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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2021

01-12-2021 | Migraine | Research article

Structural brain network characteristics in patients with episodic and chronic migraine

Authors: Lars Michels, Nabin Koirala, Sergiu Groppa, Roger Luechinger, Andreas R. Gantenbein, Peter S. Sandor, Spyros Kollias, Franz Riederer, Muthuraman Muthuraman

Published in: The Journal of Headache and Pain | Issue 1/2021

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Abstract

Background

Migraine is a primary headache disorder that can be classified into an episodic (EM) and a chronic form (CM). Network analysis within the graph-theoretical framework based on connectivity patterns provides an approach to observe large-scale structural integrity. We test the hypothesis that migraineurs are characterized by a segregated network.

Methods

19 healthy controls (HC), 17 EM patients and 12 CM patients were included. Cortical thickness and subcortical volumes were computed, and topology was analyzed using a graph theory analytical framework and network-based statistics. We further used support vector machines regression (SVR) to identify whether these network measures were able to predict clinical parameters.

Results

Network based statistics revealed significantly lower interregional connectivity strength between anatomical compartments including the fronto-temporal, parietal and visual areas in EM and CM when compared to HC. Higher assortativity was seen in both patients’ group, with higher modularity for CM and higher transitivity for EM compared to HC. For subcortical networks, higher assortativity and transitivity were observed for both patients’ group with higher modularity for CM. SVR revealed that network measures could robustly predict clinical parameters for migraineurs.

Conclusion

We found global network disruption for EM and CM indicated by highly segregated network in migraine patients compared to HC. Higher modularity but lower clustering coefficient in CM is suggestive of more segregation in this group compared to EM. The presence of a segregated network could be a sign of maladaptive reorganization of headache related brain circuits, leading to migraine attacks or secondary alterations to pain.
Appendix
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Metadata
Title
Structural brain network characteristics in patients with episodic and chronic migraine
Authors
Lars Michels
Nabin Koirala
Sergiu Groppa
Roger Luechinger
Andreas R. Gantenbein
Peter S. Sandor
Spyros Kollias
Franz Riederer
Muthuraman Muthuraman
Publication date
01-12-2021
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2021
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-021-01216-8

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