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Open Access 01-12-2021 | Lymphoma | Case report

Successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in patients with diffuse large B-cell lymphoma: a case report

Authors: Machiko Umemura, Goki Suda, Shihori Tsukamoto, Ko Ebata, Shinjiro Takahash, Takashi Sasaki, Sae Nakajima, Koji Hirata, Mariko Ozasa, Masatoshi Takano, Masaki Katagiri, Naoya Sakamoto

Published in: BMC Infectious Diseases | Issue 1/2021

Abstract

Background

In patients with hepatitis C virus (HCV) and malignant lymphoma, hepatitis C flare during R-CHOP can result in discontinuation of treatment. However, appropriate therapeutic strategies for managing hepatitis C flare during R-CHOP have not been established, and this issue is complicated by conflicting results regarding the use of direct-acting antivirals in patients with uncontrolled malignancies.

Case presentation

We report the first case of effective and safe treatment with on-demand 8-week glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in a patient with diffuse large B-cell lymphoma (DLBCL). The patient completed five additional courses of R-CHOP without hepatic toxicity. A complete response of DLBCL and a sustained virological response were observed at 24 weeks after glecaprevir and pibrentasvir completion.

Conclusion

On-demand, direct-acting antivirals could be a novel strategy for managing hepatitis C flare during R-CHOP.

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Title: Successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in patients with diffuse large B-cell lymphoma: a case report
Authors: Machiko Umemura
Goki Suda
Shihori Tsukamoto
Ko Ebata
Shinjiro Takahash
Takashi Sasaki
Sae Nakajima
Koji Hirata
Mariko Ozasa
Masatoshi Takano
Masaki Katagiri
Naoya Sakamoto
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Lymphoma
Hepatitis C
Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma
Published in: BMC Infectious Diseases / Issue 1/2021
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/s12879-021-06091-x

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Abstract

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