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Published in: Drugs 18/2017

01-12-2017 | Review Article

Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options and Potential Targets for Novel Therapies

Authors: Julie Dyall, Robin Gross, Jason Kindrachuk, Reed F. Johnson, Gene G. Olinger Jr., Lisa E. Hensley, Matthew B. Frieman, Peter B. Jahrling

Published in: Drugs | Issue 18/2017

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Abstract

No specific antivirals are currently available for two emerging infectious diseases, Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS). A literature search was performed covering pathogenesis, clinical features and therapeutics, clinically developed drugs for repurposing and novel drug targets. This review presents current knowledge on the epidemiology, pathogenesis and clinical features of the SARS and MERS coronaviruses. The rationale for and outcomes with treatments used for SARS and MERS is discussed. The main focus of the review is on drug development and the potential that drugs approved for other indications provide for repurposing. The drugs we discuss belong to a wide range of different drug classes, such as cancer therapeutics, antipsychotics, and antimalarials. In addition to their activity against MERS and SARS coronaviruses, many of these approved drugs have broad-spectrum potential and have already been in clinical use for treating other viral infections. A wealth of knowledge is available for these drugs. However, the information in this review is not meant to guide clinical decisions, and any therapeutic described here should only be used in context of a clinical trial. Potential targets for novel antivirals and antibodies are discussed as well as lessons learned from treatment development for other RNA viruses. The article concludes with a discussion of the gaps in our knowledge and areas for future research on emerging coronaviruses.
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Metadata
Title
Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options and Potential Targets for Novel Therapies
Authors
Julie Dyall
Robin Gross
Jason Kindrachuk
Reed F. Johnson
Gene G. Olinger Jr.
Lisa E. Hensley
Matthew B. Frieman
Peter B. Jahrling
Publication date
01-12-2017
Publisher
Springer International Publishing
Published in
Drugs / Issue 18/2017
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI
https://doi.org/10.1007/s40265-017-0830-1

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