Isolated brachioradialis metastasis of gastric adenocarcinoma after R0 resection

go back to reference SEER Data (Surveillance E, and End Results). Cancer of the stomach. Cancer Statistics Review (1975-2014) (https://seer.cancer.gov/archive/csr/1975_2014/), National Cancer Institute, DCCPS, Surveillance Research Program, updated April 2, 2018. SEER Data (Surveillance E, and End Results). Cancer of the stomach. Cancer Statistics Review (1975-2014) (https://​seer.​cancer.​gov/​archive/​csr/​1975_​2014/​), National Cancer Institute, DCCPS, Surveillance Research Program, updated April 2, 2018.

go back to reference Maconi G, Manes G, Porro GB. Role of symptoms in diagnosis and outcome of gastric cancer. World J Gastroenterol. 2008;14(8):1149–55. https://doi.org/10.3748/wjg.14.1149.CrossRefPubMedPubMedCentral Maconi G, Manes G, Porro GB. Role of symptoms in diagnosis and outcome of gastric cancer. World J Gastroenterol. 2008;14(8):1149–55. https://​doi.​org/​10.​3748/​wjg.​14.​1149.CrossRefPubMedPubMedCentral

go back to reference Riihimaki M, Hemminki A, Sundquist K, Sundquist J, Hemminki K. Metastatic spread in patients with gastric cancer. Oncotarget. 2016;7(32):52307–16. https://doi.org/10.18632/oncotarget.10740.CrossRefPubMedPubMedCentral Riihimaki M, Hemminki A, Sundquist K, Sundquist J, Hemminki K. Metastatic spread in patients with gastric cancer. Oncotarget. 2016;7(32):52307–16. https://​doi.​org/​10.​18632/​oncotarget.​10740.CrossRefPubMedPubMedCentral

go back to reference Hu B, El Hajj N, Sittler S, Lammert N, Barnes R, Meloni-Ehrig A. Gastric cancer: classification, histology and application of molecular pathology. J Gastrointest Oncol. 2012;3(3):251–61. https://doi.org/10.3978/j.issn.2078-6891.2012.021.CrossRefPubMedPubMedCentral Hu B, El Hajj N, Sittler S, Lammert N, Barnes R, Meloni-Ehrig A. Gastric cancer: classification, histology and application of molecular pathology. J Gastrointest Oncol. 2012;3(3):251–61. https://​doi.​org/​10.​3978/​j.​issn.​2078-6891.​2012.​021.CrossRefPubMedPubMedCentral

go back to reference Yang D, Hendifar A, Lenz C, Togawa K, Lenz F, Lurje G, Pohl A, Winder T, Ning Y, Groshen S, Lenz HJ. Survival of metastatic gastric cancer: significance of age, sex and race/ethnicity. J Gastrointest Oncol. 2011;2(2):77–84. https://doi.org/10.3978/j.issn.2078-6891.2010.025.CrossRefPubMedPubMedCentral Yang D, Hendifar A, Lenz C, Togawa K, Lenz F, Lurje G, Pohl A, Winder T, Ning Y, Groshen S, Lenz HJ. Survival of metastatic gastric cancer: significance of age, sex and race/ethnicity. J Gastrointest Oncol. 2011;2(2):77–84. https://​doi.​org/​10.​3978/​j.​issn.​2078-6891.​2010.​025.CrossRefPubMedPubMedCentral

go back to reference Sato N, Sawae Y, Fukamachi K. Case of stomach cancer with remote metastases to the entire body, especially to the spleen and bilateral iliopsoas. Naika Intern Med. 1962;9:774–8. Sato N, Sawae Y, Fukamachi K. Case of stomach cancer with remote metastases to the entire body, especially to the spleen and bilateral iliopsoas. Naika Intern Med. 1962;9:774–8.

go back to reference Treves R, Barruch D, Desproges-Gotteron R. Les metastases musculaires. Sem Hop Paris. 1979;55:1471–5. Treves R, Barruch D, Desproges-Gotteron R. Les metastases musculaires. Sem Hop Paris. 1979;55:1471–5.

go back to reference Obley DL, Slasky BS, Peel RL, Rosenbaum LH, Nicholas JJ, Ellis LD. Bone-forming gastric metastases in muscle—computed tomographic demonstration. J Comput Tomogr. 1983;7(2):129–34. https://doi.org/10.1016/0149-936X(83)90032-2.CrossRefPubMed Obley DL, Slasky BS, Peel RL, Rosenbaum LH, Nicholas JJ, Ellis LD. Bone-forming gastric metastases in muscle—computed tomographic demonstration. J Comput Tomogr. 1983;7(2):129–34. https://​doi.​org/​10.​1016/​0149-936X(83)90032-2.CrossRefPubMed

go back to reference Fujiwara R, Saga T, Akashi N, Takegoshi T, Saitoh K, Tokuda T, Kitoh C, Ichiyanagi K, Doishita K. Heterotopic ossification in the skeletal muscle metastases of advanced stomach cancer. Gan no rinsho Jpn J Cancer Clin. 1983;29(12):1471–5. Fujiwara R, Saga T, Akashi N, Takegoshi T, Saitoh K, Tokuda T, Kitoh C, Ichiyanagi K, Doishita K. Heterotopic ossification in the skeletal muscle metastases of advanced stomach cancer. Gan no rinsho Jpn J Cancer Clin. 1983;29(12):1471–5.

