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Current Diabetes Reports
Published in: Current Diabetes Reports 5/2013

01-10-2013 | Transplantation (A Pileggi, Section Editor)

Making β Cells from Adult Cells Within the Pancreas

Authors: Philippe A. Lysy, Gordon C. Weir, Susan Bonner-Weir

Published in: Current Diabetes Reports | Issue 5/2013

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Abstract

Cell therapy is currently considered as a potential therapeutic alternative to traditional treatments of diabetes. Islet and whole pancreas transplantations provided the proof-of-concept of glucose homeostasis restoration after replenishment of the deficiency of β cells responsible for the disease. Current limitations of these procedures have led to the search for strategies targeting replication of pre-existing β cells or transdifferentiation of progenitors and adult cells. These investigations revealed an unexpected plasticity towards β cells of adult cells residing in pancreatic epithelium (eg, acinar, duct, and α cells). Here we discuss recent developments in β-cell replication and β-cell transdifferentiation of adult epithelial pancreatic cells, with an emphasis on techniques with a potential for clinical translation.
Literature
1.
• Barton FB et al. Improvement in outcomes of clinical islet transplantation: 1999–2010. Diabetes Care. 2012;35:1436–45. This paper describes the recent progresses of islet transplantation: increased insulin independence at 3 years post-transplant (44%) and islet graft function (c-peptide secretion), and decreased adverse events in the years 2007–2010.PubMedCrossRef
2.
Maglione M, Ploeg RJ, Friend PJ. Donor risk factors, retrieval technique, preservation and ischemia/reperfusion injury in pancreas transplantation. Curr Opin Org Transplant. 2013;18:83–8.CrossRef
3.
Kroon E et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nature Biotechnol. 2008;26:443–52.CrossRef
4.
Rezania A et al. Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice. Diabetes. 2012;61:2016–29.PubMedCrossRef
5.
Schroeder IS. Potential of pluripotent stem cells for diabetes therapy. Curr Diabetes Rep. 2012;12:490–8.CrossRef
6.
O'Sullivan ES, et al. Islets transplanted in immunoisolation devices: a review of the progress and the challenges that remain. Endocrine Reviews. 2011;32:627–44.
7.
•• Pan FC, Wright C. Pancreas organogenesis: from bud to plexus to gland. Dev Dyn: Off Publ Am Assoc Anatomists. 2011;240:530–65. Thorough overview of pancreas embryogenesis with insights into molecular and cellular aspects of organ development.
8.
•• Bar-Nur O et al. Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet Beta cells. Cell Stem Cell. 2011;9:17–23. This work highlights the importance of epigenetic memory in cell reprogramming and the benefits of using of pancreatic cells for β-cell differentiation.PubMedCrossRef
9.
Avrahami D, Kaestner KH. Epigenetic regulation of pancreas development and function. Sem Cell Dev Biol. 2012;23:693–700.CrossRef
10.
Sokal EM. From hepatocytes to stem and progenitor cells for liver regenerative medicine: advances and clinical perspectives. Cell Prolif. 2011;44 Suppl 1:39–43.PubMedCrossRef
11.
Shapiro AM. State of the art of clinical islet transplantation and novel protocols of immunosuppression. Curr Diabetes Rep. 2011;11:345–54.
12.
13.
Naujok O, Lenzen S. A critical re-evaluation of CD24-positivity of human embryonic stem cells differentiated into pancreatic progenitors. Stem Cell Rev. 2012;8:779–91.PubMedCrossRef
14.
•• Kelly OG et al. Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells. Nature Biotechnol. 2011;29:750–6. This paper shows the possibility to obtain glucose-responsive β-like cells in vivo after transplantation of FACS-sorted CD149 + pancreatic endoderm cells derived from human ESCs. Interestingly, purified endocrine cells preferentially differentiated in vivo in α cells.CrossRef
15.
Wagner W. Implications of long-term culture for mesenchymal stem cells: genetic defects or epigenetic regulation? Stem Cell Res Ther. 2012;3:54.PubMedCrossRef
16.
Prockop DJ, Olson SD. Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions. Blood. 2007;109:3147–51.PubMedCrossRef
17.
Desgraz R, Bonal C, Herrera PL. beta-cell regeneration: the pancreatic intrinsic faculty. TEM. 2011;22:34–43.PubMed
18.
Meier JJ et al. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes. 2008;57:1584–94.PubMedCrossRef
19.
