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European Radiology
Published in: European Radiology 12/2020

01-12-2020 | Magnetic Resonance Imaging | Hepatobiliary-Pancreas

Does the change in volumetric functional MR metrics post-TACE predict histopathologic grading of hepatocellular carcinoma?

Authors: Sanaz Ameli, Mohammadreza Shaghaghi, Mounes Aliyari Ghasabeh, Pallavi Pandey, Bita Hazhirkarzar, Roya Rezvani Habibabadi, Maryam Ghadimi, Pegah Khoshpouri, Ankur Pandey, Ihab R. Kamel

Published in: European Radiology | Issue 12/2020

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Abstract

Objectives

To evaluate whether the change in volumetric ADC (vADC) and volumetric venous enhancement (vVE) after transarterial chemoembolization (TACE) can predict the histologic grading of hepatocellular carcinoma (HCC).

Materials and methods

This HIPPA-compliant retrospective study was approved by our institutional review board. The study population included 106 HCC patients (147 index lesions) who had MR imaging within 3 months before and after TACE and pathologic report of the HCC either by biopsy or liver transplantation/resection between 2001 and 2017. Volumetric measurements of venous enhancement (VE) and apparent diffusion coefficient (ADC) were performed on baseline and post-TACE MRI. The tumors were histologically classified into two low-grade and high-grade groups. The parameters between two groups were compared using bivariate and multivariate analyses.

Results

Median change in vADC, vVE, and absolute vADC skewness after TACE was higher in low-grade HCCs as compared with high-grade HCCs (p < 0.001, p = 0.005, p = 0.04, respectively). Combining ΔvADC, ΔvVE, and the etiology for background liver disease in multivariate analysis had the highest accuracy in distinguishing high-grade tumors (AUC = 91%).

Conclusion

ΔvADC and ΔvVE after TACE are potential predictors of HCC histopathological grading. Combining functional MRI biomarkers with the etiology of liver disease can enhance the accuracy in assessing degree of differentiation.

Key Points

• Change in volumetric functional MRI biomarkers after TACE can be a non-invasive method to evaluate tumor histopathology in HCC.
• The etiology of background liver disease might be a predictor of tumor degree of differentiation.
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Metadata
Title
Does the change in volumetric functional MR metrics post-TACE predict histopathologic grading of hepatocellular carcinoma?
Authors
Sanaz Ameli
Mohammadreza Shaghaghi
Mounes Aliyari Ghasabeh
Pallavi Pandey
Bita Hazhirkarzar
Roya Rezvani Habibabadi
Maryam Ghadimi
Pegah Khoshpouri
Ankur Pandey
Ihab R. Kamel
Publication date
01-12-2020
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 12/2020
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-020-07052-9

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