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Cancer Cell International
Published in: Cancer Cell International 1/2024

Open Access 01-12-2024 | Metastasis | Review

Unravelling immune microenvironment features underlying tumor progression in the single-cell era

Authors: Qilian Du, Qi An, Jiajun Zhang, Chao Liu, Qinyong Hu

Published in: Cancer Cell International | Issue 1/2024

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Abstract

The relationship between the immune cell and tumor occurrence and progression remains unclear. Profiling alterations in the tumor immune microenvironment (TIME) at high resolution is crucial to identify factors influencing cancer progression and enhance the effectiveness of immunotherapy. However, traditional sequencing methods, including bulk RNA sequencing, exhibit varying degrees of masking the cellular heterogeneity and immunophenotypic changes observed in early and late-stage tumors. Single-cell RNA sequencing (scRNA-seq) has provided significant and precise TIME landscapes. Consequently, this review has highlighted TIME cellular and molecular changes in tumorigenesis and progression elucidated through recent scRNA-seq studies. Specifically, we have summarized the cellular heterogeneity of TIME at different stages, including early, late, and metastatic stages. Moreover, we have outlined the related variations that may promote tumor occurrence and metastasis in the single-cell era. The widespread applications of scRNA-seq in TIME will comprehensively redefine the understanding of tumor biology and furnish more effective immunotherapy strategies.
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Metadata
Title
Unravelling immune microenvironment features underlying tumor progression in the single-cell era
Authors
Qilian Du
Qi An
Jiajun Zhang
Chao Liu
Qinyong Hu
Publication date
01-12-2024
Publisher
BioMed Central
Keyword
Metastasis
Published in
Cancer Cell International / Issue 1/2024
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-024-03335-z

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