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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 4/2024

Open Access 04-01-2024 | Lymphopenia | ASO Author Reflections

ASO Author Reflections: Perioperative Lymphopenia Following Hepatectomy for Hepatocellular Carcinoma: A Routine Yet Overlooked Prognostic Biomarker

Authors: Diamantis I. Tsilimigras, MD, Timothy M. Pawlik, MD, PhD, MPH, MTS, MBA

Published in: Annals of Surgical Oncology | Issue 4/2024

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Excerpt

Immune dysregulation plays an important role in cancer progression.1,2 Lymphopenia, defined as the absence or reduced count of host lymphocytes, in the perioperative period might indicate a state of pre-existing cancer-related immune tolerance.3,4 Although laboratory tests are routinely obtained prior to and following a hepatectomy for hepatocellular carcinoma (HCC), little is known about the incidence and clinical significance of perioperative lymphopenia among patients undergoing resection for HCC. In this study, we sought to investigate whether preoperative or surgical stress-induced lymphopenia (i.e. absolute lymphocyte count [ALC] <1000/μL) was predictive of short- and long-term outcomes following HCC resection.5 …
Literature
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2.
3.
Ceze N, Thibault G, Goujon G, et al. Pre-treatment lymphopenia as a prognostic biomarker in colorectal cancer patients receiving chemotherapy. Cancer Chemother Pharmacol. 2011;68(5):1305–13.CrossRefPubMed
4.
De Giorgi U, Mego M, Scarpi E, et al. Relationship between lymphocytopenia and circulating tumor cells as prognostic factors for overall survival in metastatic breast cancer. Clin Breast Cancer. 2012;12(4):264–9.CrossRefPubMed
5.
Metadata
Title
ASO Author Reflections: Perioperative Lymphopenia Following Hepatectomy for Hepatocellular Carcinoma: A Routine Yet Overlooked Prognostic Biomarker
Authors
Diamantis I. Tsilimigras, MD
Timothy M. Pawlik, MD, PhD, MPH, MTS, MBA
Publication date
04-01-2024
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 4/2024
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-023-14856-8

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