of a progression-associated long non-coding RNA signature for predicting the prognosis of lung squamous cell carcinoma. Exp Ther Med 15:1185–1192. https://doi.org/10.3892/etm.2017.5571 CrossRefPubMed

Watanabe Y, Yamamoto M (1994) S. pombe mei2+ encodes an RNA-binding protein essential for premeiotic DNA synthesis and meiosis I, which cooperates with a novel RNA species meiRNA. Cell 78:487–498CrossRefPubMed

Wendler A, Keller D, Albrecht C, Peluso JJ, Wehling M (2011) Involvement of let-7/miR-98 microRNAs in the regulation of progesterone receptor membrane component 1 expression in ovarian cancer cells. Oncol Rep 25:273–279PubMed

Wu R et al (2014) Diagnostic value of microRNA-21 in the diagnosis of lung cancer: evidence from a meta-analysis involving 11 studies. Tumour Biol 35:8829–8836. https://doi.org/10.1007/s13277-014-2106-7 CrossRefPubMed

Xia XM, Jin WY, Shi RZ, Zhang YF, Chen J (2010) Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer. Oncol Lett 1:1045–1047. https://doi.org/10.3892/ol.2010.164 CrossRefPubMedPubMedCentral

Xia T, Liao Q, Jiang X, Shao Y, Xiao B, Xi Y, Guo J (2014) Long noncoding RNA associated-competing endogenous RNAs in gastric cancer. Sci Rep 4:6088. https://doi.org/10.1038/srep06088 CrossRefPubMedPubMedCentral

Xu L, Huang Y, Chen D, He J, Zhu W, Zhang Y, Liu X (2014) Downregulation of miR-21 increases cisplatin sensitivity of non-small-cell lung cancer. Cancer Genet 207:214–220. https://doi.org/10.1016/j.cancergen.2014.04.003 CrossRefPubMed

Xu Y et al (2015) Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma. Tumour Biol 36:1643–1651. https://doi.org/10.1007/s13277-014-2763-6 CrossRefPubMed

Yan Y, Zhang F, Fan Q, Li X, Zhou K (2014) Breast cancer-specific TRAIL expression mediated by miRNA response elements of let-7 and miR-122. Neoplasma 61:672–679. https://doi.org/10.4149/neo_2014_082 CrossRefPubMed

Yan S et al (2015) Inhibition of NADPH oxidase protects against metastasis of human lung cancer by decreasing microRNA-21. Anticancer Drugs 26:388–398. https://doi.org/10.1097/CAD.0000000000000198 CrossRefPubMed

Yang Y, Li H, Hou S, Hu B, Liu J, Wang J (2013) The noncoding RNA expression profile and the effect of lncRNA AK126698 on cisplatin resistance in non-small-cell lung cancer cell. PLoS One 8:e65309. https://doi.org/10.1371/journal.pone.0065309 CrossRefPubMedPubMedCentral

Yao D, Cui H, Zhou S, Guo L (2017) Morin inhibited lung cancer cells viability, growth, and migration by suppressing miR-135b and inducing its target CCNG2. Tumour Biol. https://doi.org/10.1177/1010428317712443 CrossRefPubMed

Yoon JH et al (2012) LincRNA-p21 suppresses target mRNA translation. Mol Cell 47:648–655. https://doi.org/10.1016/j.molcel.2012.06.027 CrossRefPubMedPubMedCentral

Yuan JH et al (2014) A long noncoding RNA activated by TGF-beta promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell 25:666–681. https://doi.org/10.1016/j.ccr.2014.03.010 CrossRefPubMed

Zhang X et al (2010) Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression. Cancer Res 70:2350–2358. https://doi.org/10.1158/0008-5472.CAN-09-3885 CrossRefPubMedPubMedCentral

Zhang Q, Geng PL, Yin P, Wang XL, Jia JP, Yao J (2013) Down-regulation of long non-coding RNA TUG1 inhibits osteosarcoma cell proliferation and promotes apoptosis. Asian Pac J Cancer Prev 14:2311–2315CrossRefPubMed

Zhang EB et al (2014a) P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression. Cell Death Dis 5:e1243. https://doi.org/10.1038/cddis.2014.201 CrossRefPubMedPubMedCentral

