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Seminars in Immunopathology
Published in: Seminars in Immunopathology 4/2016

01-07-2016 | Review

Macrophage-epithelial interactions in pulmonary alveoli

Authors: Jahar Bhattacharya, Kristin Westphalen

Published in: Seminars in Immunopathology | Issue 4/2016

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Abstract

Alveolar macrophages have been investigated for years by approaches involving macrophage extraction from the lung by bronchoalveolar lavage, or by cell removal from lung tissue. Since extracted macrophages are studied outside their natural milieu, there is little understanding of the extent to which alveolar macrophages interact with the epithelium, or with one another to generate the lung’s innate immune response to pathogen challenge. Here, we review new evidence of macrophage-epithelial interactions in the lung, and we address the emerging understanding that the alveolar epithelium plays an important role in orchestrating the macrophage-driven immune response.
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Metadata
Title
Macrophage-epithelial interactions in pulmonary alveoli
Authors
Jahar Bhattacharya
Kristin Westphalen
Publication date
01-07-2016
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 4/2016
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-016-0569-x

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