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BMC Neurology

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Open Access 01-12-2024 | MR Angiography | Research

Dilated perivascular spaces and steno-occlusive changes in children and adults with moyamoya disease

Authors: Min-Gyu Park, Jieun Roh, Sung-Ho Ahn, Jae Wook Cho, Kyung-Pil Park, Seung Kug Baik

Published in: BMC Neurology | Issue 1/2024

Abstract

Background

Dilated perivascular spaces (DPVS), known as one of imaging markers in cerebral small vessel disease, may be found in patients with moyamoya disease (MMD). However, little is known about DPVS in MMD. The purpose of this study was to investigate the distribution pattern of dPVS in children and adults with MMD and determine whether it is related to steno-occlusive changes of MMD.

Methods

DPVS was scored in basal ganglia (BG) and white matter (WM) on T2-weighted imaging, using a validated 4-point semi-quantitative score. The degree of dPVS was classified as high (score > 2) or low (score ≤ 2) grade. The steno-occlusive changes on MR angiography (MRA) was scored using a validated MRA grading. Asymmetry of DPVS and MRA grading was defined as a difference of 1 grade or higher between hemispheres.

Results

Fifty-one patients with MMD (mean age 24.9 ± 21.1 years) were included. Forty-five (88.2%) patients had high WM-DPVS grade (degree 3 or 4). BG-DPVS was found in 72.5% of all patients and all were low grade (degree 1 or 2). The distribution patterns of DPVS degree in BG (P = 1.000) and WM (P = 0.767) were not different between child and adult groups. The asymmetry of WM-DPVS (26%) and MRA grade (42%) were significantly correlated to each other (Kendall’s tau-b = 0.604, P < 0.001).

Conclusions

DPVS of high grade in MMD is predominantly found in WM, which was not different between children and adults. The correlation between asymmetry of WM-DPVS degree and MRA grade suggests that weak cerebral artery pulsation due to steno-occlusive changes may affect WM-DPVS in MMD.

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Title: Dilated perivascular spaces and steno-occlusive changes in children and adults with moyamoya disease
Authors: Min-Gyu Park
Jieun Roh
Sung-Ho Ahn
Jae Wook Cho
Kyung-Pil Park
Seung Kug Baik
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: MR Angiography
Cerebral Small Vessel Disease
Published in: BMC Neurology / Issue 1/2024
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-023-03520-z

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Dilated perivascular spaces and steno-occlusive changes in children and adults with moyamoya disease

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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