Gregg BE et al. Formation of a human beta-cell population within pancreatic islets is set early in life. J Clin Endocrinol Metab. 2012;97:3197–206.PubMedCrossRef
20.
Perl S et al. Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating. J Clin Endocrinol Metab. 2010;95:E234–9.PubMedCrossRef
21.
Reers C et al. Impaired islet turnover in human donor pancreata with aging. Eur J Endocrinol. 2009;160:185–91.PubMedCrossRef
22.
Caballero F, et al. Birth and death of human beta-cells in pancreas from cadaver donors, autopsies, surgical specimens, and islets transplanted into mice. Cell Transplant. 2013. doi:10.​3727/​096368912X659916​.
23.
Rahier J et al. Pancreatic beta-cell mass in European subjects with type 2 diabetes. Diabetes Obes Metabol. 2008;10 Suppl 4:32–42.CrossRef
24.
Hanley SC et al. {beta}-Cell mass dynamics and islet cell plasticity in human type 2 diabetes. Endocrinology. 2010;151:1462–72.PubMedCrossRef
25.
Rieck S, Kaestner KH. Expansion of beta-cell mass in response to pregnancy. TEM. 2010;21:151–8.PubMed
26.
Butler AE et al. Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy. Diabetologia. 2010;53:2167–76.PubMedCrossRef
27.
Kim H et al. Serotonin regulates pancreatic beta cell mass during pregnancy. Nat Med. 2010;16:804–8.PubMedCrossRef
28.
Zhang H et al. Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen. Diabetes. 2010;59:143–52.PubMedCrossRef
29.
Davis DB et al. FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation. Mol Endocrinol. 2010;24:1822–34.PubMedCrossRef
30.
Karnik SK et al. Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus. Science. 2007;318:806–9.PubMedCrossRef
31.
• Jacovetti C et al. MicroRNAs contribute to compensatory beta cell expansion during pregnancy and obesity. J Clin Invest. 2012;122:3541–51. This paper is the first report of the role of microRNAs in regulation of β-cell proliferation, offering a new area of investigation.PubMedCrossRef
32.
Cozar-Castellano I et al. Molecular control of cell cycle progression in the pancreatic beta-cell. Endocr Rev. 2006;27:356–70.PubMedCrossRef
33.
Kulkarni RN et al. Human beta-cell proliferation and intracellular signaling: driving in the dark without a road map. Diabetes. 2012;61:2205–13.PubMedCrossRef
34.
Cozar-Castellano I et al. Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1. Diabetes. 2004;53:149–59.PubMedCrossRef
35.
Fiaschi-Taesch N et al. Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo. Diabetes. 2009;58:882–93.PubMedCrossRef
36.
Firestone AJ, Chen JK. Controlling destiny through chemistry: small-molecule regulators of cell fate. ACS Chem Biol. 2010;5:15–34.PubMedCrossRef
37.
Vetere A, Wagner BK. Chemical methods to induce Beta-cell proliferation. Int J Endocrinol. 2012;2012:925143.PubMed
38.
• Annes JP et al. Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication. Proc Natl Acad Sci U S A. 2012;109:3915–20. The authors show a successful high-throughput small molecule screening for stimulating proliferation of primary mammalian β cells through modulation of adenosine pathway.PubMedCrossRef
39.
Andersson O et al. Adenosine signaling promotes regeneration of pancreatic beta cells in vivo. Cell Metabol. 2012;15:885–94.CrossRef
40.
Rulifson IC et al. Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci U S A. 2007;104:6247–52.PubMedCrossRef
41.
Elghazi L et al. Regulation of beta-cell mass and function by the Akt/protein kinase B signalling pathway. Diabetes Obes Metabol. 2007;9 Suppl 2:147–57.CrossRef
42.
Welters HJ, Kulkarni RN. Wnt signaling: relevance to beta-cell biology and diabetes. TEM. 2008;19:349–55.PubMed
43.
Stukenbrock H et al. 9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication. J Med Chem. 2008;51:2196–207.PubMedCrossRef
44.
• Kassem S et al. Large islets, beta-cell proliferation, and a glucokinase mutation. N Engl J Med. 2010;362:1348–50. This paper is an example of translation from bedside to bench that offers possibilities to study islet proliferation.PubMedCrossRef
45.
Terauchi Y et al. Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance. J Clin Invest. 2007;117:246–57.PubMedCrossRef
46.
Nakamura A et al. Impact of small-molecule glucokinase activator on glucose metabolism and beta-cell mass. Endocrinology. 2009;150:1147–54.PubMedCrossRef
47.
Nakamura A et al. Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions. Diabetologia. 2012;55:1745–54.PubMedCrossRef
48.
