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Published in: Journal of Cardiovascular Magnetic Resonance 1/2020

01-12-2020 | Magnetic Resonance Imaging | Research

Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation

Authors: Gordon A. Begg, Peter P. Swoboda, Rashed Karim, Tobias Oesterlein, Kawal Rhode, Arun V. Holden, John P. Greenwood, Eduard Shantsila, Gregory Y. H. Lip, Sven Plein, Muzahir H. Tayebjee

Published in: Journal of Cardiovascular Magnetic Resonance | Issue 1/2020

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Abstract

Background

Using cardiovascular magnetic resonance imaging (CMR), it is possible to detect diffuse fibrosis of the left ventricle (LV) in patients with atrial fibrillation (AF), which may be independently associated with recurrence of AF after ablation. By conducting CMR, clinical, electrophysiology and biomarker assessment we planned to investigate LV myocardial fibrosis in patients undergoing AF ablation.

Methods

LV fibrosis was assessed by T1 mapping in 31 patients undergoing percutaneous ablation for AF. Galectin-3, coronary sinus type I collagen C terminal telopeptide (ICTP), and type III procollagen N terminal peptide were measured with ELISA. Comparison was made between groups above and below the median for LV extracellular volume fraction (ECV), followed by regression analysis.

Results

On linear regression analysis LV ECV had significant associations with invasive left atrial pressure (Beta 0.49, P = 0.008) and coronary sinus ICTP (Beta 0.75, P < 0.001), which remained significant on multivariable regression.

Conclusion

LV fibrosis in patients with AF is associated with left atrial pressure and invasively measured levels of ICTP turnover biomarker.
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Metadata
Title
Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation
Authors
Gordon A. Begg
Peter P. Swoboda
Rashed Karim
Tobias Oesterlein
Kawal Rhode
Arun V. Holden
John P. Greenwood
Eduard Shantsila
Gregory Y. H. Lip
Sven Plein
Muzahir H. Tayebjee
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Journal of Cardiovascular Magnetic Resonance / Issue 1/2020
Electronic ISSN: 1532-429X
DOI
https://doi.org/10.1186/s12968-020-0603-y

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