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Published in: Digestive Diseases and Sciences 2/2024

19-12-2023 | Magnetic Resonance Cholangio Pancreatography | Review

Imaging Diagnosis and Management of Fistulas in Pancreatitis

Authors: Manika Chhabra, Pankaj Gupta, Jimil Shah, Jayanta Samanta, Harshal Mandavdhare, Vishal Sharma, Saroj K. Sinha, Usha Dutta, Rakesh Kochhar

Published in: Digestive Diseases and Sciences | Issue 2/2024

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Abstract

Pancreatic fistula is a highly morbid complication of pancreatitis. External pancreatic fistulas result when pancreatic secretions leak externally into the percutaneous drains or external wound (following surgery) due to the communication of the peripancreatic collection with the main pancreatic duct (MPD). Internal pancreatic fistulas include communication of the pancreatic duct (directly or via intervening collection) with the pleura, pericardium, mediastinum, peritoneal cavity, or gastrointestinal tract. Cross-sectional imaging plays an essential role in the management of pancreatic fistulas. With the help of multiplanar imaging, fistulous tracts can be delineated clearly. Thin computed tomography sections and magnetic resonance cholangiopancreatography images may demonstrate the communication between MPD and pancreatic fluid collections or body cavities. Endoscopic retrograde cholangiography (ERCP) is diagnostic as well as therapeutic. In this review, we discuss the imaging diagnosis and management of various types of pancreatic fistulas with the aim to sensitize radiologists to timely diagnosis of this critical complication of pancreatitis.
Literature
1.
go back to reference Singh A, Aggarwal M, Garg R, Walsh M, Stevens T, Chahal P. Spontaneous Internal Pancreatic Fistulae Complicating Acute Pancreatitis. Am J Gastroenterol 2021;116:1381–1386.PubMed Singh A, Aggarwal M, Garg R, Walsh M, Stevens T, Chahal P. Spontaneous Internal Pancreatic Fistulae Complicating Acute Pancreatitis. Am J Gastroenterol 2021;116:1381–1386.PubMed
2.
go back to reference Larsen M, Kozarek R. Management of pancreatic ductal leaks and fistulae. J Gastroenterol Hepatol. 2014;29:1360–1370.PubMed Larsen M, Kozarek R. Management of pancreatic ductal leaks and fistulae. J Gastroenterol Hepatol. 2014;29:1360–1370.PubMed
3.
go back to reference Irani S, Gluck M, Ross A, et al. Resolving external pancreatic fistulas in patients with disconnected pancreatic duct syndrome: using rendezvous techniques to avoid surgery (with video). Gastrointest Endosc. 2012 Sep;76:586–93.e1–3. Irani S, Gluck M, Ross A, et al. Resolving external pancreatic fistulas in patients with disconnected pancreatic duct syndrome: using rendezvous techniques to avoid surgery (with video). Gastrointest Endosc. 2012 Sep;76:586–93.e1–3.
4.
go back to reference Ramachandran R, Radhan P, Ilanchezhian S, Mohan SV, Kumar M. MDCT in Diagnosis of Uncommon Fistulous Complications of Severe Pancreatitis-Pictorial Essay. Surgical Science. 2014;5:237–241. Ramachandran R, Radhan P, Ilanchezhian S, Mohan SV, Kumar M. MDCT in Diagnosis of Uncommon Fistulous Complications of Severe Pancreatitis-Pictorial Essay. Surgical Science. 2014;5:237–241.
5.
go back to reference Gupta P, Madhusudhan KS, Padmanabhan A, Khera PS. Indian College of Radiology and Imaging Consensus Guidelines on Interventions in Pancreatitis. Indian J Radiol Imaging. 2022;32:339–354.PubMedPubMedCentral Gupta P, Madhusudhan KS, Padmanabhan A, Khera PS. Indian College of Radiology and Imaging Consensus Guidelines on Interventions in Pancreatitis. Indian J Radiol Imaging. 2022;32:339–354.PubMedPubMedCentral
6.
go back to reference Ho H, Frey CF. Gastrointestinal and pancreatic complications associated with severe pancreatitis. Arch Surg. 1995;135:817–823. Ho H, Frey CF. Gastrointestinal and pancreatic complications associated with severe pancreatitis. Arch Surg. 1995;135:817–823.
7.
go back to reference Tsiotos G, Smith CD, Sarr MG. Incidence and management of pancreatic and enteric fistula after surgical management of severe necrotizing pancreatitis. Arch Surg. 1995;130:48–52.PubMed Tsiotos G, Smith CD, Sarr MG. Incidence and management of pancreatic and enteric fistula after surgical management of severe necrotizing pancreatitis. Arch Surg. 1995;130:48–52.PubMed
9.
go back to reference Pederzoli P, Bassi C, Vesenticin S. Pancreatic Fistulas. Heidelberg: Springer; 1992. Pederzoli P, Bassi C, Vesenticin S. Pancreatic Fistulas. Heidelberg: Springer; 1992.
