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Chinese Medicine
Published in: Chinese Medicine 1/2019

Open Access 01-12-2019 | Metastasis | Review

Traditional Chinese Medicine and regulatory roles on epithelial–mesenchymal transitions

Authors: Jing Bai, Wee Chiew Kwok, Jean-Paul Thiery

Published in: Chinese Medicine | Issue 1/2019

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Abstract

Epithelial–mesenchymal transition (EMT) is a critical biological process allowing epithelial cells to de-differentiate into mesenchymal cells. Orchestrated signaling pathways cooperatively induce EMT and effect physiological, sometimes pathological outcomes. Traditional Chinese Medicine (TCM) has been clinically prescribed for thousands of years and recent studies have found that TCM therapies can participate in EMT regulation. In this review, the historical discovery of EMT will be introduced, followed by a brief overview of its major roles in development and diseases. The second section will focus on EMT in organ fibrosis and tissue regeneration. The third section discusses EMT-induced cancer metastasis, and details how EMT contribute to distant dissemination. Finally, new EMT players are described, namely microRNA, epigenetic modifications, and alternative splicing. TCM drugs that affect EMT proven through an evidence-based research approach will be presented in each section.
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Metadata
Title
Traditional Chinese Medicine and regulatory roles on epithelial–mesenchymal transitions
Authors
Jing Bai
Wee Chiew Kwok
Jean-Paul Thiery
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Metastasis
Published in
Chinese Medicine / Issue 1/2019
Electronic ISSN: 1749-8546
DOI
https://doi.org/10.1186/s13020-019-0257-6

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