go back to reference Rosenbaum LH, Nicholas JJ, Slasky BS, Obley DL, Ellis LD. Malignant myositis ossificans: occult gastric carcinoma presenting as an acute rheumatic disorder. Ann Rheum Dis. 1984;43(1):95–7. https://doi.org/10.1136/ard.43.1.95.CrossRefPubMedPubMedCentral Rosenbaum LH, Nicholas JJ, Slasky BS, Obley DL, Ellis LD. Malignant myositis ossificans: occult gastric carcinoma presenting as an acute rheumatic disorder. Ann Rheum Dis. 1984;43(1):95–7. https://​doi.​org/​10.​1136/​ard.​43.​1.​95.CrossRefPubMedPubMedCentral

go back to reference Arnold RW, Adams BA, Camoriano JK, Dyer JA. Acquired divergent strabismus: presumed metastatic gastric carcinoma to the medial rectus muscle. J Pediatr Ophthalmol Strabismus. 1989;26(1):50–1.PubMed Arnold RW, Adams BA, Camoriano JK, Dyer JA. Acquired divergent strabismus: presumed metastatic gastric carcinoma to the medial rectus muscle. J Pediatr Ophthalmol Strabismus. 1989;26(1):50–1.PubMed

go back to reference Porile JL, Olopade OI, Hoffman PC. Gastric adenocarcinoma presenting with soft tissue masses. Am J Gastroenterol (Springer Nature). 1990;85(1):76–7. Porile JL, Olopade OI, Hoffman PC. Gastric adenocarcinoma presenting with soft tissue masses. Am J Gastroenterol (Springer Nature). 1990;85(1):76–7.

go back to reference Sudo AK, Ogihara YO, Shiokawa YA, Fujinami SH, Sekiguchi SH. Intramuscular metastasis of carcinoma. Clin Orthop Relat Res. 1993;1(296):213–7. Sudo AK, Ogihara YO, Shiokawa YA, Fujinami SH, Sekiguchi SH. Intramuscular metastasis of carcinoma. Clin Orthop Relat Res. 1993;1(296):213–7.

go back to reference Fred W, Van Gelderen C. Gastric carcinoma metastases to extraocular muscles. J Comput Assist Tomogr. 1993;17(3):499. https://doi.org/10.1097/00004728-199305000-00035.CrossRef Fred W, Van Gelderen C. Gastric carcinoma metastases to extraocular muscles. J Comput Assist Tomogr. 1993;17(3):499. https://​doi.​org/​10.​1097/​00004728-199305000-00035.CrossRef

go back to reference Toillon M, Lepage M, Naudin P, Moreau M, Trutaud-Muresan A, Lamotte A. Muscular metastasis from a gastric adenocarcinoma. Gastroenterol Clin Biol. 1994;18(10):906–7.PubMed Toillon M, Lepage M, Naudin P, Moreau M, Trutaud-Muresan A, Lamotte A. Muscular metastasis from a gastric adenocarcinoma. Gastroenterol Clin Biol. 1994;18(10):906–7.PubMed

go back to reference Amano Y, Kumazaki T. Gastric carcinoma metastasis to calf muscles: MR findings. Radiat Med. 1996;14(1):35–6.PubMed Amano Y, Kumazaki T. Gastric carcinoma metastasis to calf muscles: MR findings. Radiat Med. 1996;14(1):35–6.PubMed

go back to reference Ferri J, Vandenhaute B, Donazzan M. Intra-masseter metastasis of a gastric adenocarcinoma. Rev Stomatol Chir Maxillofac. 1997;98(5):303–5.PubMed Ferri J, Vandenhaute B, Donazzan M. Intra-masseter metastasis of a gastric adenocarcinoma. Rev Stomatol Chir Maxillofac. 1997;98(5):303–5.PubMed

go back to reference Narvaez JA, Narvaez J, Clavaguera MT, Juanola X, Valls C, Fiter J. Bone and skeletal muscle metastases from gastric adenocarcinoma: unusual radiographic, CT and scintigraphic features. Eur Radiol. 1998;8(8):1366–9. https://doi.org/10.1007/s003300050554.CrossRefPubMed Narvaez JA, Narvaez J, Clavaguera MT, Juanola X, Valls C, Fiter J. Bone and skeletal muscle metastases from gastric adenocarcinoma: unusual radiographic, CT and scintigraphic features. Eur Radiol. 1998;8(8):1366–9. https://​doi.​org/​10.​1007/​s003300050554.CrossRefPubMed

go back to reference Pestalozzi BC, Von Hochstetter AR. Muscle metastasis as initial manifestation of adenocarcinoma of the stomach. Schweiz Med Wochenschr. 1998;128(38):1414–7.PubMed Pestalozzi BC, Von Hochstetter AR. Muscle metastasis as initial manifestation of adenocarcinoma of the stomach. Schweiz Med Wochenschr. 1998;128(38):1414–7.PubMed

go back to reference Pinto F, Falleni A, Campoccia S, Lischi DM. Muscular metastasis of a gastric carcinoma: the first sign of a recurrence of the disease. A case. Radiol Med. 1998;95(6):677–8.PubMed Pinto F, Falleni A, Campoccia S, Lischi DM. Muscular metastasis of a gastric carcinoma: the first sign of a recurrence of the disease. A case. Radiol Med. 1998;95(6):677–8.PubMed