10.
go back to reference Halttunen J, Kylänpää L. Treatment of Pancreatic Fistulas. Eur J Trauma Emerg Surg. 2007;33:227–230.PubMed Halttunen J, Kylänpää L. Treatment of Pancreatic Fistulas. Eur J Trauma Emerg Surg. 2007;33:227–230.PubMed
11.
go back to reference Ali AE, Tan HL, Gent R, Davidson GP, Roberts-Thompson IC. Intrathoracic pancreatic pseudocyst: a rare complication of traumatic pancreatitis. Pediatr Surg Int. 2010;26:859–861.PubMed Ali AE, Tan HL, Gent R, Davidson GP, Roberts-Thompson IC. Intrathoracic pancreatic pseudocyst: a rare complication of traumatic pancreatitis. Pediatr Surg Int. 2010;26:859–861.PubMed
12.
go back to reference Tan MH, Kirk G, Archibold P, Kennedy P, Regn MC. Cardiac compromise due to pancreatic mediastinal pseudocyst. Eur J Gastroenterol Hepatol. 2002;14:1279–1282.PubMed Tan MH, Kirk G, Archibold P, Kennedy P, Regn MC. Cardiac compromise due to pancreatic mediastinal pseudocyst. Eur J Gastroenterol Hepatol. 2002;14:1279–1282.PubMed
13.
go back to reference Bhasin DK, Rana SS, Nanda M et al. Endoscopic management of pancreatic pseudocysts at atypical locations. Surg Endosc. 2010;24:1085–1091.PubMed Bhasin DK, Rana SS, Nanda M et al. Endoscopic management of pancreatic pseudocysts at atypical locations. Surg Endosc. 2010;24:1085–1091.PubMed
14.
go back to reference Wang GJ, Gao CF, Wei D, Wang C, Ding SQ. Acute pancreatitis: etiology and common pathogenesis. World J Gastroenterol. 2009;15:1427–1430.PubMedPubMedCentral Wang GJ, Gao CF, Wei D, Wang C, Ding SQ. Acute pancreatitis: etiology and common pathogenesis. World J Gastroenterol. 2009;15:1427–1430.PubMedPubMedCentral
15.
go back to reference Brock C, Nielsen LM, Lelic D, Drewes AM. Pathophysiology of chronic pancreatitis. World J Gastroenterol. 2013;19:7231–7240.PubMedPubMedCentral Brock C, Nielsen LM, Lelic D, Drewes AM. Pathophysiology of chronic pancreatitis. World J Gastroenterol. 2013;19:7231–7240.PubMedPubMedCentral
16.
go back to reference Klöppel G, Detlefsen S, Feyerabend B. Fibrosis of the pancreas: the initial tissue damage and the resulting pattern. Virchows Arch. 2004;445:1–8.PubMed Klöppel G, Detlefsen S, Feyerabend B. Fibrosis of the pancreas: the initial tissue damage and the resulting pattern. Virchows Arch. 2004;445:1–8.PubMed
17.
go back to reference Etemad B, Whitcomb DC. Chronic pancreatitis: diagnosis, classification, and new genetic developments. Gastroenterology. 2001;120:682–707.PubMed Etemad B, Whitcomb DC. Chronic pancreatitis: diagnosis, classification, and new genetic developments. Gastroenterology. 2001;120:682–707.PubMed
18.
go back to reference Banks PA, Bollen TL, Dervenis C et al. Classification of acute pancreatitis–2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62:102–111.PubMed Banks PA, Bollen TL, Dervenis C et al. Classification of acute pancreatitis–2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62:102–111.PubMed
19.
go back to reference Choudhury SR, Manoj M, Gupta P, Samanta J, Mandavdhare H, Kochhar R. Wall maturation in necrotic collections in acute pancreatitis: a computed tomography based evaluation. Acta Gastroenterol Belg. 2022;85:463–467.PubMed Choudhury SR, Manoj M, Gupta P, Samanta J, Mandavdhare H, Kochhar R. Wall maturation in necrotic collections in acute pancreatitis: a computed tomography based evaluation. Acta Gastroenterol Belg. 2022;85:463–467.PubMed
20.
go back to reference Kourtesis G, Wilson SE, Williams RA. The clinical significance of fluid collections in acute pancreatitis. Am Surg. 1990;56:796–799.PubMed Kourtesis G, Wilson SE, Williams RA. The clinical significance of fluid collections in acute pancreatitis. Am Surg. 1990;56:796–799.PubMed
21.
go back to reference Sagar S, Soundarajan R, Gupta P et al. Efficacy of endovascular embolization of arterial pseudoaneurysms in pancreatitis: A systematic review and meta-analysis. Pancreatology. 2021;21:46–58.PubMed Sagar S, Soundarajan R, Gupta P et al. Efficacy of endovascular embolization of arterial pseudoaneurysms in pancreatitis: A systematic review and meta-analysis. Pancreatology. 2021;21:46–58.PubMed
22.
go back to reference Murruste M, Kirsimägi Ü, Kase K, Veršinina T, Talving P, Lepner U. Complications of chronic pancreatitis prior to and following surgical treatment: A proposal for classification. World J Clin Cases. 2022;10:7808–7824.PubMedPubMedCentral Murruste M, Kirsimägi Ü, Kase K, Veršinina T, Talving P, Lepner U. Complications of chronic pancreatitis prior to and following surgical treatment: A proposal for classification. World J Clin Cases. 2022;10:7808–7824.PubMedPubMedCentral
23.
go back to reference Balthazar EJ, Freeny PC, vanSonnenberg E. Imaging and intervention in acute pancreatitis. Radiology. 1994;193:297–306.PubMed Balthazar EJ, Freeny PC, vanSonnenberg E. Imaging and intervention in acute pancreatitis. Radiology. 1994;193:297–306.PubMed
24.
go back to reference Johnson MD, Walsh RM, Henderson JM et al. Surgical versus nonsurgical management of pancreatic pseudocysts. J Clin Gastroenterol. 2009;43:586–590.PubMed Johnson MD, Walsh RM, Henderson JM et al. Surgical versus nonsurgical management of pancreatic pseudocysts. J Clin Gastroenterol. 2009;43:586–590.PubMed
25.
go back to reference Vosoghi M, Sial S, Garrett B et al. EUS-guided pancreatic pseudocyst drainage: review and experience at Harbor-UCLA Medical Center. Med Gen Med. 2002;4:2. Vosoghi M, Sial S, Garrett B et al. EUS-guided pancreatic pseudocyst drainage: review and experience at Harbor-UCLA Medical Center. Med Gen Med. 2002;4:2.
