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Angiogenesis
Published in: Angiogenesis 1/2020

01-02-2020 | Lung Cancer | Review Paper

Vascular co-option in brain metastasis

Authors: Pedro García-Gómez, Manuel Valiente

Published in: Angiogenesis | Issue 1/2020

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Abstract

Vascular co-option by brain metastasis-initiating cells has been demonstrated as a critical step in organ colonization. The physical interaction between the cancer cell and the endothelial cell is mediated by integrins and L1CAM and could be involved in aggressive growth but also latency and immune evasion. The key involvement of vascular co-option in brain metastasis has created an emerging field that aims to identify critical targets as well as effective inhibitors with the goal of preventing brain metastases.
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Metadata
Title
Vascular co-option in brain metastasis
Authors
Pedro García-Gómez
Manuel Valiente
Publication date
01-02-2020
Publisher
Springer Netherlands
Published in
Angiogenesis / Issue 1/2020
Print ISSN: 0969-6970
Electronic ISSN: 1573-7209
DOI
https://doi.org/10.1007/s10456-019-09693-x

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