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Diabetologia
Published in: Diabetologia 4/2016

01-04-2016 | Article

Maternal high-fat feeding leads to alterations of brain glucose metabolism in the offspring: positron emission tomography study in a porcine model

Authors: Elena Sanguinetti, Tiziana Liistro, Marco Mainardi, Silvia Pardini, Piero A. Salvadori, Alessandro Vannucci, Silvia Burchielli, Patricia Iozzo

Published in: Diabetologia | Issue 4/2016

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Abstract

Aims/hypothesis

Maternal obesity negatively affects fetal development. Abnormalities in brain glucose metabolism are predictive of metabolic–cognitive disorders.

Methods

We studied the offspring (aged 0, 1, 6, 12 months) of minipigs fed a normal vs high-fat diet (HFD), by positron emission tomography (PET) to measure brain glucose metabolism, and ex vivo assessments of brain insulin receptors (IRβ) and GLUT4.

Results

At birth, brain glucose metabolism and IRβ were twice as high in the offspring of HFD-fed than control mothers. During infancy and youth, brain glucose uptake, GLUT4 and IRβ increased in the offspring of control mothers and decreased in those of HFD-fed mothers, leading to a 40–85% difference (p < 0.05), and severe glycogen depletion, lasting until adulthood.

Conclusions/interpretation

Maternal high-fat feeding leads to brain glucose overexposure during fetal development, followed by long-lasting depression in brain glucose metabolism in minipigs. These features may predispose the offspring to develop metabolic–neurodegenerative diseases.
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Metadata
Title
Maternal high-fat feeding leads to alterations of brain glucose metabolism in the offspring: positron emission tomography study in a porcine model
Authors
Elena Sanguinetti
Tiziana Liistro
Marco Mainardi
Silvia Pardini
Piero A. Salvadori
Alessandro Vannucci
Silvia Burchielli
Patricia Iozzo
Publication date
01-04-2016
Publisher
Springer Berlin Heidelberg
Published in
Diabetologia / Issue 4/2016
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-015-3848-5

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