27.
go back to reference Martin M, Rossi RL, Munson JL, ReMine SG, Braasch JW. Management of pancreatic fistula. Arch Surg. 1989;124:571–573.PubMed Martin M, Rossi RL, Munson JL, ReMine SG, Braasch JW. Management of pancreatic fistula. Arch Surg. 1989;124:571–573.PubMed
28.
go back to reference Boerma D, Rauws EAJ, Gulik TM, Huibregtse K, Obertop H, Gouma DJ. Endoscopic stent placement for pancreaticocutaneous fistula after surgical drainage of the pancreas. Br J Surg. 2000;87:1506–1509.PubMed Boerma D, Rauws EAJ, Gulik TM, Huibregtse K, Obertop H, Gouma DJ. Endoscopic stent placement for pancreaticocutaneous fistula after surgical drainage of the pancreas. Br J Surg. 2000;87:1506–1509.PubMed
29.
go back to reference Fielding GA, McLatchie GR, Wilson C, Imrie CW, Carter DC. Acute pancreatitis and pancreatic fistula formation. Br J Surg. 1989;76:1126–1128.PubMed Fielding GA, McLatchie GR, Wilson C, Imrie CW, Carter DC. Acute pancreatitis and pancreatic fistula formation. Br J Surg. 1989;76:1126–1128.PubMed
30.
go back to reference Sikora SS, Khare R, Srikanth G, Kumar A, Saxena R, Kapoor VK. External pancreatic fistula as a sequel to management of acute severe necrotizing pancreatitis. Dig Surg. 2005;22:446–452.PubMed Sikora SS, Khare R, Srikanth G, Kumar A, Saxena R, Kapoor VK. External pancreatic fistula as a sequel to management of acute severe necrotizing pancreatitis. Dig Surg. 2005;22:446–452.PubMed
31.
go back to reference Faccioli N, Foti G, Molinari E et al. Role of fistulography in evaluating pancreatic fistula after pancreaticoduodenectomy. Br J Radiol. 2012;85:219–224.PubMedPubMedCentral Faccioli N, Foti G, Molinari E et al. Role of fistulography in evaluating pancreatic fistula after pancreaticoduodenectomy. Br J Radiol. 2012;85:219–224.PubMedPubMedCentral
32.
33.
go back to reference Ali T, Srinivasan N, Le V, Chimpiri AR, Tierney WM. Pancreaticopleural fistula. Pancreas. 2009;38:26–31. Ali T, Srinivasan N, Le V, Chimpiri AR, Tierney WM. Pancreaticopleural fistula. Pancreas. 2009;38:26–31.
34.
go back to reference Galluzzo A, Iannicelli E, Marignani M, DelleFave G, David V. A pancreatico-pleural fistula diagnosed with magnetic resonance cholangiopancreatography. JOP. 2008;9:654–657.PubMed Galluzzo A, Iannicelli E, Marignani M, DelleFave G, David V. A pancreatico-pleural fistula diagnosed with magnetic resonance cholangiopancreatography. JOP. 2008;9:654–657.PubMed
35.
go back to reference Morgan KA, Adams DB. Management of internal and external pancreatic fistulas. Surg Clin North Am. 2007;87:1503–1513.PubMed Morgan KA, Adams DB. Management of internal and external pancreatic fistulas. Surg Clin North Am. 2007;87:1503–1513.PubMed
36.
go back to reference Sundaram S, Patra BR, Choksi D et al. Outcomes and predictors of response to endotherapy in pancreatic ductal disruptions with refractory internal and high-output external fistulae. Ann Hepatobiliary Pancreat Surg. 2022;26:347–354.PubMedPubMedCentral Sundaram S, Patra BR, Choksi D et al. Outcomes and predictors of response to endotherapy in pancreatic ductal disruptions with refractory internal and high-output external fistulae. Ann Hepatobiliary Pancreat Surg. 2022;26:347–354.PubMedPubMedCentral
37.
go back to reference Sherman S, Lehman GA. Endoscopic pancreatic sphincterotomy: techniques and complications. Gastroint Endosc Clin N Am. 1998;8:115–124. Sherman S, Lehman GA. Endoscopic pancreatic sphincterotomy: techniques and complications. Gastroint Endosc Clin N Am. 1998;8:115–124.
38.
go back to reference Hung ML, Ma S, Shlansky-Goldberg RD. Outcomes after Transgastric Drainage of Pancreatic Duct Leaks. J Vasc Interv Radiol. 2023;34:277–283.PubMed Hung ML, Ma S, Shlansky-Goldberg RD. Outcomes after Transgastric Drainage of Pancreatic Duct Leaks. J Vasc Interv Radiol. 2023;34:277–283.PubMed
39.
go back to reference Pouchen T, Bony RM, Hedelius F et al. Endoscopic stenting for relief of pain in chronic pancreatitis: results of a standardized protocol. Gastroint Endosc. 1995;42:452–456. Pouchen T, Bony RM, Hedelius F et al. Endoscopic stenting for relief of pain in chronic pancreatitis: results of a standardized protocol. Gastroint Endosc. 1995;42:452–456.
