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01-11-2010 | Review

Molecular diagnostics of gliomas: the clinical perspective

Authors: Ghazaleh Tabatabai, Roger Stupp, Martin J. van den Bent, Monika E. Hegi, Jörg C. Tonn, Wolfgang Wick, Michael Weller

Published in: Acta Neuropathologica | Issue 5/2010

Abstract

Significant progress has been made in the molecular diagnostic subtyping of brain tumors, in particular gliomas. In contrast to the classical molecular markers in this field, p53 and epidermal growth factor receptor (EGFR) status, the clinical significance of which has remained controversial, at least three important molecular markers with clinical implications have now been identified: 1p/19q codeletion, O ⁶-methylguanine methyltransferase (MGMT) promoter methylation and isocitrate dehydrogenase-1 (IDH1) mutations. All three are favorable prognostic markers. 1p/19q codeletion and IDH1 mutations are also useful to support and extend the histological classification of gliomas since they are strongly linked to oligodendroglial morphology and grade II/III gliomas, as opposed to glioblastoma, respectively. MGMT promoter methylation is the only potentially predictive marker, at least for alkylating agent chemotherapy in glioblastoma. Beyond these classical markers, the increasing repertoire of anti-angiogenic agents that are currently explored within registration trials for gliomas urgently calls for efforts to identify molecular markers that predict the benefit derived from these novel treatments, too.

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Title: Molecular diagnostics of gliomas: the clinical perspective
Authors: Ghazaleh Tabatabai
Roger Stupp
Martin J. van den Bent
Monika E. Hegi
Jörg C. Tonn
Wolfgang Wick
Michael Weller
Publication date: 01-11-2010
Publisher: Springer-Verlag
Published in: Acta Neuropathologica / Issue 5/2010
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-010-0750-6

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Molecular diagnostics of gliomas: the clinical perspective

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