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Published in: Italian Journal of Pediatrics 1/2019

Open Access 01-12-2019 | Meningococcus | Research

Pediatric meningococcocal meningitis in the acute phase: how much does it cost?

Authors: Elena Bozzola, Stefano Guolo, Enea Bonci, Chiara Rossetti, Mauro Bozzola, Massimiliano Raponi, Alberto Villani

Published in: Italian Journal of Pediatrics | Issue 1/2019

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Abstract

Background

Meningococcal meningitis (MM) is known to be responsible of high cost for the Public Health Administration. Aim of the work is to calculate the costs for the hospitalization of pediatric patients affected by MM.

Methods

We calculate the costs for the hospitalization of pediatric patients affected by MM in the acute phase (HAP) over a nine year period. We performed a MEDLINE search to verify the cost of MM HAP reported in other studies.

Results

At Bambino Gesù Children Hospital, the median cost of HAP was of 12,604 euro (range from 9203 to 35,050 euro). Comparing our data with the previous studies, we find out similar results of approximately 16,750 euro (range 12,000–20,000 euro).

Discussion

Despite the relative rarety of the disease, MM is associated to direct high cost of HAP.

Conclusions

Hospital costs are an important end-point in health economic evaluation of the disease and may be useful to policy makers and health economists to understand the potential benefit of improving meningococcal vaccination programmes.
Literature
1.
go back to reference Harrison LH, Mohan N, Kirkpatrick P. Meningococcal group A, C, Y and W-135 conjugate vaccine. Nat Rev Drug Discov. 2010;9(6):429–30.CrossRef Harrison LH, Mohan N, Kirkpatrick P. Meningococcal group A, C, Y and W-135 conjugate vaccine. Nat Rev Drug Discov. 2010;9(6):429–30.CrossRef
2.
go back to reference Viner RM, Booy R, Johnson H, Edmunds WJ, Hudson L, Bedford H, Kaczmarski E, Rajput K, Ramsay M, Christie D. Outcomes of invasive meningococcal serogroup B disease in children and adolescents (MOSAIC): a case-control study. Lancet Neurol. 2012;11(9):774–83.CrossRef Viner RM, Booy R, Johnson H, Edmunds WJ, Hudson L, Bedford H, Kaczmarski E, Rajput K, Ramsay M, Christie D. Outcomes of invasive meningococcal serogroup B disease in children and adolescents (MOSAIC): a case-control study. Lancet Neurol. 2012;11(9):774–83.CrossRef
3.
go back to reference Gianchecchi E, Torelli A, Piccini G, Piccirella S, Montomoli E. Neisseria meningitidis infection: who, when and where? Expert Rev Anti-Infect Ther. 2015;13(10):1249–63.CrossRef Gianchecchi E, Torelli A, Piccini G, Piccirella S, Montomoli E. Neisseria meningitidis infection: who, when and where? Expert Rev Anti-Infect Ther. 2015;13(10):1249–63.CrossRef
5.
go back to reference Darbà J, Kaskens L, Hark M, Wright C. Costs of surviving meningococcal disease in Spain: evaluation for two cases of severe meningitis and septicaemia. Vaccine. 2014 Sep 3;32(39):5006–12.CrossRef Darbà J, Kaskens L, Hark M, Wright C. Costs of surviving meningococcal disease in Spain: evaluation for two cases of severe meningitis and septicaemia. Vaccine. 2014 Sep 3;32(39):5006–12.CrossRef
6.
go back to reference O'Brien JA, Caro JJ, Getsios D. Managing meningococcal disease in the United States: Hospital case characteristics and costs by age. Value Health. 2006 Jul-Aug;9(4):236–43.CrossRef O'Brien JA, Caro JJ, Getsios D. Managing meningococcal disease in the United States: Hospital case characteristics and costs by age. Value Health. 2006 Jul-Aug;9(4):236–43.CrossRef
7.
go back to reference Wang B, Haji Ali Afzali H, Marshall H. The inpatient costs and hospital service use associated with invasive meningococcal disease in South Australian children. Vaccine. 2014;32(37):4791–8.CrossRef Wang B, Haji Ali Afzali H, Marshall H. The inpatient costs and hospital service use associated with invasive meningococcal disease in South Australian children. Vaccine. 2014;32(37):4791–8.CrossRef
8.
go back to reference Sadarangani M, Pollard AJ. Can we control all-cause meningococcal disease in Europe? Clin Microbiol Infect. 2016 pii: S1198-743X(16)30021–0. Sadarangani M, Pollard AJ. Can we control all-cause meningococcal disease in Europe? Clin Microbiol Infect. 2016 pii: S1198-743X(16)30021–0.
9.
go back to reference de Waure C, Miglietta A, Nedovic D, Mereu G, Ricciardi W. Reduction in Neisseria meningitidis infection in Italy after Meningococcal C conjugate vaccine introduction: A time trend analysis of 1994-2012 series. Hum Vaccin Immunother 2016;12(2):467–473. de Waure C, Miglietta A, Nedovic D, Mereu G, Ricciardi W. Reduction in Neisseria meningitidis infection in Italy after Meningococcal C conjugate vaccine introduction: A time trend analysis of 1994-2012 series. Hum Vaccin Immunother 2016;12(2):467–473.
10.
go back to reference Stefanelli P, Fazio C, Neri A, Boros S, Renna G, Pompa MG. National Surveillance System Collaborative Centers. Changing epidemiology of Infant Meningococcal Disease after the introduction of meningococcal serogroup C vaccine in Italy, 2006-2014. Vaccine. 2015;33(31):3678–81.CrossRef Stefanelli P, Fazio C, Neri A, Boros S, Renna G, Pompa MG. National Surveillance System Collaborative Centers. Changing epidemiology of Infant Meningococcal Disease after the introduction of meningococcal serogroup C vaccine in Italy, 2006-2014. Vaccine. 2015;33(31):3678–81.CrossRef
11.
go back to reference Davis KL, Misurski D, Miller J, Karve S. Cost impact of complications in meningococcal disease: evidence from a United States managed care population. Hum Vaccin. 2011 Apr;7(4):458–65.CrossRef Davis KL, Misurski D, Miller J, Karve S. Cost impact of complications in meningococcal disease: evidence from a United States managed care population. Hum Vaccin. 2011 Apr;7(4):458–65.CrossRef
12.
go back to reference Davis KL, Bell TJ, Miller JM, Misurski DA, Bapat B. Hospital costs, length of stay and mortality associated with childhood, adolescent and young adult meningococcal disease in the US. Appl Health Econ Health Policy. 2011;9(3):197–207.CrossRef Davis KL, Bell TJ, Miller JM, Misurski DA, Bapat B. Hospital costs, length of stay and mortality associated with childhood, adolescent and young adult meningococcal disease in the US. Appl Health Econ Health Policy. 2011;9(3):197–207.CrossRef
Metadata
Title
Pediatric meningococcocal meningitis in the acute phase: how much does it cost?
Authors
Elena Bozzola
Stefano Guolo
Enea Bonci
Chiara Rossetti
Mauro Bozzola
Massimiliano Raponi
Alberto Villani
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2019
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-019-0616-z

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