40.
go back to reference Halttunen J, Weckman L, Kemppainen E, Kylänpää ML. The endoscopic management of pancreatic fistulas. Surg Endosc 2005;19:559–562.PubMed Halttunen J, Weckman L, Kemppainen E, Kylänpää ML. The endoscopic management of pancreatic fistulas. Surg Endosc 2005;19:559–562.PubMed
41.
go back to reference Ashby K, Lo SK. The role of pancreatic stenting in obstructive ductal disorders other than pancreas divisum. Gastrointest Endosc. 1995;42:306–311.PubMed Ashby K, Lo SK. The role of pancreatic stenting in obstructive ductal disorders other than pancreas divisum. Gastrointest Endosc. 1995;42:306–311.PubMed
42.
go back to reference Findeiss LK, Brandabur J, Traverso LW, Robinson DH. Percutaneous embolization of the pancreatic duct with cyanoacrylate tissue adhesive in disconnected duct syndrome. J Vasc Interv Radiol. 2003 Jan;14:107–11. doi: Findeiss LK, Brandabur J, Traverso LW, Robinson DH. Percutaneous embolization of the pancreatic duct with cyanoacrylate tissue adhesive in disconnected duct syndrome. J Vasc Interv Radiol. 2003 Jan;14:107–11. doi:
43.
go back to reference Hirota M, Kamekawa K, Tashima T, Mizumoto M, Ohara C, Beppu T, Shimada S, Yamaguchi Y, Ogawa M. Percutaneous embolization of the distal pancreatic duct to treat intractable pancreatic juice fistula. Pancreas. 2001;22:214–216.PubMed Hirota M, Kamekawa K, Tashima T, Mizumoto M, Ohara C, Beppu T, Shimada S, Yamaguchi Y, Ogawa M. Percutaneous embolization of the distal pancreatic duct to treat intractable pancreatic juice fistula. Pancreas. 2001;22:214–216.PubMed
44.
go back to reference Cothren CC, McIntyre RC Jr, Johnson S, Stiegmann GV. Management of low-output pancreatic fistulas with fibrin glue. Am J Surg. 2004;188:89–91.PubMed Cothren CC, McIntyre RC Jr, Johnson S, Stiegmann GV. Management of low-output pancreatic fistulas with fibrin glue. Am J Surg. 2004;188:89–91.PubMed
45.
go back to reference Ridgeway MG, Stabile BE. Surgical management and treatment of pancreatic fistula. Surg Clin N Am 1996;76:1159–1173.PubMed Ridgeway MG, Stabile BE. Surgical management and treatment of pancreatic fistula. Surg Clin N Am 1996;76:1159–1173.PubMed
46.
go back to reference Kohler E, Beglinger C, Dettwiler S et al. Effect of a new somatostatin analogue on pancreatic function in healthy volunteers. Pancreas 1986;1:154–159.PubMed Kohler E, Beglinger C, Dettwiler S et al. Effect of a new somatostatin analogue on pancreatic function in healthy volunteers. Pancreas 1986;1:154–159.PubMed
47.
go back to reference Prinz RA, Pickelman J, Hoffman JP. Treatment of pancreatic cutaneous fistula with a stomatostatin analog. Am J Surg. 1988;155:37–42. Prinz RA, Pickelman J, Hoffman JP. Treatment of pancreatic cutaneous fistula with a stomatostatin analog. Am J Surg. 1988;155:37–42.
48.
go back to reference Ahren B, Tranberg S. Treatment of pancreatic fistula with somatostatin analogue. Br J Surg. 1988;75:716–718. Ahren B, Tranberg S. Treatment of pancreatic fistula with somatostatin analogue. Br J Surg. 1988;75:716–718.
49.
go back to reference Gans SL, van Westreenen HL, Kiewiet JJ, Rauws EA, Gouma DJ, Boermeester MA. Systematic review and meta-analysis of somatostatin analogues for the treatment of pancreatic fistula. Br J Surg. 2012;99:754–760.PubMed Gans SL, van Westreenen HL, Kiewiet JJ, Rauws EA, Gouma DJ, Boermeester MA. Systematic review and meta-analysis of somatostatin analogues for the treatment of pancreatic fistula. Br J Surg. 2012;99:754–760.PubMed
50.
go back to reference Maatman TK, Roch AM, Lewellen KA et al. Disconnected Pancreatic Duct Syndrome: Spectrum of Operative Management. J Surg Res. 2020;247:297–303.PubMed Maatman TK, Roch AM, Lewellen KA et al. Disconnected Pancreatic Duct Syndrome: Spectrum of Operative Management. J Surg Res. 2020;247:297–303.PubMed
51.
go back to reference Nealon WH, Bhutani M, Riall TS et al. A unifying concept: pancreatic ductal anatomy both predicts and determines the major complications resulting from pancreatitis. J Am Coll Surg. 2009;208:790–799.PubMed Nealon WH, Bhutani M, Riall TS et al. A unifying concept: pancreatic ductal anatomy both predicts and determines the major complications resulting from pancreatitis. J Am Coll Surg. 2009;208:790–799.PubMed
52.
go back to reference Timmerhuis HC, van Dijk SM, Verdonk RC et al. Various modalities accurate in diagnosing a disrupted or disconnected pancreatic duct in acute pancreatitis: a systematic review. Dig Dis Sci. 2021;66:1415–1424.PubMed Timmerhuis HC, van Dijk SM, Verdonk RC et al. Various modalities accurate in diagnosing a disrupted or disconnected pancreatic duct in acute pancreatitis: a systematic review. Dig Dis Sci. 2021;66:1415–1424.PubMed
53.
go back to reference Miller FH, Keppke AL, Dalal K, Ly JN, Kamler VA, Sica GT. MRI of pancreatitis and its complications: part 1, acute pancreatitis. AJR Am J Roentgenol. 2004;183:1637e44. Miller FH, Keppke AL, Dalal K, Ly JN, Kamler VA, Sica GT. MRI of pancreatitis and its complications: part 1, acute pancreatitis. AJR Am J Roentgenol. 2004;183:1637e44.
