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Surgery Today
Published in: Surgery Today 2/2024

04-06-2023 | Lung Cancer | Original Article

Sex-specific emphysematous changes evaluated by a three-dimensional computed tomography volumetric analysis among patients with smoking histories who underwent resection for lung cancer

Authors: Ashoka Indranatha Wijesinghe, Naohiro Kobayashi, Shinsuke Kitazawa, Naoki Maki, Takahiro Yanagihara, Yusuke Saeki, Shinji Kikuchi, Yukinobu Goto, Hideo Ichimura, Yukio Sato

Published in: Surgery Today | Issue 2/2024

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Abstract

Purpose

The present study evaluated the sex-specific susceptibility to the development of emphysema in patients with smoking histories who underwent lung cancer surgeries.

Methods

Lung cancer patients with smoking histories who underwent lung resection at the University of Tsukuba Hospital, Japan, were enrolled. Radiologic emphysematous changes were analyzed using three-dimensional computed tomography (3D-CT). The volume proportion of emphysematous lung per unit of smoking and the relationship between emphysematous change and clinicopathologic factors were evaluated.

Results

Radiologic emphysematous changes analyzed using 3D-CT per pack-year smoked, defined as the Smoking-Emphysema Index (SEI), were greater in females than males. The difference was more profound in adenocarcinoma patients than in non-adenocarcinoma patients (0.70 ± 2.30 vs. 0.21 ± 0.28, P = 0.037).

Conclusion

Female lung cancer patients are more susceptible to smoking-induced emphysema than males. The SEI may be an effective indicator for evaluating smoking-induced emphysema.
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Metadata
Title
Sex-specific emphysematous changes evaluated by a three-dimensional computed tomography volumetric analysis among patients with smoking histories who underwent resection for lung cancer
Authors
Ashoka Indranatha Wijesinghe
Naohiro Kobayashi
Shinsuke Kitazawa
Naoki Maki
Takahiro Yanagihara
Yusuke Saeki
Shinji Kikuchi
Yukinobu Goto
Hideo Ichimura
Yukio Sato
Publication date
04-06-2023
Publisher
Springer Nature Singapore
Published in
Surgery Today / Issue 2/2024
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-023-02707-8

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