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European Journal of Nutrition

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01-12-2019 | Original Contribution

Association between dietary cadmium intake and early gastric cancer risk in a Korean population: a case–control study

Authors: Hyejin Kim, Jeonghee Lee, Hae Dong Woo, Dong Woo Kim, Il Ju Choi, Young-Il Kim, Jeongseon Kim

Published in: European Journal of Nutrition | Issue 8/2019

Abstract

Purpose

Foods such as grains and vegetables are the dominant sources of exposure to cadmium, which has been classified as a carcinogen by various public health agencies. Cadmium exposure is a growing concern due to its associations with numerous harmful health effects, including gastric cancer risk. The objective of this study was to investigate the association of dietary cadmium intake and the consumption of cadmium-contributing foods with early gastric cancer risk.

Methods

A case–control study including 1245 subjects (cases, 415; controls, 830) was conducted in Korea. The dietary cadmium intake and the consumption of cadmium-contributing foods were assessed using a semi-quantitative food frequency questionnaire.

Results

After adjustment for covariates, the gastric cancer risk was increased for participants in the highest tertile of cadmium intake [odds ratios (ORs) 1.33, 95% confidence intervals (95% CIs) 0.94–1.88], but there was no significance. Both female (ORs 2.71, 95% CIs 1.37–5.36) and male (ORs 1.63, 95% CIs 1.07–2.50) participants in the highest tertile of rice consumption had a higher gastric cancer risk than did those in the lowest tertile. Men in the highest tertile of crab consumption had a gastric cancer risk 2.23 times greater than that of men in the lowest tertile (ORs 2.23, 95% CIs 1.21–4.13), but a difference was not seen in women.

Conclusions

Future studies examining the causal effects of dietary cadmium intake and the consumption of cadmium-contributing foods on early gastric cancer risk in large-scale prospective cohorts are recommended.

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Title: Association between dietary cadmium intake and early gastric cancer risk in a Korean population: a case–control study
Authors: Hyejin Kim
Jeonghee Lee
Hae Dong Woo
Dong Woo Kim
Il Ju Choi
Young-Il Kim
Jeongseon Kim
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 8/2019
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-018-1868-x

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