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European Journal of Nutrition
Published in: European Journal of Nutrition 8/2019

01-12-2019 | Original Contribution

Maternal selenium status is profoundly involved in metabolic fetal programming by modulating insulin resistance, oxidative balance and energy homeostasis

Authors: María Luisa Ojeda, Fátima Nogales, Alba Membrilla, Olimpia Carreras

Published in: European Journal of Nutrition | Issue 8/2019

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Abstract

Purpose

High and low levels of selenium (Se) have been related to metabolic disorders in dams and in their offspring. Their relationship to oxidative balance and to AMP-activated protein kinase (AMPK) is some of the mechanisms proposed. The aim of this study is to acquire information about how Se is involved in metabolic programming.

Methods

Three experimental groups of dam rats were used: control (Se: 0.1 ppm), Se supplemented (Se: 0.5 ppm) and Se deficient (Se: 0.01 ppm). At the end of lactation, the pups’ metabolic profile, oxidative balance, Se levels, selenoproteins and IRS-1 hepatic expression, as well as hepatic AMPK activation were measured.

Results

The experimental groups present deep changes in Se homeostasis, selenoproteins and IRS-1 hepatic expression, oxidative balance, AMPK activation ratio and insulin levels. They do, however, have different metabolic profiles.

Conclusions

High- and low-Se diets are linked to insulin resistance, yet the mechanisms involved are completely opposite.

Graphical abstract

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Metadata
Title
Maternal selenium status is profoundly involved in metabolic fetal programming by modulating insulin resistance, oxidative balance and energy homeostasis
Authors
María Luisa Ojeda
Fátima Nogales
Alba Membrilla
Olimpia Carreras
Publication date
01-12-2019
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nutrition / Issue 8/2019
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-018-1861-4

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