Skip to main content
Top
Published in: European Journal of Nuclear Medicine and Molecular Imaging 12/2009

01-12-2009 | Guidelines

EANM procedure guidelines for PET brain imaging using [18F]FDG, version 2

Authors: Andrea Varrone, Susanne Asenbaum, Thierry Vander Borght, Jan Booij, Flavio Nobili, Kjell Någren, Jacques Darcourt, Özlem L. Kapucu, Klaus Tatsch, Peter Bartenstein, Koen Van Laere

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 12/2009

Login to get access

Abstract

These guidelines summarize the current views of the European Association of Nuclear Medicine Neuroimaging Committee (ENC). The purpose of the guidelines is to assist nuclear medicine practitioners in making recommendations, performing, interpreting, and reporting the results of fluorine-18 fluoro-2-deoxyglucose ([18F]FDG) PET imaging of the brain. The aim is to help achieve a high standard of FDG imaging, which will increase the diagnostic impact of this technique in neurological and psychiatric practice. The present document replaces a former version of the guidelines that were published in 2002 [1] and includes an update in the light of advances in PET technology, the introduction of hybrid PET/CT systems and the broadening clinical indications for FDG brain imaging. These guidelines are intended to present information specifically adapted for European practice. The information provided should be taken in the context of local conditions and regulations.
Literature
1.
go back to reference Bartenstein P, Asenbaum S, Catafau A, et al. European Association of Nuclear Medicine procedure guidelines for brain imaging using [(18)F]FDG. Eur J Nucl Med Mol Imaging 2002;29:BP43–8.PubMed Bartenstein P, Asenbaum S, Catafau A, et al. European Association of Nuclear Medicine procedure guidelines for brain imaging using [(18)F]FDG. Eur J Nucl Med Mol Imaging 2002;29:BP43–8.PubMed
2.
go back to reference Kuwert T, Bartenstein P, Grünwald F, et al. Clinical value of positron emission tomography in neuromedicine. Position paper on results of an interdisciplinary consensus conference. Nervenarzt 1989;69:1045–160.CrossRef Kuwert T, Bartenstein P, Grünwald F, et al. Clinical value of positron emission tomography in neuromedicine. Position paper on results of an interdisciplinary consensus conference. Nervenarzt 1989;69:1045–160.CrossRef
4.
go back to reference Schelbert HR, Hoh CK, Royal HD, et al. Procedure guideline for tumor imaging using fluorine-18-FDG. Society of Nuclear Medicine. J Nucl Med 1998;39:1302–5.PubMed Schelbert HR, Hoh CK, Royal HD, et al. Procedure guideline for tumor imaging using fluorine-18-FDG. Society of Nuclear Medicine. J Nucl Med 1998;39:1302–5.PubMed
5.
go back to reference Society of Nuclear Medicine Brain Imaging Council. Ethical clinical practice of functional brain imaging. J Nucl Med 1996;37:1256–9. Society of Nuclear Medicine Brain Imaging Council. Ethical clinical practice of functional brain imaging. J Nucl Med 1996;37:1256–9.
6.
go back to reference Messa C, Fazio F, Costa DC, Ell PJ. Clinical brain radionuclide imaging. Semin Nucl Med 1995;25:111–43.CrossRefPubMed Messa C, Fazio F, Costa DC, Ell PJ. Clinical brain radionuclide imaging. Semin Nucl Med 1995;25:111–43.CrossRefPubMed
7.
go back to reference Setani K, Schreckenberger M, Sabri O, et al. Comparison of different methods for attenuation correction in brain PET: effect on the calculation of the metabolic rate of glucose. Nuklearmedizin 2000;39:50–5.PubMed Setani K, Schreckenberger M, Sabri O, et al. Comparison of different methods for attenuation correction in brain PET: effect on the calculation of the metabolic rate of glucose. Nuklearmedizin 2000;39:50–5.PubMed