go back to reference Oba K, Ito T, Nakatani C, Okamura K, Yamaguchi H, Ajiro Y, Suzuki T, Nakano H, Metori S, Sano K, Hyakusoku H. An elderly patient with gastric carcinoma developing multiple metastasis in skeletal muscle. J Nippon Med Sch. 2001;68(3):271–4. https://doi.org/10.1272/jnms.68.271.CrossRefPubMed Oba K, Ito T, Nakatani C, Okamura K, Yamaguchi H, Ajiro Y, Suzuki T, Nakano H, Metori S, Sano K, Hyakusoku H. An elderly patient with gastric carcinoma developing multiple metastasis in skeletal muscle. J Nippon Med Sch. 2001;68(3):271–4. https://​doi.​org/​10.​1272/​jnms.​68.​271.CrossRefPubMed

go back to reference Kondo S, Onodera H, Kan S, Uchida S, Toguchida J, Imamura M. Intramuscular metastasis from gastric cancer. Gastric Cancer. 2002;5(2):107–11. https://doi.org/10.1007/s101200200018.CrossRefPubMed Kondo S, Onodera H, Kan S, Uchida S, Toguchida J, Imamura M. Intramuscular metastasis from gastric cancer. Gastric Cancer. 2002;5(2):107–11. https://​doi.​org/​10.​1007/​s101200200018.CrossRefPubMed

go back to reference Varma GN, Winston JS, Hill HC, Gibbs JF, Proulx GM. Case 3. Gastric signet ring carcinoma presenting as a diffuse thigh mass. J Clin Oncol. 2003;21(17):3371–3. https://doi.org/10.1200/JCO.2003.09.089.CrossRefPubMed Varma GN, Winston JS, Hill HC, Gibbs JF, Proulx GM. Case 3. Gastric signet ring carcinoma presenting as a diffuse thigh mass. J Clin Oncol. 2003;21(17):3371–3. https://​doi.​org/​10.​1200/​JCO.​2003.​09.​089.CrossRefPubMed

go back to reference Tuoheti Y, Okada K, Osanai T, Nishida J, Ehara S, Hashimoto M, Itoi E. Skeletal muscle metastases of carcinoma: a clinicopathological study of 12 cases. Jpn J Clin Oncol. 2004;34(4):210–4. https://doi.org/10.1093/jjco/hyh036.CrossRefPubMed Tuoheti Y, Okada K, Osanai T, Nishida J, Ehara S, Hashimoto M, Itoi E. Skeletal muscle metastases of carcinoma: a clinicopathological study of 12 cases. Jpn J Clin Oncol. 2004;34(4):210–4. https://​doi.​org/​10.​1093/​jjco/​hyh036.CrossRefPubMed

go back to reference Beşe NŞ, Özgüroĝlu M, Dervişoĝlu S, Kanberoglu K, Öber A. Skeletal muscle: an unusual site of distant metastasis in gastric carcinoma. Radiat Med. 2006;24(2):150–3. https://doi.org/10.1007/BF02493284.CrossRefPubMed Beşe NŞ, Özgüroĝlu M, Dervişoĝlu S, Kanberoglu K, Öber A. Skeletal muscle: an unusual site of distant metastasis in gastric carcinoma. Radiat Med. 2006;24(2):150–3. https://​doi.​org/​10.​1007/​BF02493284.CrossRefPubMed

go back to reference Souayah N, Krivitskaya N, Lee HJ. Lateral rectus muscle metastasis as the initial manifestation of gastric cancer. J Neuroophthalmol. 2008;28(3):240–1. https://doi.org/10.1097/WNO.0b013e318177253a.CrossRefPubMed Souayah N, Krivitskaya N, Lee HJ. Lateral rectus muscle metastasis as the initial manifestation of gastric cancer. J Neuroophthalmol. 2008;28(3):240–1. https://​doi.​org/​10.​1097/​WNO.​0b013e318177253a​.CrossRefPubMed

go back to reference Tougeron D, Hamidou H, Dujardin F, Maillard C, Di Fiore F, Michel P. Unusual skeletal muscle metastasis from gastric adenocarcinoma. Gastroenterol Clin Biol. 2009;33(6-7):485–7. https://doi.org/10.1016/j.gcb.2009.03.018.CrossRefPubMed Tougeron D, Hamidou H, Dujardin F, Maillard C, Di Fiore F, Michel P. Unusual skeletal muscle metastasis from gastric adenocarcinoma. Gastroenterol Clin Biol. 2009;33(6-7):485–7. https://​doi.​org/​10.​1016/​j.​gcb.​2009.​03.​018.CrossRefPubMed

go back to reference Sakuma T, Deguchi R, Takashimizu S, Ogasawara F, Numata M, Ohtani Y, Sato S, Mine T, Iwata Y. Good response chemotherapy for late-recurring gastric cancer in the gluteals, with peritoneal and retroperitoneal dissemination. Tokai J Exp Clin Med. 2011;36(1):8–12.PubMed Sakuma T, Deguchi R, Takashimizu S, Ogasawara F, Numata M, Ohtani Y, Sato S, Mine T, Iwata Y. Good response chemotherapy for late-recurring gastric cancer in the gluteals, with peritoneal and retroperitoneal dissemination. Tokai J Exp Clin Med. 2011;36(1):8–12.PubMed