Matschinsky FM et al. Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects. Handb Exp Pharmacol. 2011;203:357–401.PubMedCrossRef
49.
Zhang X, et al. Dose selection using a semi-mechanistic integrated glucose-insulin-glucagon model: designing phase 2 trials for a novel oral glucokinase activator. J Pharmacokin Pharmacodynam. 2012.
50.
Garber AJ. Incretin effects on beta-cell function, replication, and mass: the human perspective. Diabetes Care. 2011;34 Suppl 2:S258–63.PubMedCrossRef
51.
Xu G et al. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes. 1999;48:2270–6.PubMedCrossRef
52.
Sturis J et al. GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics. Br J Pharmacol. 2003;140:123–32.PubMedCrossRef
53.
Tian L et al. Comparison of exendin-4 on beta-cell replication in mouse and human islet grafts. Transplant Int. 2011;24:856–64.CrossRef
54.
Talchai C et al. Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure. Cell. 2012;150:1223–34.PubMedCrossRef
55.
Jonas JC et al. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem. 1999;274:14112–21.PubMedCrossRef
56.
Laybutt DR et al. Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes. J Biolog Chem. 2003;278:2997–3005.CrossRef
57.
Russ HA et al. In vitro proliferation of cells derived from adult human beta-cells revealed by cell-lineage tracing. Diabetes. 2008;57:1575–83.PubMedCrossRef
58.
Russ HA et al. Epithelial-mesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells. PLoS One. 2009;4:e6417.PubMedCrossRef
59.
Russ HA et al. Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro. PLoS One. 2011;6:e25566.PubMedCrossRef
60.
• Bar Y et al. Redifferentiation of expanded human pancreatic beta-cell-derived cells by inhibition of the NOTCH pathway. J Biol Chem. 2012;287:17269–80. This paper continues the work of the Efrat group showing high levels of β-cell differentiation of epithelial-mesenchymal transition cells obtained after expansion of human β cells.PubMedCrossRef
61.
Bonner-Weir S et al. Beta-cell growth and regeneration: replication is only part of the story. Diabetes. 2010;59:2340–8.PubMedCrossRef
62.
Xu X et al. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell. 2008;132:197–207.PubMedCrossRef
63.
Kopp JL et al. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development. 2011;138:653–65.PubMedCrossRef
64.
Furuyama K et al. Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet. 2011;43:34–41.PubMedCrossRef
65.
Solar M et al. Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. Dev Cell. 2009;17:849–60.PubMedCrossRef
66.
Inada A et al. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci U S A. 2008;105:19915–9.PubMedCrossRef
67.
Criscimanna A, et al. Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice. Gastroenterology. 2011;141:1451–62
68.
Nakamura K et al. Pancreatic beta-cells are generated by neogenesis from non-beta-cells after birth. Biomed Res. 2011;32:167–74.PubMedCrossRef
69.
Pan FC et al. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development. 2013;140:751–64.PubMedCrossRef
70.
Ouziel-Yahalom L, et al. Ductal heterogeneity suggests a subpopulation serves as postantal pancreatic progenitors. Diabetes. 2010;59(Suppl 1):A25.
71.
• Reinert RB et al. Tamoxifen-induced Cre-loxP recombination is prolonged in pancreatic islets of adult mice. PLoS One. 2012;7:e33529. This paper points out the need for some caution in interpreting inducible Cre-Lox results since there is perdurance of tamoxifen often for weeks.PubMedCrossRef
72.
Meier JJ et al. Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased beta-cell turnover. Diabetes Care. 2006;29:1554–9.PubMedCrossRef
73.
Yatoh S et al. Differentiation of affinity-purified human pancreatic duct cells to beta-cells. Diabetes. 2007;56:1802–9.PubMedCrossRef
74.
Baertschiger RM et al. Mesenchymal stem cells derived from human exocrine pancreas express transcription factors implicated in beta-cell development. Pancreas. 2008;37:75–84.PubMedCrossRef
75.
Seeberger KL et al. Expansion of mesenchymal stem cells from human pancreatic ductal epithelium. Lab Invest. 2006;86:141–53.PubMedCrossRef
76.
Lysy P et al. Partial transition towards a mesenchymal phenotype allows human panreatic duct cells to proliferate while showing a beta-cell differentiation potential in vitro. Horm Res Pediatrics. 2011;76(Suppl2):34.
77.