8.
go back to reference Herholz K, Salmon E, Perani D, et al. Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage 2002;17:302–16.CrossRefPubMed Herholz K, Salmon E, Perani D, et al. Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage 2002;17:302–16.CrossRefPubMed
9.
go back to reference Herholz K, Carter SF, Jones M. Positron emission tomography imaging in dementia. Br J Radiol 2007;80:S160–7.CrossRefPubMed Herholz K, Carter SF, Jones M. Positron emission tomography imaging in dementia. Br J Radiol 2007;80:S160–7.CrossRefPubMed
10.
go back to reference Mosconi L, Tsui WH, Herholz K, et al. Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer’s disease, and other dementias. J Nucl Med 2008;49:390–8.CrossRefPubMed Mosconi L, Tsui WH, Herholz K, et al. Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer’s disease, and other dementias. J Nucl Med 2008;49:390–8.CrossRefPubMed
11.
go back to reference Dubois B, Feldman HH, Jacova C, et al. Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 2007;6:734–46.CrossRefPubMed Dubois B, Feldman HH, Jacova C, et al. Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 2007;6:734–46.CrossRefPubMed
12.
go back to reference Kaschten B, Stevenaert A, Sadzot B, et al. Preoperative evaluation of 54 gliomas by PET with fluorine-18-fluorodeoxyglucose and/or carbon-11-methionine. J Nucl Med 1998;39:778–85.PubMed Kaschten B, Stevenaert A, Sadzot B, et al. Preoperative evaluation of 54 gliomas by PET with fluorine-18-fluorodeoxyglucose and/or carbon-11-methionine. J Nucl Med 1998;39:778–85.PubMed
13.
go back to reference Henry TR, Votaw JR. The role of positron emission tomography with [18F]fluorodeoxyglucose in the evaluation of the epilepsies. Neuroimaging Clin N Am 2004;14:517–35.CrossRefPubMed Henry TR, Votaw JR. The role of positron emission tomography with [18F]fluorodeoxyglucose in the evaluation of the epilepsies. Neuroimaging Clin N Am 2004;14:517–35.CrossRefPubMed
14.
go back to reference Van Paesschen W, Dupont P, Sunaert S, Goffin K, Van Laere K. The use of SPECT and PET in routine clinical practice in epilepsy. Curr Opin Neurol 2007;20:194–202.CrossRefPubMed Van Paesschen W, Dupont P, Sunaert S, Goffin K, Van Laere K. The use of SPECT and PET in routine clinical practice in epilepsy. Curr Opin Neurol 2007;20:194–202.CrossRefPubMed
15.
go back to reference Eckert T, Barnes A, Dhawan V, Frucht S, Gordon MF, Feigin AS, et al. FDG PET in the differential diagnosis of parkinsonian disorders. Neuroimage 2005;26:912–21.CrossRefPubMed Eckert T, Barnes A, Dhawan V, Frucht S, Gordon MF, Feigin AS, et al. FDG PET in the differential diagnosis of parkinsonian disorders. Neuroimage 2005;26:912–21.CrossRefPubMed
16.
go back to reference Eckert T, Tang C, Ma Y, Brown N, Lin T, Frucht S, et al. Abnormal metabolic networks in atypical parkinsonism. Mov Disord 2008;5:727–33.CrossRef Eckert T, Tang C, Ma Y, Brown N, Lin T, Frucht S, et al. Abnormal metabolic networks in atypical parkinsonism. Mov Disord 2008;5:727–33.CrossRef
17.
go back to reference Hasselbalch SG, Knudsen GM, Videbaek C, et al. No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans. Diabetes 1999;48:1915–21.CrossRefPubMed Hasselbalch SG, Knudsen GM, Videbaek C, et al. No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans. Diabetes 1999;48:1915–21.CrossRefPubMed
18.