go back to reference Gogou PV, Polydorou A, Papacharalampous XN, Kondi-Paphiti A, Balafouta MJ, Gennatas CS, Kouvaris JR. Femoral muscle metastasis from gastric carcinoma. Turk J Gastroenterol. 2012;23(5):611–2. https://doi.org/10.4318/tjg.2012.0394.CrossRefPubMed Gogou PV, Polydorou A, Papacharalampous XN, Kondi-Paphiti A, Balafouta MJ, Gennatas CS, Kouvaris JR. Femoral muscle metastasis from gastric carcinoma. Turk J Gastroenterol. 2012;23(5):611–2. https://​doi.​org/​10.​4318/​tjg.​2012.​0394.CrossRefPubMed

go back to reference Pergolini I, Crippa S, Santinelli A, Marmorale C. Skeletal muscle metastases as initial presentation of gastric carcinoma. Am J Case Rep. 2014;15:580.CrossRefPubMedPubMedCentral Pergolini I, Crippa S, Santinelli A, Marmorale C. Skeletal muscle metastases as initial presentation of gastric carcinoma. Am J Case Rep. 2014;15:580.CrossRefPubMedPubMedCentral

go back to reference Lourenço LG, Carlotto JR, Herbella FA, Silva DA, Setti HB. Muscular metastasis from gastric cancer. J Gastrointest Oncol. 2014;5(6):E100.PubMedPubMedCentral Lourenço LG, Carlotto JR, Herbella FA, Silva DA, Setti HB. Muscular metastasis from gastric cancer. J Gastrointest Oncol. 2014;5(6):E100.PubMedPubMedCentral

go back to reference Koga Y, Baba Y, Harada K, Kosumi K, Shigaki H, Kurashige J, Ishimoto T, Iwatsuki M, Miyamoto Y, Sakamoto Y, Yoshida N. Multiple skeletal muscle metastases from poorly differentiated gastric adenocarcinoma. Surg Case Rep. 2015;1(1):1–5.CrossRef Koga Y, Baba Y, Harada K, Kosumi K, Shigaki H, Kurashige J, Ishimoto T, Iwatsuki M, Miyamoto Y, Sakamoto Y, Yoshida N. Multiple skeletal muscle metastases from poorly differentiated gastric adenocarcinoma. Surg Case Rep. 2015;1(1):1–5.CrossRef

go back to reference Wang XX, Liu HQ, Deng FR, Liu J. Skeletal muscle metastases as the first sign of a recurrence of gastric carcinoma. Dig Liver Dis. 2016;48(12):1515. https://doi.org/10.1016/j.dld.2016.09.003.CrossRefPubMed Wang XX, Liu HQ, Deng FR, Liu J. Skeletal muscle metastases as the first sign of a recurrence of gastric carcinoma. Dig Liver Dis. 2016;48(12):1515. https://​doi.​org/​10.​1016/​j.​dld.​2016.​09.​003.CrossRefPubMed

go back to reference Ebisui C, Hamano R, Nushijima Y, Yanagisawa T, Okamura S, Fukuchi N, Murata K, Yokouchi H, Kinuta M, Ohishi K. A case of T1a early gastric cancer that metastasized to the right femoral muscles six years and seven months after radical surgery. Gan to kagaku ryoho Cancer Chemother. 2016;43(12):1893–5. Ebisui C, Hamano R, Nushijima Y, Yanagisawa T, Okamura S, Fukuchi N, Murata K, Yokouchi H, Kinuta M, Ohishi K. A case of T1a early gastric cancer that metastasized to the right femoral muscles six years and seven months after radical surgery. Gan to kagaku ryoho Cancer Chemother. 2016;43(12):1893–5.

go back to reference Temido H, Vilão F, Parente F. Diplopia as rare initial manifestation of gastric cancer. Acta Med Port. 2017;30(4):339.CrossRefPubMed Temido H, Vilão F, Parente F. Diplopia as rare initial manifestation of gastric cancer. Acta Med Port. 2017;30(4):339.CrossRefPubMed

go back to reference Kamitani N, Watanabe A, Kirihataya Y, Ko S. Metachronous skeletal muscle metastasis without any other organ metastases after curative gastrectomy: a case report. Surg Case Rep. 2018;4(1):1–5.CrossRef Kamitani N, Watanabe A, Kirihataya Y, Ko S. Metachronous skeletal muscle metastasis without any other organ metastases after curative gastrectomy: a case report. Surg Case Rep. 2018;4(1):1–5.CrossRef

go back to reference Aguirre LE, Salcedo J, Zuquello R, Garcia-Buitrago M, Ardalan B. Metastatic involvement of skeletal muscle from gastric adenocarcinoma. Oxf Med Case Rep. 2019;2019(8):omz081.CrossRef Aguirre LE, Salcedo J, Zuquello R, Garcia-Buitrago M, Ardalan B. Metastatic involvement of skeletal muscle from gastric adenocarcinoma. Oxf Med Case Rep. 2019;2019(8):omz081.CrossRef

go back to reference Daneti D, Senthamizhselvan K, Verma SK, Mohan P. Gastric adenocarcinoma presenting with multiple skeletal muscle metastases. BMJ Case Rep. 2021;14(1):e239518. https://doi.org/10.1136/bcr-2020-239518.CrossRefPubMed Daneti D, Senthamizhselvan K, Verma SK, Mohan P. Gastric adenocarcinoma presenting with multiple skeletal muscle metastases. BMJ Case Rep. 2021;14(1):e239518. https://​doi.​org/​10.​1136/​bcr-2020-239518.CrossRefPubMed

