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Published in: Acta Neurochirurgica 2/2022

Open Access 01-02-2022 | Magnetic Resonance Imaging | Original Article - Brain Tumors

Radiographic markers of breast cancer brain metastases: relation to clinical characteristics and postoperative outcome

Authors: Anna Michel, Thiemo Dinger, Marvin Darkwah Oppong, Laurèl Rauschenbach, Cornelius Deuschl, Yahya Ahmadipour, Daniela Pierscianek, Karsten Wrede, Jörg Hense, Christoph Pöttgen, Antonella Iannaccone, Rainer Kimmig, Ulrich Sure, Ramazan Jabbarli

Published in: Acta Neurochirurgica | Issue 2/2022

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Abstract

Objective

Occurrence of brain metastases BM is associated with poor prognosis in patients with breast cancer (BC). Magnetic resonance imaging (MRI) is the standard of care in the diagnosis of BM and determines further treatment strategy. The aim of the present study was to evaluate the association between the radiographic markers of BCBM on MRI with other patients’ characteristics and overall survival (OS).

Methods

We included 88 female patients who underwent BCBM surgery in our institution from 2008 to 2019. Data on demographic, clinical, and histopathological characteristics of the patients and postoperative survival were collected from the electronic health records. Radiographic features of BM were assessed upon the preoperative MRI. Univariable and multivariable analyses were performed.

Results

The median OS was 17 months. Of all evaluated radiographic markers of BCBM, only the presence of necrosis was independently associated with OS (14.5 vs 22.5 months, p = 0.027). In turn, intra-tumoral necrosis was more often in individuals with shorter time interval between BC and BM diagnosis (< 3 years, p = 0.035) and preoperative leukocytosis (p = 0.022). Moreover, dural affection of BM was more common in individuals with positive human epidermal growth factor receptor 2 status (p = 0.015) and supratentorial BM location (p = 0.024).

Conclusion

Intra-tumoral necrosis demonstrated significant association with OS after BM surgery in patients with BC. The radiographic pattern of BM on the preoperative MRI depends on certain tumor and clinical characteristics of patients.
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Metadata
Title
Radiographic markers of breast cancer brain metastases: relation to clinical characteristics and postoperative outcome
Authors
Anna Michel
Thiemo Dinger
Marvin Darkwah Oppong
Laurèl Rauschenbach
Cornelius Deuschl
Yahya Ahmadipour
Daniela Pierscianek
Karsten Wrede
Jörg Hense
Christoph Pöttgen
Antonella Iannaccone
Rainer Kimmig
Ulrich Sure
Ramazan Jabbarli
Publication date
01-02-2022
Publisher
Springer Vienna
Published in
Acta Neurochirurgica / Issue 2/2022
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-021-05026-4

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