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18-03-2024 | Metastasis | REVIEW

Deciphering cellular and molecular mechanism of MUC13 mucin involved in cancer cell plasticity and drug resistance

Authors: Shabnam Malik, Mohammed Sikander, Mohd Wahid, Anupam Dhasmana, Maryam Sarwat, Sheema Khan, Everardo Cobos, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

Published in: Cancer and Metastasis Reviews

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Abstract

There has been a surge of interest in recent years in understanding the intricate mechanisms underlying cancer progression and treatment resistance. One molecule that has recently emerged in these mechanisms is MUC13 mucin, a transmembrane glycoprotein. Researchers have begun to unravel the molecular complexity of MUC13 and its impact on cancer biology. Studies have shown that MUC13 overexpression can disrupt normal cellular polarity, leading to the acquisition of malignant traits. Furthermore, MUC13 has been associated with increased cancer plasticity, allowing cells to undergo epithelial-mesenchymal transition (EMT) and metastasize. Notably, MUC13 has also been implicated in the development of chemoresistance, rendering cancer cells less responsive to traditional treatment options. Understanding the precise role of MUC13 in cellular plasticity, and chemoresistance could pave the way for the development of targeted therapies to combat cancer progression and enhance treatment efficacy.
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Metadata
Title
Deciphering cellular and molecular mechanism of MUC13 mucin involved in cancer cell plasticity and drug resistance
Authors
Shabnam Malik
Mohammed Sikander
Mohd Wahid
Anupam Dhasmana
Maryam Sarwat
Sheema Khan
Everardo Cobos
Murali M. Yallapu
Meena Jaggi
Subhash C. Chauhan
Publication date
18-03-2024
Publisher
Springer US
Keyword
Metastasis
Published in
Cancer and Metastasis Reviews
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-024-10177-8
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Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

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Prof. Fabrice Barlesi
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