54.
go back to reference Akisik MF, Sandrasegaran K, Aisen AA, Maglinte DD, Sherman S, Lehman GA. Dynamic secretin-enhanced MR cholangiopancreatography. Radiographics. 2006;26:665e77. Akisik MF, Sandrasegaran K, Aisen AA, Maglinte DD, Sherman S, Lehman GA. Dynamic secretin-enhanced MR cholangiopancreatography. Radiographics. 2006;26:665e77.
55.
go back to reference Sandrasegaran K, Tann M, Jennings SG et al. Disconnection of the pancreatic duct: an important but overlooked complication of severe acute pancreatitis. Radiographics. 2007;27:1389–1400.PubMed Sandrasegaran K, Tann M, Jennings SG et al. Disconnection of the pancreatic duct: an important but overlooked complication of severe acute pancreatitis. Radiographics. 2007;27:1389–1400.PubMed
56.
go back to reference Verma S, Rana SS. Disconnected pancreatic duct syndrome: update review on clinical implications and management. Pancreatology. 2020;20:1035–1044.PubMed Verma S, Rana SS. Disconnected pancreatic duct syndrome: update review on clinical implications and management. Pancreatology. 2020;20:1035–1044.PubMed
57.
go back to reference Dijk SM, Timmerhuis HC, Verdonk RC et al. Treatment of disrupted and disconnected pancreatic duct in necrotizing pancreatitis: a systematic review and meta-analysis. Pancreatology. 2019;19:905–915.PubMed Dijk SM, Timmerhuis HC, Verdonk RC et al. Treatment of disrupted and disconnected pancreatic duct in necrotizing pancreatitis: a systematic review and meta-analysis. Pancreatology. 2019;19:905–915.PubMed
58.
go back to reference Varadarajulu S, Rana SS, Bhasin DK. Endoscopic therapy for pancreatic duct leaks and disruptions. Gastrointest Endosc Clin N Am. 2013;23:863–892.PubMed Varadarajulu S, Rana SS, Bhasin DK. Endoscopic therapy for pancreatic duct leaks and disruptions. Gastrointest Endosc Clin N Am. 2013;23:863–892.PubMed
59.
go back to reference Fischer TD, Gutman DS, Hughes SJ, Trevino JG, Behrns KE. Disconnected pancreatic duct syndrome: disease classification and management strategies. J Am Coll Surg. 2014;219:704–712.PubMed Fischer TD, Gutman DS, Hughes SJ, Trevino JG, Behrns KE. Disconnected pancreatic duct syndrome: disease classification and management strategies. J Am Coll Surg. 2014;219:704–712.PubMed
60.
go back to reference Bakker OJ, van Santvoort HC, van Brunschot S et al. Endoscopic transgastric vs surgical necrosectomy for infected necrotizing pancreatitis: a randomized trial. J Am Med Assoc. 2012;307:1053–1061. Bakker OJ, van Santvoort HC, van Brunschot S et al. Endoscopic transgastric vs surgical necrosectomy for infected necrotizing pancreatitis: a randomized trial. J Am Med Assoc. 2012;307:1053–1061.
61.
go back to reference Khan MA, Kahaleh M, Khan Z et al. Time for a changing of guard: from minimally invasive surgery to endoscopic drainage for management of pancreatic walled-off necrosis. J Clin Gastroenterol. 2019;53:81–88.PubMed Khan MA, Kahaleh M, Khan Z et al. Time for a changing of guard: from minimally invasive surgery to endoscopic drainage for management of pancreatic walled-off necrosis. J Clin Gastroenterol. 2019;53:81–88.PubMed
62.
go back to reference van Brunschot S, van Grinsven J, van Santvoort HC et al. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial. Lancet. 2018;391:51–58.PubMed van Brunschot S, van Grinsven J, van Santvoort HC et al. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial. Lancet. 2018;391:51–58.PubMed
63.
go back to reference Gliedman ML, Bolooki H, Rosen RG. Acute pancreatitis. Curr Probl Surg. 1970;7:1–52. Gliedman ML, Bolooki H, Rosen RG. Acute pancreatitis. Curr Probl Surg. 1970;7:1–52.
64.
go back to reference Kumar P, Gupta P, Rana S. Thoracic complications of pancreatitis. JGH Open. 2019;3:71–79.PubMed Kumar P, Gupta P, Rana S. Thoracic complications of pancreatitis. JGH Open. 2019;3:71–79.PubMed
65.
go back to reference Khan MS, Najmi S, Zia MA, Hamza M, Iqbal H, Awab A. Pancreaticopericardial fistula: A case report and literature review. Case Rep Crit Care. 2016;2016:7169341.PubMedPubMedCentral Khan MS, Najmi S, Zia MA, Hamza M, Iqbal H, Awab A. Pancreaticopericardial fistula: A case report and literature review. Case Rep Crit Care. 2016;2016:7169341.PubMedPubMedCentral
66.
