A 75-year-old man presented with a 4-day history of intermittent abdominal pain and distention. He had no significant past medical history. Blood routine examination revealed a white cell count of 3730 per cubic millimeter (reference range, 4000 to 10,000) and a hemoglobin of 117 g per cubic decimeter (reference range, 120 to 160). The levels of his carcinoembryonic antigen (CEA) and cancer antigen 19-9 (CA19-9) showed normal. Computed tomography showed ileo-colic intussusception caused by a mass in the terminal ileum (Fig. 1a). Colonoscopy showed a tumor which came from intussuscepted ileum (Fig. 1b). During surgery, we found the tumor was located at distal part of his ileum (Fig. 2a). We performed a resection of the tumor and part of the ileum for him. Pathological test indicated a B cell non-Hodgkin’s lymphoma (Fig. 2b).