Zhang H et al (2014b) MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway. Stem Cells 32:2858–2868. https://doi.org/10.1002/stem.1795 CrossRefPubMed

Zhang J, Zhang B, Wang T, Wang H (2015) LncRNA MALAT1 overexpression is an unfavorable prognostic factor in human cancer: evidence from a meta-analysis. Int J Clin Exp Med 8:5499–5505PubMedPubMedCentral

Zhang E, Li W, Yin D, De W, Zhu L, Sun S, Han L (2016a) c-Myc-regulated long non-coding RNA H19 indicates a poor prognosis and affects cell proliferation in non-small-cell lung cancer. Tumour Biol 37:4007–4015. https://doi.org/10.1007/s13277-015-4185-5 CrossRefPubMed

Zhang N, Yang GQ, Shao XM, Wei L (2016b) GAS5 modulated autophagy is a mechanism modulating cisplatin sensitivity in NSCLC cells. Eur Rev Med Pharmacol Sci 20:2271–2277PubMed

Zhang J, Li Y, Dong M, Wu D (2017a) Long non-coding RNA NEAT1 regulates E2F3 expression by competitively binding to miR-377 in non-small cell lung cancer. Oncol Lett 14:4983–4988. https://doi.org/10.3892/ol.2017.6769 CrossRefPubMedPubMedCentral

Zhang R et al (2017b) Serum long non coding RNA MALAT-1 protected by exosomes is up-regulated and promotes cell proliferation and migration in non-small cell lung cancer. Biochem Biophys Res Commun 490:406–414. https://doi.org/10.1016/j.bbrc.2017.06.055 CrossRefPubMed

Zhang S et al (2017c) m⁶A demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program. Cancer Cell 31:591–606 e596. https://doi.org/10.1016/j.ccell.2017.02.013 CrossRefPubMedPubMedCentral

Zhang XN, Wang CC, Zhou J (2017d) The long noncoding RNA NEAT1 contributes to hepatocellular carcinoma development by sponging miR-485 and enhancing the expression of the STAT3. J Cell Physiol. https://doi.org/10.1002/jcp.26371 CrossRefPubMedPubMedCentral

Zhang Y et al (2017e) Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of lung cancer. Oncol Rep 37:3543–3553. https://doi.org/10.3892/or.2017.5612 CrossRefPubMed

Zhang Z et al (2017f) Down-regulation of long non-coding RNA MEG3 indicates an unfavorable prognosis in non-small cell lung cancer: evidence from the GEO database. Gene 630:49–58. https://doi.org/10.1016/j.gene.2017.08.001 CrossRefPubMed

Zhang Q, Li X, Li X, Li X, Chen Z (2018) LncRNA H19 promotes epithelial-mesenchymal transition (EMT) by targeting miR-484 in human lung cancer cells. J Cell Biochem 119:4447–4457. https://doi.org/10.1002/jcb.26537 CrossRefPubMed

Zhao H et al (2016) The lncRNA H19 interacts with miR-140 to modulate glioma growth by targeting iASPP. Arch Biochem Biophys 610:1–7. https://doi.org/10.1016/j.abb.2016.09.014 CrossRefPubMed

Zhou Q et al (2017) MicroRNAs: a novel potential biomarker for diagnosis and therapy in patients with non-small cell lung cancer. Cell Prolif. https://doi.org/10.1111/cpr.12394 CrossRefPubMedPubMedCentral

Zhu W et al (2016) Diagnostic value of serum miR-182, miR-183, miR-210, and miR-126 levels in patients with early-stage non-small cell lung cancer. PLoS One 11:e0153046. https://doi.org/10.1371/journal.pone.0153046 CrossRefPubMedPubMedCentral

Zou Y et al (2018) Long non-coding PANDAR as a novel biomarker in human cancer: a systematic review. Cell Prolif. https://doi.org/10.1111/cpr.12422 CrossRefPubMedPubMedCentral

Title: Multidimensional communication of microRNAs and long non-coding RNAs in lung cancer
Authors: Tingting Guo
Junyao Li
Lin Zhang
Wei Hou
Rongrong Wang
Jie Zhang
Peng Gao
Publication date: 01-01-2019
Publisher: Springer Berlin Heidelberg
Published in: Journal of Cancer Research and Clinical Oncology / Issue 1/2019
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-018-2767-5

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