67.
go back to reference Jiang W, Tong Z, Yang D et al. Gastrointestinal Fistulas in Acute Pancreatitis With Infected Pancreatic or Peripancreatic Necrosis: A 4-Year Single-Center Experience. Medicine (Baltimore). 2016;95:e3318.PubMedPubMedCentral Jiang W, Tong Z, Yang D et al. Gastrointestinal Fistulas in Acute Pancreatitis With Infected Pancreatic or Peripancreatic Necrosis: A 4-Year Single-Center Experience. Medicine (Baltimore). 2016;95:e3318.PubMedPubMedCentral
68.
go back to reference Chen Y, Jiang Y, Qian W et al. Endoscopic transpapillary drainage in disconnected pancreatic duct syndrome after acute pancreatitis and trauma: long-term outcomes in 31 patients. BMC Gastroenterol. 2019;19:54.PubMedPubMedCentral Chen Y, Jiang Y, Qian W et al. Endoscopic transpapillary drainage in disconnected pancreatic duct syndrome after acute pancreatitis and trauma: long-term outcomes in 31 patients. BMC Gastroenterol. 2019;19:54.PubMedPubMedCentral
69.
go back to reference Bansal A, Gupta P, Singh H et al. Gastrointestinal complications in acute and chronic pancreatitis. JGH Open. 2019;3:450–455.PubMedPubMedCentral Bansal A, Gupta P, Singh H et al. Gastrointestinal complications in acute and chronic pancreatitis. JGH Open. 2019;3:450–455.PubMedPubMedCentral
70.
go back to reference Bhandari R, Chamlagain R, Bhattarai S, Tischler EH, Mandal R, Bhandari RS. Pancreatic ascites managed with a conservative approach: a case report. J Med Case Rep. 2020;14:154.PubMedPubMedCentral Bhandari R, Chamlagain R, Bhattarai S, Tischler EH, Mandal R, Bhandari RS. Pancreatic ascites managed with a conservative approach: a case report. J Med Case Rep. 2020;14:154.PubMedPubMedCentral
71.
go back to reference Lakhtakia S, Reddy DN. Pancreatic leaks: endo-therapy first? J Gastroenterol Hepatol. 2009;24:1158–1160.PubMed Lakhtakia S, Reddy DN. Pancreatic leaks: endo-therapy first? J Gastroenterol Hepatol. 2009;24:1158–1160.PubMed
72.
go back to reference Goenka MK, Jha AK, Kapoor N, Goenka U. Glue for sealing internal pancreatic fistula in a patient with liver cirrhosis: a useful technique. JOP. 2012;13:292–295.PubMed Goenka MK, Jha AK, Kapoor N, Goenka U. Glue for sealing internal pancreatic fistula in a patient with liver cirrhosis: a useful technique. JOP. 2012;13:292–295.PubMed
73.
go back to reference Seewald S, Brand B, Groth S et al. Endoscopic sealing of pancreatic fistula by using N-butyl-2-cyanoacrylate. Gastrointest Endosc. 2004;59:463–470.PubMed Seewald S, Brand B, Groth S et al. Endoscopic sealing of pancreatic fistula by using N-butyl-2-cyanoacrylate. Gastrointest Endosc. 2004;59:463–470.PubMed
74.
go back to reference Ranson JHC, Roses DF, Fink SD. Early respiratory insufficiency in acute pancreatitis. Ann Surg. 1973;178:9. Ranson JHC, Roses DF, Fink SD. Early respiratory insufficiency in acute pancreatitis. Ann Surg. 1973;178:9.
75.
go back to reference King JC, Reber HA, Shiraga S, Hines OJ. Pancreatic-pleural fistula is best managed by early operative intervention. Surgery. 2010;147:154–159.PubMed King JC, Reber HA, Shiraga S, Hines OJ. Pancreatic-pleural fistula is best managed by early operative intervention. Surgery. 2010;147:154–159.PubMed
76.
go back to reference Tay CM, Chang SK. Diagnosis and management of pancreaticopleural fistula. Singapore Med J. 2013;54:190–194.PubMed Tay CM, Chang SK. Diagnosis and management of pancreaticopleural fistula. Singapore Med J. 2013;54:190–194.PubMed
77.
go back to reference Vyas S, Gogoi D, Sinha SK, Singh P, Yadav TD, Khandelwal N. Pancreaticopleural fistula: an unusual complication of pancreatitis diagnosed with magnetic resonance cholangiopancreatography. JOP. 2009;10:671–673.PubMed Vyas S, Gogoi D, Sinha SK, Singh P, Yadav TD, Khandelwal N. Pancreaticopleural fistula: an unusual complication of pancreatitis diagnosed with magnetic resonance cholangiopancreatography. JOP. 2009;10:671–673.PubMed
78.
go back to reference Oh YS, Edmundowicz SA, Jonnalagadda SS, Azar RR. Pancreaticopleural fistula: report of two cases and review of the literature. Dig Dis Sci. 2006;51:1–6.PubMed Oh YS, Edmundowicz SA, Jonnalagadda SS, Azar RR. Pancreaticopleural fistula: report of two cases and review of the literature. Dig Dis Sci. 2006;51:1–6.PubMed
79.
go back to reference Schweigert M, Solymosi N, Dubecz A, Ofner D, Stein HJ. Length of nonoperative treatment and risk of pleural empyema in the management of pancreatitis-induced pancreaticopleural fistula. Am Surg. 2013;79:614–619.PubMed Schweigert M, Solymosi N, Dubecz A, Ofner D, Stein HJ. Length of nonoperative treatment and risk of pleural empyema in the management of pancreatitis-induced pancreaticopleural fistula. Am Surg. 2013;79:614–619.PubMed
80.
go back to reference Rockey DC, Cello JP. Pancreaticopleural fistula. Report of 7 patients and review of the literature. Medicine. 1990; 69: 332–44. Rockey DC, Cello JP. Pancreaticopleural fistula. Report of 7 patients and review of the literature. Medicine. 1990; 69: 332–44.