go back to reference Cranston I, Marsden P, Matyka K, et al. Regional differences in cerebral blood flow and glucose utilization in diabetic man: the effect of insulin. J Cereb Blood Flow Metab 1998;18:130–40.CrossRefPubMed Cranston I, Marsden P, Matyka K, et al. Regional differences in cerebral blood flow and glucose utilization in diabetic man: the effect of insulin. J Cereb Blood Flow Metab 1998;18:130–40.CrossRefPubMed
19.
go back to reference Spanaki MV, Siegel H, Kopylev L, et al. The effect of vigabatrin (gamma-vinyl GabA) on cerebral blood flow and metabolism. Neurology 1999;53:1518–22.PubMed Spanaki MV, Siegel H, Kopylev L, et al. The effect of vigabatrin (gamma-vinyl GabA) on cerebral blood flow and metabolism. Neurology 1999;53:1518–22.PubMed
20.
go back to reference Berding G, Odin P, Brooks DJ, et al. Resting regional cerebral glucose metabolism in advanced Parkinson´s disease studied in the off and on conditions with [18F]FDG-PET. Mov Disord 2001;6:1014–22.CrossRef Berding G, Odin P, Brooks DJ, et al. Resting regional cerebral glucose metabolism in advanced Parkinson´s disease studied in the off and on conditions with [18F]FDG-PET. Mov Disord 2001;6:1014–22.CrossRef
21.
go back to reference Felgin A, Fukuda M, Dhawan V, et al. Metabolic correlates of levodopa response in Parkinson´s disease. Neurology 2001;57:2083–8. Felgin A, Fukuda M, Dhawan V, et al. Metabolic correlates of levodopa response in Parkinson´s disease. Neurology 2001;57:2083–8.
22.
go back to reference Ruotsalainen U, Suhonen-Polvi H, Eronen E, et al. Estimated radiation dose to the newborn in FDG-PET studies. J Nucl Med 1996;37:387–93.PubMed Ruotsalainen U, Suhonen-Polvi H, Eronen E, et al. Estimated radiation dose to the newborn in FDG-PET studies. J Nucl Med 1996;37:387–93.PubMed
23.
go back to reference Wu T-H, Huang Y-H, Lee JJS, Wang S-Y, Wang S-C, Su C-T, et al. Radiation exposure during transmission measurements: comparison between CT- and germanium-based techniques with a current PET scanner. Eur J Nucl Med Mol Imaging 2004;31:38–43.CrossRefPubMed Wu T-H, Huang Y-H, Lee JJS, Wang S-Y, Wang S-C, Su C-T, et al. Radiation exposure during transmission measurements: comparison between CT- and germanium-based techniques with a current PET scanner. Eur J Nucl Med Mol Imaging 2004;31:38–43.CrossRefPubMed
24.
go back to reference Chen WP, Matsunari I, Noda A, et al. Rapid scanning protocol for brain (18)F-FDG PET: a validation study. J Nucl Med 2005;46:1633–41.PubMed Chen WP, Matsunari I, Noda A, et al. Rapid scanning protocol for brain (18)F-FDG PET: a validation study. J Nucl Med 2005;46:1633–41.PubMed
25.
go back to reference Lucignani G, Schmidt KC, Moresco RM, et al. Measurement of regional cerebral glucose utilization with fluorine-18-FDG and PET in heterogeneous tissue: theoretical considerations and practical procedure. J Nucl Med 1993;34:360–9.PubMed Lucignani G, Schmidt KC, Moresco RM, et al. Measurement of regional cerebral glucose utilization with fluorine-18-FDG and PET in heterogeneous tissue: theoretical considerations and practical procedure. J Nucl Med 1993;34:360–9.PubMed
26.
go back to reference Phelps ME. PET: the merging of biology and imaging into molecular imaging. J Nucl Med 2000;41:661–81.PubMed Phelps ME. PET: the merging of biology and imaging into molecular imaging. J Nucl Med 2000;41:661–81.PubMed
27.
go back to reference Henry TR, Engel J Jr, Mazziotta JC. Clinical evaluation of interictal fluorine-18-fluordeoxyglucose PET in partial epilepsy. J Nucl Med 1993;34:1892–998.PubMed Henry TR, Engel J Jr, Mazziotta JC. Clinical evaluation of interictal fluorine-18-fluordeoxyglucose PET in partial epilepsy. J Nucl Med 1993;34:1892–998.PubMed