go back to reference Ajani JAM, D’Amico TA, Bentrem DJ, Chao J, Corvera C, Das P, Denlinger CS, Enzinger PC, Fanta P, Farjah F, Gerdes H, Gibson M, Glasgow RE, Hochwald S, Hofstetter WL, Ilson DH, Johung KL, Keswani RN, Kleinberg LR, Klempner S, Leong S, Ly QP, Matkovskyj KA, McNamara M, Mucahy MF, Paluri RK, Park H, Perry KA, Pimiento J, Poultsides GA, Roses RE, Strong VE, Wiesner G, Willett CG, Yakoub D. National Comprehensive Cancer Network (NCCN) clinical practice guidelines in oncology: gastric cancer; 2020. Ajani JAM, D’Amico TA, Bentrem DJ, Chao J, Corvera C, Das P, Denlinger CS, Enzinger PC, Fanta P, Farjah F, Gerdes H, Gibson M, Glasgow RE, Hochwald S, Hofstetter WL, Ilson DH, Johung KL, Keswani RN, Kleinberg LR, Klempner S, Leong S, Ly QP, Matkovskyj KA, McNamara M, Mucahy MF, Paluri RK, Park H, Perry KA, Pimiento J, Poultsides GA, Roses RE, Strong VE, Wiesner G, Willett CG, Yakoub D. National Comprehensive Cancer Network (NCCN) clinical practice guidelines in oncology: gastric cancer; 2020.

go back to reference Chen YC, Fang WL, Wang RF, Liu CA, Yang MH, Lo SS, Wu CW, Li AFY, Shyr YM, Huang KH. Clinicopathological variation of lauren classification in gastric cancer. Pathol Oncol Res. 2016;22(1):197–202. https://doi.org/10.1007/s12253-015-9996-6.CrossRefPubMed Chen YC, Fang WL, Wang RF, Liu CA, Yang MH, Lo SS, Wu CW, Li AFY, Shyr YM, Huang KH. Clinicopathological variation of lauren classification in gastric cancer. Pathol Oncol Res. 2016;22(1):197–202. https://​doi.​org/​10.​1007/​s12253-015-9996-6.CrossRefPubMed

go back to reference Tan IB, Ivanova T, Lim KH, Ong CW, Deng N, Lee J, et al. Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy. Gastroenterology. 2011;141(2):476–85.e1-11.CrossRefPubMed Tan IB, Ivanova T, Lim KH, Ong CW, Deng N, Lee J, et al. Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy. Gastroenterology. 2011;141(2):476–85.e1-11.CrossRefPubMed

go back to reference Sahasrabudhe R, Lott P, Bohorquez M, Toal T, Estrada AP, Suarez JJ, Brea-Fernández A, Cameselle-Teijeiro J, Pinto C, Ramos I, Mantilla A, Prieto R, Corvalan A, Norero E, Alvarez C, Tapia T, Carvallo P, Gonzalez LM, Cock-Rada A, Solano A, Neffa F, Della Valle A, Yau C, Soares G, Borowsky A, Hu N, He LJ, Han XY, Taylor PR, Goldstein AM, Torres J, Echeverry M, Ruiz-Ponte C, Teixeira MR, Carvajal-Carmona LG, Echeverry M, Bohorquez M, Prieto R, Suarez J, Mateus G, Bravo MM, Bolaños F, Vélez A, Corvalan A, Carvallo P, Torres J, Carvajal-Carmona L. Germline mutations in PALB2, BRCA1, and RAD51C, which regulate DNA recombination repair, in patients with gastric cancer. Gastroenterology. 2017;152(5):983–6.e6. https://doi.org/10.1053/j.gastro.2016.12.010.CrossRefPubMed Sahasrabudhe R, Lott P, Bohorquez M, Toal T, Estrada AP, Suarez JJ, Brea-Fernández A, Cameselle-Teijeiro J, Pinto C, Ramos I, Mantilla A, Prieto R, Corvalan A, Norero E, Alvarez C, Tapia T, Carvallo P, Gonzalez LM, Cock-Rada A, Solano A, Neffa F, Della Valle A, Yau C, Soares G, Borowsky A, Hu N, He LJ, Han XY, Taylor PR, Goldstein AM, Torres J, Echeverry M, Ruiz-Ponte C, Teixeira MR, Carvajal-Carmona LG, Echeverry M, Bohorquez M, Prieto R, Suarez J, Mateus G, Bravo MM, Bolaños F, Vélez A, Corvalan A, Carvallo P, Torres J, Carvajal-Carmona L. Germline mutations in PALB2, BRCA1, and RAD51C, which regulate DNA recombination repair, in patients with gastric cancer. Gastroenterology. 2017;152(5):983–6.e6. https://​doi.​org/​10.​1053/​j.​gastro.​2016.​12.​010.CrossRefPubMed

go back to reference Xiao YP, Wu DY, Xu L, Xin Y. Loss of heterozygosity and microsatellite instabilities of fragile histidine triad gene in gastric carcinoma. World J Gastroenterol. 2006;12(23):3766–9. https://doi.org/10.3748/wjg.v12.i23.3766.CrossRefPubMedPubMedCentral Xiao YP, Wu DY, Xu L, Xin Y. Loss of heterozygosity and microsatellite instabilities of fragile histidine triad gene in gastric carcinoma. World J Gastroenterol. 2006;12(23):3766–9. https://​doi.​org/​10.​3748/​wjg.​v12.​i23.​3766.CrossRefPubMedPubMedCentral