81.
go back to reference Dhebri AR, Ferran N. Nonsurgical management of pancreaticopleural fistula. JOP. 2005;6:152–161.PubMed Dhebri AR, Ferran N. Nonsurgical management of pancreaticopleural fistula. JOP. 2005;6:152–161.PubMed
82.
go back to reference Bhasin DK, Rana SS. Endoscopic therapy as a first-line therapy for pancreatic-pleural fistula. Surgery. 2010;148:609–610.PubMed Bhasin DK, Rana SS. Endoscopic therapy as a first-line therapy for pancreatic-pleural fistula. Surgery. 2010;148:609–610.PubMed
83.
go back to reference Bhasin DK, Rana SS, Siyad I et al. Endoscopic transpapillary nasopancreatic drainage alone to treat pancreatic ascites and pleural effusion. J Gastroenterol Hepatol. 2006;21:1059–1066.PubMed Bhasin DK, Rana SS, Siyad I et al. Endoscopic transpapillary nasopancreatic drainage alone to treat pancreatic ascites and pleural effusion. J Gastroenterol Hepatol. 2006;21:1059–1066.PubMed
84.
go back to reference Kim D, Chung H, Gham C et al. A case of complete resolution of mediastinal pseudocyst and pleural effusion by endoscopic stenting of pancreatic duct. Yonsei Med J 2003;44:727–731.PubMed Kim D, Chung H, Gham C et al. A case of complete resolution of mediastinal pseudocyst and pleural effusion by endoscopic stenting of pancreatic duct. Yonsei Med J 2003;44:727–731.PubMed
85.
go back to reference Xu H, Zhang X, Christe A et al. Anatomic pathways of peripancreatic fluid draining to mediastinum in recurrent acute pancreatitis: visible human project and CT study. PLoS One. 2013;8:62025. Xu H, Zhang X, Christe A et al. Anatomic pathways of peripancreatic fluid draining to mediastinum in recurrent acute pancreatitis: visible human project and CT study. PLoS One. 2013;8:62025.
86.
go back to reference Rana SS, Bhasin DK, Nanda M et al. Endoscopic transpapillary drainage for external fistulas developing after surgical or radiological pancreatic interventions. J Gastroenterol Hepatol. 2010;25:1087–1092.PubMed Rana SS, Bhasin DK, Nanda M et al. Endoscopic transpapillary drainage for external fistulas developing after surgical or radiological pancreatic interventions. J Gastroenterol Hepatol. 2010;25:1087–1092.PubMed
87.
go back to reference Pai CG, Suvarna D, Bhat G. Endoscopic treatment as first-line therapy for pancreatic ascites and pleural effusion. J Gastroenterol Hepatol. 2009; 24: 1198–202.4. Pai CG, Suvarna D, Bhat G. Endoscopic treatment as first-line therapy for pancreatic ascites and pleural effusion. J Gastroenterol Hepatol. 2009; 24: 1198–202.4.
88.
go back to reference Cesare ED, Sibio AD, Gennarelli A, et al. An unusual case of ascending pancreatitis with mediastinal involvement: a case report with CT and MRI findings. Case Rep Radiol. 2014: 925105. Cesare ED, Sibio AD, Gennarelli A, et al. An unusual case of ascending pancreatitis with mediastinal involvement: a case report with CT and MRI findings. Case Rep Radiol. 2014: 925105.
89.
go back to reference Kawashima A, Fishman EK, Kuhlman JE, Nixon MS. CT of posterior mediastinal masses. Radiographics. 1991;11:1045–1067.PubMed Kawashima A, Fishman EK, Kuhlman JE, Nixon MS. CT of posterior mediastinal masses. Radiographics. 1991;11:1045–1067.PubMed
90.
go back to reference Bhasin DK, Rana SS, Rao C et al. Clinical presentation, radiological features, and endoscopic management of mediastinal pseudocysts: experience of a decade. Gastrointest Endosc. 2012;76:1056–1060.PubMed Bhasin DK, Rana SS, Rao C et al. Clinical presentation, radiological features, and endoscopic management of mediastinal pseudocysts: experience of a decade. Gastrointest Endosc. 2012;76:1056–1060.PubMed
91.
go back to reference Rana SS, Sharma V, Sharma R, Chhabra P, Gupta R, Bhasin DK. Nonfluoroscopic endoscopic ultrasound guided transmural drainage of pancreatic pseudocyst at atypical locations. J Dig Endosc. 2016;7:137–143. Rana SS, Sharma V, Sharma R, Chhabra P, Gupta R, Bhasin DK. Nonfluoroscopic endoscopic ultrasound guided transmural drainage of pancreatic pseudocyst at atypical locations. J Dig Endosc. 2016;7:137–143.
92.
go back to reference Bhasin DK, Rana SS, Chandail VS, Nanda M, Sinha SK, Nagi B. Successful resolution of a mediastinal pseudocyst and pancreatic pleural effusion by endoscopic nasopancreatic drainage. JOP. 2005;6:359–364.PubMed Bhasin DK, Rana SS, Chandail VS, Nanda M, Sinha SK, Nagi B. Successful resolution of a mediastinal pseudocyst and pancreatic pleural effusion by endoscopic nasopancreatic drainage. JOP. 2005;6:359–364.PubMed
93.
go back to reference Rana SS, Bhasin DK, Rao C, Singh H, Sharma V, Singh K. Esophageal stricture following successful resolution of a mediastinal pseudocyst by endoscopic transpapillary drainage. Endoscopy. 2012;44 Suppl 2 UCTN:E121-E122. Rana SS, Bhasin DK, Rao C, Singh H, Sharma V, Singh K. Esophageal stricture following successful resolution of a mediastinal pseudocyst by endoscopic transpapillary drainage. Endoscopy. 2012;44 Suppl 2 UCTN:E121-E122.
94.
go back to reference Rana SS, Bhasin DK. Endoscopic management of pancreatic fluid collections. J Dig Endosc. 2012;3:40–43. Rana SS, Bhasin DK. Endoscopic management of pancreatic fluid collections. J Dig Endosc. 2012;3:40–43.
