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Published in:

01-09-2009 | Review Paper

Macro Role(s) of MicroRNAs in Fragile X Syndrome?

Authors: Xuekun Li, Peng Jin

Published in: NeuroMolecular Medicine | Issue 3/2009

Abstract

Fragile X syndrome (FXS), the most common form of inherited mental retardation, is caused by the loss of functional fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein that can regulate the translation of specific mRNAs. It is known to regulate synaptic development through the regulation of local protein synthesis in synapses. MicroRNAs (miRNAs) are a class of small noncoding RNAs involved in almost every biological process. They exhibit spatiotemporal expression during brain development, and some miRNAs play important roles in neural development. A growing body of evidence now implicates the miRNA pathway in the molecular pathogenesis of FXS. Here we review the current state of knowledge about the microRNA pathway in neural development and the emergence of possible roles for miRNAs in FXS.

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Title: Macro Role(s) of MicroRNAs in Fragile X Syndrome?
Authors: Xuekun Li
Peng Jin
Publication date: 01-09-2009
Publisher: Humana Press Inc
Published in: NeuroMolecular Medicine / Issue 3/2009
Print ISSN: 1535-1084
Electronic ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-009-8081-2

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Macro Role(s) of MicroRNAs in Fragile X Syndrome?

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