go back to reference Sato K, Tamura G, Tsuchiya T, Endoh Y, Usuba O, Kimura W, Motoyama T. Frequent loss of expression without sequence mutations of the DCC gene in primary gastric cancer. Br J Cancer. 2001;85(2):199–203. https://doi.org/10.1054/bjoc.2001.1888.CrossRefPubMedPubMedCentral Sato K, Tamura G, Tsuchiya T, Endoh Y, Usuba O, Kimura W, Motoyama T. Frequent loss of expression without sequence mutations of the DCC gene in primary gastric cancer. Br J Cancer. 2001;85(2):199–203. https://​doi.​org/​10.​1054/​bjoc.​2001.​1888.CrossRefPubMedPubMedCentral

go back to reference Yasui W, Sentani K, Motoshita J, Nakayama H. Molecular pathobiology of gastric cancer. Scand J Surg. 2006;95(4):225–31. https://doi.org/10.1177/145749690609500403.CrossRefPubMed Yasui W, Sentani K, Motoshita J, Nakayama H. Molecular pathobiology of gastric cancer. Scand J Surg. 2006;95(4):225–31. https://​doi.​org/​10.​1177/​1457496906095004​03.CrossRefPubMed

go back to reference Yokozaki H, Shitara Y, Fujimoto J, Hiyama T, Yasui W, Tahara E. Alterations of p73 preferentially occur in gastric adenocarcinomas with foveolar epithelial phenotype. Int J Cancer. 1999;83(2):192–6. https://doi.org/10.1002/(SICI)1097-0215(19991008)83:2<192::AID-IJC8>3.0.CO;2-E.CrossRefPubMed Yokozaki H, Shitara Y, Fujimoto J, Hiyama T, Yasui W, Tahara E. Alterations of p73 preferentially occur in gastric adenocarcinomas with foveolar epithelial phenotype. Int J Cancer. 1999;83(2):192–6. https://​doi.​org/​10.​1002/​(SICI)1097-0215(19991008)83:​2<192:​:​AID-IJC8>3.​0.​CO;2-E.CrossRefPubMed

go back to reference Morgan C, Jenkins GJ, Ashton T, Griffiths AP, Baxter JN, Parry EM, et al. Detection of p53 mutations in precancerous gastric tissue. Br J Cancer. 2003;89(7):1314–9. https://doi.org/10.1038/sj.bjc.6601302.CrossRefPubMedPubMedCentral Morgan C, Jenkins GJ, Ashton T, Griffiths AP, Baxter JN, Parry EM, et al. Detection of p53 mutations in precancerous gastric tissue. Br J Cancer. 2003;89(7):1314–9. https://​doi.​org/​10.​1038/​sj.​bjc.​6601302.CrossRefPubMedPubMedCentral

go back to reference Shiao YH, Rugge M, Correa P, Lehmann HP, Scheer WD. p53 alteration in gastric precancerous lesions. Am J Pathol. 1994;144(3):511–7.PubMedPubMedCentral Shiao YH, Rugge M, Correa P, Lehmann HP, Scheer WD. p53 alteration in gastric precancerous lesions. Am J Pathol. 1994;144(3):511–7.PubMedPubMedCentral

go back to reference Tomkova K, Belkhiri A, El-Rifai W, Zaika AI. p73 isoforms can induce T-cell factor-dependent transcription in gastrointestinal cells. Cancer Res. 2004;64(18):6390–3. https://doi.org/10.1158/0008-5472.CAN-04-2176.CrossRefPubMed Tomkova K, Belkhiri A, El-Rifai W, Zaika AI. p73 isoforms can induce T-cell factor-dependent transcription in gastrointestinal cells. Cancer Res. 2004;64(18):6390–3. https://​doi.​org/​10.​1158/​0008-5472.​CAN-04-2176.CrossRefPubMed

go back to reference Liu X, Liu J, Qiu H, Kong P, Chen S, Li W, Zhan Y, Li Y, Chen Y, Zhou Z, Xu D, Sun X. Prognostic significance of Epstein-Barr virus infection in gastric cancer: a meta-analysis. BMC Cancer. 2015;15(1):782. https://doi.org/10.1186/s12885-015-1813-9.CrossRefPubMedPubMedCentral Liu X, Liu J, Qiu H, Kong P, Chen S, Li W, Zhan Y, Li Y, Chen Y, Zhou Z, Xu D, Sun X. Prognostic significance of Epstein-Barr virus infection in gastric cancer: a meta-analysis. BMC Cancer. 2015;15(1):782. https://​doi.​org/​10.​1186/​s12885-015-1813-9.CrossRefPubMedPubMedCentral

go back to reference Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006;355(1):11–20. https://doi.org/10.1056/NEJMoa055531.CrossRefPubMed Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006;355(1):11–20. https://​doi.​org/​10.​1056/​NEJMoa055531.CrossRefPubMed

go back to reference Al-Batran SE, Homann N, Pauligk C, Goetze TO, Meiler J, Kasper S, et al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet. 2019;393(10184):1948–57. https://doi.org/10.1016/S0140-6736(18)32557-1.CrossRefPubMed Al-Batran SE, Homann N, Pauligk C, Goetze TO, Meiler J, Kasper S, et al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet. 2019;393(10184):1948–57. https://​doi.​org/​10.​1016/​S0140-6736(18)32557-1.CrossRefPubMed

