Skip to main content
Top
Published in: Virology Journal 1/2008

Open Access 01-12-2008 | Debate

Migratory birds, the H5N1 influenza virus and the scientific method

Authors: Thomas P Weber, Nikolaos I Stilianakis

Published in: Virology Journal | Issue 1/2008

Login to get access

Abstract

Background

The role of migratory birds and of poultry trade in the dispersal of highly pathogenic H5N1 is still the topic of intense and controversial debate. In a recent contribution to this journal, Flint argues that the strict application of the scientific method can help to resolve this issue.

Discussion

We argue that Flint's identification of the scientific method with null hypothesis testing is misleading and counterproductive. There is far more to science than the testing of hypotheses; not only the justification, bur also the discovery of hypotheses belong to science. We also show why null hypothesis testing is weak and that Bayesian methods are a preferable approach to statistical inference. Furthermore, we criticize the analogy put forward by Flint between involuntary transport of poultry and long-distance migration.

Summary

To expect ultimate answers and unequivocal policy guidance from null hypothesis testing puts unrealistic expectations on a flawed approach to statistical inference and on science in general.
Literature
1.
go back to reference Flint PL: Applying the scientific method when assessing the influence of migratory birds on the dispersal of H5N1. Virol J 2007, 4: 132. 10.1186/1743-422X-4-132PubMedCentralCrossRefPubMed Flint PL: Applying the scientific method when assessing the influence of migratory birds on the dispersal of H5N1. Virol J 2007, 4: 132. 10.1186/1743-422X-4-132PubMedCentralCrossRefPubMed
3.
go back to reference Reichenbach H: Experience and Prediction. Chicago: The University of Chicago Press; 1938. Reichenbach H: Experience and Prediction. Chicago: The University of Chicago Press; 1938.
4.
go back to reference Hacking I: Representing and Intervening. Cambridge: Cambridge University Press; 1983.CrossRef Hacking I: Representing and Intervening. Cambridge: Cambridge University Press; 1983.CrossRef
5.
go back to reference Galison P, Stump DJ, (eds): The Disunity of Science. Stanford: Stanford University Press; 1996. Galison P, Stump DJ, (eds): The Disunity of Science. Stanford: Stanford University Press; 1996.
6.
go back to reference Oreskes N: Science and public policy: what's proof got to do with it? Environ Sci Policy 2004, 7: 369-383. 10.1016/j.envsci.2004.06.002CrossRef Oreskes N: Science and public policy: what's proof got to do with it? Environ Sci Policy 2004, 7: 369-383. 10.1016/j.envsci.2004.06.002CrossRef
7.
go back to reference Harlow LL, Mulaik SA, Steiger JH: What If There Were No Significance Tests?. Mahaw, NJ: Erlbaum; 1997. Harlow LL, Mulaik SA, Steiger JH: What If There Were No Significance Tests?. Mahaw, NJ: Erlbaum; 1997.
8.
go back to reference Kline RB: Beyond Significance Testing. Washington, DC: American Psychological Association; 2004. Kline RB: Beyond Significance Testing. Washington, DC: American Psychological Association; 2004.
9.
go back to reference Nickerson RS: Null hypothesis significance testing: a review of an old and continuing controversy. Psych Methods 2000, 5: 241-301. 10.1037/1082-989X.5.2.241CrossRef Nickerson RS: Null hypothesis significance testing: a review of an old and continuing controversy. Psych Methods 2000, 5: 241-301. 10.1037/1082-989X.5.2.241CrossRef
10.
go back to reference Mulder RWAW: Impact of transport and related stresses on the incidence and extent of human pathogens in pigmeat and poultry. J Food Safety 1995, 15: 239-246. 10.1111/j.1745-4565.1995.tb00136.xCrossRef Mulder RWAW: Impact of transport and related stresses on the incidence and extent of human pathogens in pigmeat and poultry. J Food Safety 1995, 15: 239-246. 10.1111/j.1745-4565.1995.tb00136.xCrossRef
11.
go back to reference Barta Z, McNamara JM, Houston AI, Weber TP, Hedenström A, Feró O: Optimal moult strategies in migratory birds. Phil Trans R Soc B 2008, 363: 211-229. 10.1098/rstb.2007.2136PubMedCentralCrossRefPubMed Barta Z, McNamara JM, Houston AI, Weber TP, Hedenström A, Feró O: Optimal moult strategies in migratory birds. Phil Trans R Soc B 2008, 363: 211-229. 10.1098/rstb.2007.2136PubMedCentralCrossRefPubMed
12.
go back to reference Berthold P: Control of Bird Migration. London: Chapman & Hall; 1996. Berthold P: Control of Bird Migration. London: Chapman & Hall; 1996.
13.
go back to reference van Gils JA, Munster VJ, Radersma R, Liefhebber D, Fouchier RAM, Klaassen M: Hampered foraging and migratory performance in swans infected with low-pathogenic influenza A virus. PLoS One 2007, 1: e184. 10.1371/journal.pone.0000184CrossRef van Gils JA, Munster VJ, Radersma R, Liefhebber D, Fouchier RAM, Klaassen M: Hampered foraging and migratory performance in swans infected with low-pathogenic influenza A virus. PLoS One 2007, 1: e184. 10.1371/journal.pone.0000184CrossRef
14.
go back to reference Hasselquist D, Lindström Å, Jenni-Eiermann S, Koolhaas A, Piersma T: Long flights do not influence immune responses of a long-distance migrant bird: a wind-tunnel experiment. J Exp Biol 2007, 210: 1123-1131. 10.1242/jeb.02712CrossRefPubMed Hasselquist D, Lindström Å, Jenni-Eiermann S, Koolhaas A, Piersma T: Long flights do not influence immune responses of a long-distance migrant bird: a wind-tunnel experiment. J Exp Biol 2007, 210: 1123-1131. 10.1242/jeb.02712CrossRefPubMed
Metadata
Title
Migratory birds, the H5N1 influenza virus and the scientific method
Authors
Thomas P Weber
Nikolaos I Stilianakis
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2008
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/1743-422X-5-57

Other articles of this Issue 1/2008

Virology Journal 1/2008 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.