•• Collombat P et al. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell. 2009;138:449–62. An important paper illustrating the plasticity of islet endocrine cells. The expression of a single transcription factor in α cells drives them to form β cells, which in turn provokes hypoglycemia that then drives the formation of new α cells.PubMedCrossRef
78.
Baeyens L et al. In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia. 2005;48:49–57.PubMedCrossRef
79.
Bertelli E, Bendayan M. Intermediate endocrine-acinar pancreatic cells in duct ligation conditions. Am J Physiol. 1997;273(5 Pt 1):C1641–9.PubMed
80.
Hesselson D, Anderson RM, Stainier DY. Suppression of Ptf1a activity induces acinar-to-endocrine conversion. Curr Biol. 2011;21:712–7.PubMedCrossRef
81.
Desai BM et al. Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration. J Clin Invest. 2007;117:971–7.PubMedCrossRef
82.
Houbracken I, et al. Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas. Gastroenterology. 2011;141:731–41, 741 e1–4.
83.
Zhou Q et al. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature. 2008;455:627–32.PubMedCrossRef
84.
Wang AY et al. Comparison of adenoviral and adeno-associated viral vectors for pancreatic gene delivery in vivo. Human Gene Therapy. 2004;15:405–13.PubMedCrossRef
85.
Kim D et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell. 2009;4:472–6.PubMedCrossRef
86.
Warren L et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell. 2010;7:618–30.PubMedCrossRef
87.
Smith SB et al. Rfx6 directs islet formation and insulin production in mice and humans. Nature. 2010;463:775–80.PubMedCrossRef
88.
Zhou Q et al. A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell. 2007;13:103–14.PubMedCrossRef
89.
Gifford CA, Meissner A. Epigenetic obstacles encountered by transcription factors: reprogramming against all odds. Curr Opin Genet Dev. 2012;22:409–15.PubMedCrossRef
90.
Collombat P et al. Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. J Clin Invest. 2007;117:961–70.PubMedCrossRef
91.
•• Thorel F et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature. 2010;464:1149–54. This study confirms the plasticity of islet endocrine cells in the context of extensive β-cell failure.PubMedCrossRef
92.
Yang YP et al. Context-specific alpha- to-beta-cell reprogramming by forced Pdx1 expression. Genes Dev. 2011;25:1680–5.PubMedCrossRef
93.
Gianani R. Beta cell regeneration in human pancreas. Sem Immunopathol. 2011;33:23–7.CrossRef
94.
Rezania A et al. Production of functional glucagon-secreting alpha-cells from human embryonic stem cells. Diabetes. 2011;60:239–47.PubMedCrossRef
95.
Fomina-Yadlin D et al. Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proc Natl Acad Sci U S A. 2010;107:15099–104.PubMedCrossRef
96.
Saisho Y et al. Ongoing beta-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes. Diabetes. 2011;60:848–56.PubMedCrossRef
97.
Jones RJ et al. Assessment of aldehyde dehydrogenase in viable cells. Blood. 1995;85:2742–6.PubMed
98.
Gasparetto M et al. Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development. Exp Hematol. 2012;40:318–29 e2.PubMedCrossRef
99.•
Rovira M et al. Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas. Proc Natl Acad Sci U S A. 2010;107:75–80. This paper suggests role of centroacinar cells in the adult rodent pancreas as facultative progenitors with β-cell differentiation potential.PubMedCrossRef
100.
Hayashi KY et al. Differentiation and proliferation of endocrine cells in the regenerating rat pancreas after 90% pancreatectomy. Arch Histol Cytol. 2003;66:163–74.PubMedCrossRef
101.
Ioannou M et al. ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Dev Biol. 2013;374:153–63.PubMedCrossRef
102.
Seaberg RM et al. Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat Biotechnol. 2004;22:1115–24.PubMedCrossRef
103.
• Smukler SR et al. The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell. 2011;8:281–93. This paper extends the previous work of this group on the isolation from both islet and exocrine tissues of a progenitor cell with stem-like characteristics, in adult mouse and human pancreas..PubMedCrossRef
104.
Hald J et al. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Diabetologia. 2012;55:154–65.PubMedCrossRef
Metadata
Title
Making β Cells from Adult Cells Within the Pancreas
Authors
Philippe A. Lysy
Gordon C. Weir
Susan Bonner-Weir
Publication date
01-10-2013
Publisher
Springer US
Published in
Current Diabetes Reports / Issue 5/2013
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-013-0400-1

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