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European Radiology
Published in: European Radiology 8/2012

01-08-2012 | Hepatobiliary-Pancreas

Prediction of the histopathological grade of hepatocellular carcinoma using qualitative diffusion-weighted, dynamic, and hepatobiliary phase MRI

Authors: Chansik An, Mi-Suk Park, Hyae-Min Jeon, Yeo-Eun Kim, Woo-Suk Chung, Yong Eun Chung, Myeong-Jin Kim, Ki Whang Kim

Published in: European Radiology | Issue 8/2012

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Abstract

Objectives

To investigate the effectiveness of qualitative diffusion-weighted imaging (DWI), subtraction of unenhanced from arterial phase images, and hepatobiliary phase (HBP) images in estimating the histopathological grade of hepatocellular carcinoma (HCC).

Methods

We retrospectively reviewed gadoxetic acid–enhanced magnetic resonance images of 175 patients with 201 surgically resected HCCs. The signal intensity and its relationship with histopathological grade were assessed for each sequence and a combination of sequences.

Results

There was a tendency towards higher grades in tumours showing restricted diffusion on DWI (P < 0.001) or arterial enhancement on subtraction imaging (P <0.001), but not hepatocyte-defect on HBP images (P = 0.33). When lesions were divided into three groups based on combined findings on DWI and subtraction imaging, a linear trend was observed between group and grade (P < 0.001). The positive predictive value (PPV) of the combination of no restricted diffusion and no arterial enhancement in predicting well-differentiated HCC was 100%, higher than the PPV of individual findings on DWI (74%) or subtraction imaging (81%).

Conclusions

DWI and subtraction imaging are helpful for predicting the histopathological grade of HCC, especially when the two sequences are considered together.

Key Points

• Predicting the histopathological grade of hepatocellular carcinoma (HCC) preoperatively is important.
• Diffusion-weighted imaging (DWI) and subtraction imaging are recently developed MR techniques.
• Retrospective study showed DWI and subtraction imaging helps predict HCC grades.
• Management of patients with HCC becomes more appropriate.
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Metadata
Title
Prediction of the histopathological grade of hepatocellular carcinoma using qualitative diffusion-weighted, dynamic, and hepatobiliary phase MRI
Authors
Chansik An
Mi-Suk Park
Hyae-Min Jeon
Yeo-Eun Kim
Woo-Suk Chung
Yong Eun Chung
Myeong-Jin Kim
Ki Whang Kim
Publication date
01-08-2012
Publisher
Springer-Verlag
Published in
European Radiology / Issue 8/2012
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-012-2421-6

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