go back to reference Fuchs CS, Doi T, Jang RW, Muro K, Satoh T, Machado M, Sun W, Jalal SI, Shah MA, Metges JP, Garrido M, Golan T, Mandala M, Wainberg ZA, Catenacci DV, Ohtsu A, Shitara K, Geva R, Bleeker J, Ko AH, Ku G, Philip P, Enzinger PC, Bang YJ, Levitan D, Wang J, Rosales M, Dalal RP, Yoon HH. Safety and efficacy of pembrolizumab monotherapy in patients with previously treated advanced gastric and gastroesophageal junction cancer: phase 2 clinical KEYNOTE-059 trial. JAMA Oncol. 2018;4(5):e180013. https://doi.org/10.1001/jamaoncol.2018.0013.CrossRefPubMedPubMedCentral Fuchs CS, Doi T, Jang RW, Muro K, Satoh T, Machado M, Sun W, Jalal SI, Shah MA, Metges JP, Garrido M, Golan T, Mandala M, Wainberg ZA, Catenacci DV, Ohtsu A, Shitara K, Geva R, Bleeker J, Ko AH, Ku G, Philip P, Enzinger PC, Bang YJ, Levitan D, Wang J, Rosales M, Dalal RP, Yoon HH. Safety and efficacy of pembrolizumab monotherapy in patients with previously treated advanced gastric and gastroesophageal junction cancer: phase 2 clinical KEYNOTE-059 trial. JAMA Oncol. 2018;4(5):e180013. https://​doi.​org/​10.​1001/​jamaoncol.​2018.​0013.CrossRefPubMedPubMedCentral

go back to reference Brar G, Shah MA. The role of pembrolizumab in the treatment of PD-L1 expressing gastric and gastroesophageal junction adenocarcinoma. Therap Adv Gastroenterol. 2019;12:1756284819869767.CrossRefPubMedPubMedCentral Brar G, Shah MA. The role of pembrolizumab in the treatment of PD-L1 expressing gastric and gastroesophageal junction adenocarcinoma. Therap Adv Gastroenterol. 2019;12:1756284819869767.CrossRefPubMedPubMedCentral

go back to reference Apicella M, Corso S, Giordano S. Targeted therapies for gastric cancer: failures and hopes from clinical trials. Oncotarget. 2017;8(34):57654–69. https://doi.org/10.18632/oncotarget.14825.CrossRefPubMedPubMedCentral Apicella M, Corso S, Giordano S. Targeted therapies for gastric cancer: failures and hopes from clinical trials. Oncotarget. 2017;8(34):57654–69. https://​doi.​org/​10.​18632/​oncotarget.​14825.CrossRefPubMedPubMedCentral

go back to reference Coburn N, Cosby R, Klein L, Knight G, Malthaner R, Mamazza J, Mercer CD, Ringash J. Staging and surgical approaches in gastric cancer: a clinical practice guideline. Curr Oncol. 2017;24(5):324–31. https://doi.org/10.3747/co.24.3736.CrossRefPubMedPubMedCentral Coburn N, Cosby R, Klein L, Knight G, Malthaner R, Mamazza J, Mercer CD, Ringash J. Staging and surgical approaches in gastric cancer: a clinical practice guideline. Curr Oncol. 2017;24(5):324–31. https://​doi.​org/​10.​3747/​co.​24.​3736.CrossRefPubMedPubMedCentral

go back to reference De Andrade JP, Mezhir JJ. The critical role of peritoneal cytology in the staging of gastric cancer: an evidence-based review. J Surg Oncol. 2014;110(3):291–7. https://doi.org/10.1002/jso.23632.CrossRefPubMed De Andrade JP, Mezhir JJ. The critical role of peritoneal cytology in the staging of gastric cancer: an evidence-based review. J Surg Oncol. 2014;110(3):291–7. https://​doi.​org/​10.​1002/​jso.​23632.CrossRefPubMed

go back to reference Mezhir JJ, Shah MA, Jacks LM, Brennan MF, Coit DG, Strong VE. Positive peritoneal cytology in patients with gastric cancer: natural history and outcome of 291 patients. Indian J Surg Oncol. 2011;2(1):16–23. https://doi.org/10.1007/s13193-011-0074-6.CrossRefPubMedPubMedCentral Mezhir JJ, Shah MA, Jacks LM, Brennan MF, Coit DG, Strong VE. Positive peritoneal cytology in patients with gastric cancer: natural history and outcome of 291 patients. Indian J Surg Oncol. 2011;2(1):16–23. https://​doi.​org/​10.​1007/​s13193-011-0074-6.CrossRefPubMedPubMedCentral

go back to reference Yasufuku I, Nunobe S, Ida S, Kumagai K, Ohashi M, Hiki N, Sano T. Conversion therapy for peritoneal lavage cytology-positive type 4 and large type 3 gastric cancer patients selected as candidates for R0 resection by diagnostic staging laparoscopy. Gastric Cancer. 2020;23(2):319–27. https://doi.org/10.1007/s10120-019-00994-0.CrossRefPubMed Yasufuku I, Nunobe S, Ida S, Kumagai K, Ohashi M, Hiki N, Sano T. Conversion therapy for peritoneal lavage cytology-positive type 4 and large type 3 gastric cancer patients selected as candidates for R0 resection by diagnostic staging laparoscopy. Gastric Cancer. 2020;23(2):319–27. https://​doi.​org/​10.​1007/​s10120-019-00994-0.CrossRefPubMed

