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Insights into Imaging
Published in: Insights into Imaging 1/2023

Open Access 01-12-2023 | Magnetic Resonance Imaging | Original Article

Value of placental virtual magnetic resonance elastography and intravoxel incoherent motion-based diffusion and perfusion in predicting adverse outcomes of small-for-gestational-age infants

Authors: Jing Deng, Yuwei Cao, Yao Lu, Jiacheng Song, Aining Zhang, Meng Zhao, Xin Zhou, Xihu Mu, Feifei Qu, Feiyun Wu, Ting Chen

Published in: Insights into Imaging | Issue 1/2023

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Abstract

Objective

It is critical to early monitor and manage small-for-gestational age (SGA) infants with truly adverse outcomes not detected by conventional methods. We aimed to explore the value of diffusion-weighted imaging (DWI)-based virtual magnetic resonance elastography (vMRE) and intravoxel incoherent motion (IVIM)-based biexponential and stretched exponential parameters in predicting adverse outcomes of SGA infants.

Methods

Twenty SGA infants with adverse outcomes and forty without adverse outcomes were included in this prospective study. One DWI-based vMRE parameter [the stiffness value (μdiff)], five IVIM–based parameters [true diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), diffusion distribution coefficient (DDC), and diffusion heterogeneity index (Alpha)] and apparent diffusion coefficient (ADC) were calculated and compared between groups. The predictive efficiency was compared by the logistic regression analysis and receiver operating characteristic curve analysis. The relationship between the μdiff value with gestational age was also evaluated.

Results

The placental μdiff value was remarkably higher, and the f, DDC, and ADC values were considerably lower in the SGA infants with adverse outcomes compared with those without adverse outcomes. The μdiff and f value were predictive risk factors for SGA infants with adverse outcomes. A combined predictive model (μdiff and f) improved the predictive efficacy. Moreover, there was no statistically significant correlation between the placental stiffness value and gestational age.

Conclusions

Functional MRI parameters to quantify placenta elastography and microcirculation in SGA patients. This might be a useful tool to assess placental function and a vital non-invasive supplement for predicting adverse outcomes of SGA infants.

Critical relevance statement

This prospective study shows DWI-based virtual magnetic resonance elastography and intravoxel incoherent motion-based functional parameters to quantify placenta elastography and microcirculation in small-for-gestational-age patients, which could complement existing non-invasive methods for monitoring and predicting neonatal perinatal adverse outcome.

Key points

• vMRE is an emerging non-invasive imaging technique for evaluating placenta stiffness.
• SGA infants with adverse outcome have stiffer placental elasticity and lower microcirculation.
• Risk factors combination displayed better efficacy in predicting adverse outcomes of SGA.

Graphical Abstract

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Metadata
Title
Value of placental virtual magnetic resonance elastography and intravoxel incoherent motion-based diffusion and perfusion in predicting adverse outcomes of small-for-gestational-age infants
Authors
Jing Deng
Yuwei Cao
Yao Lu
Jiacheng Song
Aining Zhang
Meng Zhao
Xin Zhou
Xihu Mu
Feifei Qu
Feiyun Wu
Ting Chen
Publication date
01-12-2023
Publisher
Springer Vienna
Published in
Insights into Imaging / Issue 1/2023
Electronic ISSN: 1869-4101
DOI
https://doi.org/10.1186/s13244-023-01503-9

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