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Breast Cancer
Published in: Breast Cancer 1/2018

01-01-2018 | Review Article

CircRNA: a novel type of biomarker for cancer

Authors: He-da Zhang, Lin-hong Jiang, Da-wei Sun, Jun-chen Hou, Zhen-ling Ji

Published in: Breast Cancer | Issue 1/2018

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Abstract

Circular RNAs (circRNAs) are a class of long, non-coding RNAs molecules that shape a covalently closed continuous loop which have no 5′–3′ polarity and contain no polyA tail. CircRNAs also possess relatively jarless framework and are highly tissue-specific expressed in the eukaryotic transcriptome. Emerging evidences have discovered that thousands of endogenous circRNAs are present in mammalian cells and they mediate gene expression at the transcriptional or post-transcriptional level by binding to microRNAs or other molecules and then inhibit their function. Similarly, increasing evidence indicates that circRNAs may play a role in the development of several types of diseases, including atherosclerotic vascular disease risk, neurological disorders, prion diseases, osteoarthritis and diabetes. Furthermore, circRNAs exhibit aberrant expression in multiform types of cancer, including colorectal cancer, hepatocellular carcinoma and pancreatic ductal adenocarcinoma. And based on the function of circRNAs in cancer, we believe that circRNAs may serve as diagnostic or tumor promising biomarkers. Moreover, it will provide a new therapeutic target for the treatment of cancer.
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Metadata
Title
CircRNA: a novel type of biomarker for cancer
Authors
He-da Zhang
Lin-hong Jiang
Da-wei Sun
Jun-chen Hou
Zhen-ling Ji
Publication date
01-01-2018
Publisher
Springer Japan
Published in
Breast Cancer / Issue 1/2018
Print ISSN: 1340-6868
Electronic ISSN: 1880-4233
DOI
https://doi.org/10.1007/s12282-017-0793-9

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