95.
go back to reference Metaxa D, Balakrishnan A, Upponi S, Huguet EL, Praseedom RK. Surgical intervention for mediastinal pancreatic pseudocysts. A case series and review of the literature. JOP. 2015; 16: 74–7. Metaxa D, Balakrishnan A, Upponi S, Huguet EL, Praseedom RK. Surgical intervention for mediastinal pancreatic pseudocysts. A case series and review of the literature. JOP. 2015; 16: 74–7.
96.
go back to reference Urakami A, Tsunoda T, Hayashi J, Okaya Y, Mizuno M. Spontaneous fistulization of a pancreatic pseudocyst into the colon and duodenum. Gastrointest Endosc. 2002;55:949–951.PubMed Urakami A, Tsunoda T, Hayashi J, Okaya Y, Mizuno M. Spontaneous fistulization of a pancreatic pseudocyst into the colon and duodenum. Gastrointest Endosc. 2002;55:949–951.PubMed
97.
go back to reference Hua Z, Su Y, Huang X et al. Analysis of risk factors related to gastrointestinal fistula in patients with severe acute pancreatitis: a retrospective study of 344 cases in a single Chinese center. BMC Gastroenterol. 2017;17:29.PubMedPubMedCentral Hua Z, Su Y, Huang X et al. Analysis of risk factors related to gastrointestinal fistula in patients with severe acute pancreatitis: a retrospective study of 344 cases in a single Chinese center. BMC Gastroenterol. 2017;17:29.PubMedPubMedCentral
98.
go back to reference Kochhar R, Jain K, Gupta V et al. Fistulization in the GI tract in acute pancreatitis. Gastrointest Endosc. 2012;75:436–440.PubMed Kochhar R, Jain K, Gupta V et al. Fistulization in the GI tract in acute pancreatitis. Gastrointest Endosc. 2012;75:436–440.PubMed
99.
go back to reference Falconi M, Pederzoli P. The relevance of gastrointestinal fistulae in clinical practice: a review. Gut. 2001; 49: iv2–10 Falconi M, Pederzoli P. The relevance of gastrointestinal fistulae in clinical practice: a review. Gut. 2001; 49: iv2–10
100.
go back to reference Gupta P, Chayan Das G, Sharma V et al. Role of computed tomography in prediction of gastrointestinal fistula in patients with acute pancreatitis. Acta Gastroenterol Belg. 2019;82:495–500.PubMed Gupta P, Chayan Das G, Sharma V et al. Role of computed tomography in prediction of gastrointestinal fistula in patients with acute pancreatitis. Acta Gastroenterol Belg. 2019;82:495–500.PubMed
101.
go back to reference Mohamed SR, Siriwardena AK. Understanding the colonic complications of pancreatitis. Pancreatology. 2008;8:153–158.PubMed Mohamed SR, Siriwardena AK. Understanding the colonic complications of pancreatitis. Pancreatology. 2008;8:153–158.PubMed
102.
go back to reference Bhurwal A, Mutneja H, Tawadross A, Pioppo L, Brahmbhatt B. Gastrointestinal fistula endoscopic closure techniques. Annals Gastroenterol. 2020;33:554. Bhurwal A, Mutneja H, Tawadross A, Pioppo L, Brahmbhatt B. Gastrointestinal fistula endoscopic closure techniques. Annals Gastroenterol. 2020;33:554.
103.
go back to reference Cameron JL. Chronic pancreatic ascites and pancreatic pleural effusions. Gastroenterology. 1978;74:134–140.PubMed Cameron JL. Chronic pancreatic ascites and pancreatic pleural effusions. Gastroenterology. 1978;74:134–140.PubMed
104.
go back to reference Sankaron S, Walt AJ. Pancreatic ascites. Arch Surg. 1976;3:430–434. Sankaron S, Walt AJ. Pancreatic ascites. Arch Surg. 1976;3:430–434.
105.
go back to reference Donowitz M, Kerstein MD, Spiro HM. Pancreatic ascites. Medicine. 1974;53:183–195.PubMed Donowitz M, Kerstein MD, Spiro HM. Pancreatic ascites. Medicine. 1974;53:183–195.PubMed
106.
go back to reference Weaver DW, Walt AJ, Sugawa C, Bouwman DL. A continuing appraisal of pancreatic ascites. Surg Gynecol Obstet. 10982; 154:845–848. Weaver DW, Walt AJ, Sugawa C, Bouwman DL. A continuing appraisal of pancreatic ascites. Surg Gynecol Obstet. 10982; 154:845–848.
107.
go back to reference Sankaron S, Sugawa C, Walt AJ. Value of endoscopic retrograde pancreatography in pancreatic ascites. Surg Gynecol Obstet. 148:185 192, 1979 Sankaron S, Sugawa C, Walt AJ. Value of endoscopic retrograde pancreatography in pancreatic ascites. Surg Gynecol Obstet. 148:185 192, 1979
108.
go back to reference Nayak SK, Gaadhe RL, Piramanayagam P, Palaniswamy KR. A young man with skin rash and ascites. Trop Doct. 2015;46:60–61.PubMed Nayak SK, Gaadhe RL, Piramanayagam P, Palaniswamy KR. A young man with skin rash and ascites. Trop Doct. 2015;46:60–61.PubMed
109.
Metadata
Title
Imaging Diagnosis and Management of Fistulas in Pancreatitis
Authors
Manika Chhabra
Pankaj Gupta
Jimil Shah
Jayanta Samanta
Harshal Mandavdhare
Vishal Sharma
Saroj K. Sinha
Usha Dutta
Rakesh Kochhar
Publication date
19-12-2023

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