go back to reference Schmidt B, Yoon SS. D1 versus D2 lymphadenectomy for gastric cancer. J Surg Oncol. 2013;107(3):259–64. https://doi.org/10.1002/jso.23127.CrossRefPubMed Schmidt B, Yoon SS. D1 versus D2 lymphadenectomy for gastric cancer. J Surg Oncol. 2013;107(3):259–64. https://​doi.​org/​10.​1002/​jso.​23127.CrossRefPubMed

go back to reference Songun I, Putter H, Kranenbarg EM, Sasako M, van de Velde CJ. Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial. Lancet Oncol. 2010;11(5):439–49. https://doi.org/10.1016/S1470-2045(10)70070-X.CrossRefPubMed Songun I, Putter H, Kranenbarg EM, Sasako M, van de Velde CJ. Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial. Lancet Oncol. 2010;11(5):439–49. https://​doi.​org/​10.​1016/​S1470-2045(10)70070-X.CrossRefPubMed

go back to reference Douridas GN, Pierrakakis SK. Is there any role for D3 lymphadenectomy in gastric cancer? Front Surg. 2018;5:27. https://doi.org/10.3389/fsurg.2018.00027.CrossRefPubMedPubMedCentral Douridas GN, Pierrakakis SK. Is there any role for D3 lymphadenectomy in gastric cancer? Front Surg. 2018;5:27. https://​doi.​org/​10.​3389/​fsurg.​2018.​00027.CrossRefPubMedPubMedCentral

go back to reference Samples JE, Stitzenberg KB, Meyers MO. Lymph node yield and survival in gastric carcinoma. JCO. 2014;32(15_suppl):4012.CrossRef Samples JE, Stitzenberg KB, Meyers MO. Lymph node yield and survival in gastric carcinoma. JCO. 2014;32(15_suppl):4012.CrossRef

go back to reference Liang Y, Ding X, Wang X, Wang B, Deng J, Zhang L, Liang H. Prognostic value of surgical margin status in gastric cancer patients. ANZ J Surg. 2015;85(9):678–84. https://doi.org/10.1111/ans.12515.CrossRefPubMed Liang Y, Ding X, Wang X, Wang B, Deng J, Zhang L, Liang H. Prognostic value of surgical margin status in gastric cancer patients. ANZ J Surg. 2015;85(9):678–84. https://​doi.​org/​10.​1111/​ans.​12515.CrossRefPubMed

go back to reference Morgagni P, Garcea D, Marrelli D, De Manzoni G, Natalini G, Kurihara H, et al. Resection line involvement after gastric cancer surgery: clinical outcome in nonsurgically retreated patients. World J Surg. 2008;32(12):2661–7. https://doi.org/10.1007/s00268-008-9747-x.CrossRefPubMed Morgagni P, Garcea D, Marrelli D, De Manzoni G, Natalini G, Kurihara H, et al. Resection line involvement after gastric cancer surgery: clinical outcome in nonsurgically retreated patients. World J Surg. 2008;32(12):2661–7. https://​doi.​org/​10.​1007/​s00268-008-9747-x.CrossRefPubMed

go back to reference Kattan MW, Karpeh MS, Mazumdar M, Brennan MF. Postoperative nomogram for disease-specific survival after an R0 resection for gastric carcinoma. J Clin Oncol. 2003;21(19):3647–50. https://doi.org/10.1200/JCO.2003.01.240.CrossRefPubMed Kattan MW, Karpeh MS, Mazumdar M, Brennan MF. Postoperative nomogram for disease-specific survival after an R0 resection for gastric carcinoma. J Clin Oncol. 2003;21(19):3647–50. https://​doi.​org/​10.​1200/​JCO.​2003.​01.​240.CrossRefPubMed

go back to reference Miyazaki M, Itoh H, Nakagawa K, Ambiru S, Shimizu H, Togawa A, Shiobara M, Ohtsuka M, Sasada K, Shimizu Y, Yoshioka S, Nakajima N, Suwa T, Kimura F. Hepatic resection of liver metastases from gastric carcinoma. Am J Gastroenterol. 1997;92(3):490–3. Miyazaki M, Itoh H, Nakagawa K, Ambiru S, Shimizu H, Togawa A, Shiobara M, Ohtsuka M, Sasada K, Shimizu Y, Yoshioka S, Nakajima N, Suwa T, Kimura F. Hepatic resection of liver metastases from gastric carcinoma. Am J Gastroenterol. 1997;92(3):490–3.

go back to reference Young JJ, Pahwa A, Patel M, Jude CM, Nguyen M, Deshmukh M, Huang L, Mohammad SF. Ligaments and lymphatic pathways in gastric adenocarcinoma. Radiographics. 2019;39(3):668–89. https://doi.org/10.1148/rg.2019180113. Young JJ, Pahwa A, Patel M, Jude CM, Nguyen M, Deshmukh M, Huang L, Mohammad SF. Ligaments and lymphatic pathways in gastric adenocarcinoma. Radiographics. 2019;39(3):668–89. https://​doi.​org/​10.​1148/​rg.​2019180113.