28.
go back to reference Schreckenberger M, Spetzger U, Sabri O, et al. Localisation of motor areas in brain tumour patients: a comparison of preoperative 18-FDG-PET and intraoperative cortical electrostimulation. Eur J Nucl Med 2001;28:1394–403.CrossRefPubMed Schreckenberger M, Spetzger U, Sabri O, et al. Localisation of motor areas in brain tumour patients: a comparison of preoperative 18-FDG-PET and intraoperative cortical electrostimulation. Eur J Nucl Med 2001;28:1394–403.CrossRefPubMed
29.
go back to reference Herholz K, Pietrzyk U, Karbe H, et al. Individual metabolic anatomy of repeating words demonstrated by MRI-guided positron emission tomography. Neurosci Lett 1994;182:47–50.CrossRefPubMed Herholz K, Pietrzyk U, Karbe H, et al. Individual metabolic anatomy of repeating words demonstrated by MRI-guided positron emission tomography. Neurosci Lett 1994;182:47–50.CrossRefPubMed
30.
go back to reference Minoshima S, Koeppe RA, Mintun MA, et al. Automated detection of the intercommissural line for stereotactic localization of functional brain images. J Nucl Med 1993;34:322–9.PubMed Minoshima S, Koeppe RA, Mintun MA, et al. Automated detection of the intercommissural line for stereotactic localization of functional brain images. J Nucl Med 1993;34:322–9.PubMed
31.
go back to reference Graham MM, Muzi M, Spence AM, et al. The FDG lumped constant in normal human brain. J Nucl Med 2002;43:1157–66.PubMed Graham MM, Muzi M, Spence AM, et al. The FDG lumped constant in normal human brain. J Nucl Med 2002;43:1157–66.PubMed
32.
go back to reference Minoshima S, Frey KA, Koeppe RA, et al. A diagnostic approach in Alzheimer’s disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. J Nucl Med 1995;36:1238–48.PubMed Minoshima S, Frey KA, Koeppe RA, et al. A diagnostic approach in Alzheimer’s disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. J Nucl Med 1995;36:1238–48.PubMed
33.
go back to reference Frackowiak RSJ, Friston KJ, Frith CD, Dolan RJ, Mazziotta JC. Human brain function. London: Academic Press; 1997. Frackowiak RSJ, Friston KJ, Frith CD, Dolan RJ, Mazziotta JC. Human brain function. London: Academic Press; 1997.
34.
go back to reference Drzezga A, Arnold S, Minoshima S, et al. F-18 FDG-PET studies in patients with extratemporal and temporal epilepsy: evaluation of an observer-independent analysis. J Nucl Med 1999;40:737–46.PubMed Drzezga A, Arnold S, Minoshima S, et al. F-18 FDG-PET studies in patients with extratemporal and temporal epilepsy: evaluation of an observer-independent analysis. J Nucl Med 1999;40:737–46.PubMed
35.
go back to reference Cook GJ, Maisey MN, Fogelman I. Normal variants, artefacts and interpretative pitfalls in PET imaging with 18-fluoro-2-deoxyglucose and carbon-11 methionine. Eur J Nucl Med 1999;26:1363–78.CrossRefPubMed Cook GJ, Maisey MN, Fogelman I. Normal variants, artefacts and interpretative pitfalls in PET imaging with 18-fluoro-2-deoxyglucose and carbon-11 methionine. Eur J Nucl Med 1999;26:1363–78.CrossRefPubMed
Metadata
Title
EANM procedure guidelines for PET brain imaging using [18F]FDG, version 2
Authors
Andrea Varrone
Susanne Asenbaum
Thierry Vander Borght
Jan Booij
Flavio Nobili
Kjell Någren
Jacques Darcourt
Özlem L. Kapucu
Klaus Tatsch
Peter Bartenstein
Koen Van Laere
Publication date
01-12-2009
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 12/2009
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-009-1264-0

Other articles of this Issue 12/2009

European Journal of Nuclear Medicine and Molecular Imaging 12/2009 Go to the issue