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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 13/2021

01-12-2021 | Metastasis | Pediatric Oncology

Value of the Sentinel Node Procedure in Pediatric Extremity Rhabdomyosarcoma: A Systematic Review and Retrospective Cohort Study

Authors: Bernadette Jeremiasse, MSc, MD, Alida F. W. van der Steeg, PhD, MD, Marta Fiocco, PhD, Monique G. G. Hobbelink, PhD, MD, Johannes H. M. Merks, PhD, MD, Jan Godzinski, PhD, MD, Barry L. Shulkin, MSc, MD, Marc H. W. A. Wijnen, MD, Cecilia E. J. Terwisscha van Scheltinga, MSc, MD

Published in: Annals of Surgical Oncology | Issue 13/2021

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Abstract

Background

Our aim is to show whether the sentinel node procedure (SNP) is recommendable for pediatric patients with extremity rhabdomyosarcoma (RMS). Lymph node metastases are an important prognostic factor in pediatric patients with extremity RMS. Accurate nodal staging is necessary to treat the patient accordingly. An alternative to the current recommended lymph node sampling is the sentinel node procedure (SNP).

Methods

A systematic review was performed summarizing all published cases of SNP in addition to 13 cases from our hospital and 8 cases from two other hospitals that have not been published before.

Results

For all patients (n = 55), at least one SLN was identified, but the SNP technique used was not uniform. The SNP changed the nodal classification of eight patients (17.0%) and had a false-negative rate of 10.5%.

Conclusions

The SNP is recommendable for pediatric patients with extremity RMS. It can change lymph node status and can be used to sample patients in a more targeted way than nodal sampling alone. Therefore, we recommend use of the SNP in addition to clinical and radiological nodal assessment for pediatric patients with extremity RMS.
Appendix
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Metadata
Title
Value of the Sentinel Node Procedure in Pediatric Extremity Rhabdomyosarcoma: A Systematic Review and Retrospective Cohort Study
Authors
Bernadette Jeremiasse, MSc, MD
Alida F. W. van der Steeg, PhD, MD
Marta Fiocco, PhD
Monique G. G. Hobbelink, PhD, MD
Johannes H. M. Merks, PhD, MD
Jan Godzinski, PhD, MD
Barry L. Shulkin, MSc, MD
Marc H. W. A. Wijnen, MD
Cecilia E. J. Terwisscha van Scheltinga, MSc, MD
Publication date
01-12-2021
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 13/2021
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-021-10035-9

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