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BMC Anesthesiology
Published in: BMC Anesthesiology 1/2015

Open Access 01-12-2015 | Research article

Long-term treated intensive care patients outcomes: the one-year mortality rate, quality of life, health care use and long-term complications as reported by general practitioners

Authors: Simone Steenbergen, Saskia Rijkenberg, Tamara Adonis, Gerda Kroeze, Ilse van Stijn, Henrik Endeman

Published in: BMC Anesthesiology | Issue 1/2015

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Abstract

Background

The purpose of this study was to determine the one-year mortality rate and its predictors regarding long-term intensive care-treated patients together with their health-related quality of life (HRQL), place of living, healthcare use and long-term complication characteristics after intensive care unit (ICU) discharge.

Methods

A retrospective cohort study was performed in a 20-bed mixed ICU. The patients that were treated for more than 72 h between 2007 and 2012 were included in this study. The one-year mortality rate was calculated, and the characteristics of the ICU survivors that died within one year after ICU discharge were further analysed. For all patients, the Dutch version of the SF-36 questionnaire was used to assess their current HRQL. The results were compared with a normal population. Additionally, patients were questioned about their place of living, and their general practitioners (GPs) were questioned about the patients’ possible long-term complications.

Results

Seven hundred and forty patients were included in this study, and their one-year mortality rate was 28 %, of which half died within the first week after ICU discharge. The one-year mortality rate predictors included age at the time of ICU admission, APACHE IV-predicted mortality score, number of comorbidities and ICU re-admissions. The ICU survivor HRQL was significantly lower compared with the normal population. Half of the patients did not return to their pre-hospital place of living, and numerous possible long-term complications were reported, particularly decreased tolerance, chronic fatigue and processing problems of relatives.

Conclusions

One-year mortality rate of long-term ICU-treated patient was 28 %, and this was predicted by age, disease severity, comorbidities and ICU re-admissions. The ICU survivors reported a lower HRQL, and a minority of these patients returned home directly after hospital discharge; however, GPs reported numerous possible long-term complications.
Literature
1.
Angus DC, Carlet J. Surviving intensive care: a report from the 2002 Brussels Roundtable. Intensive Care Med. 2003;29:368–77.CrossRefPubMed
2.
Desai SV, Law TJ, Needham DM. Long-term complications of critical care. Crit Care Med. 2011;39:371–9.CrossRefPubMed
3.
Herridge MS, Cheung AM, Tansey CM, Matte-Martyn A, Diaz-Granados N, Al Saidi F, et al. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med. 2003;348:683–93.CrossRefPubMed
4.
Brinkman S, de Jonge E, Abu-Hanna A, Arbous MS, de Lange DW, de Keizer NF. Mortality after hospital discharge in ICU patients. Critical Care Med. 2013;41:1229–36.CrossRef
5.
Wright JC, Plenderleith L, Ridley SA. Long-term survival following intensive care: subgroup analysis and comparison with the general population. Anaesthesia. 2003;58:637–42.CrossRefPubMed
6.
Kaarlola A, Tallgren M, Pettila V. Long-term survival, quality of life, and quality-adjusted life-years among critically ill elderly patients. Crit Care Med. 2006;34:2120–6.CrossRefPubMed
7.
Roch A, Wiramus S, Pauly V, Forel JM, Guervilly C, Gainnier M, et al. Long-term outcome in medical patients aged 80 or over following admission to an intensive care unit. Crit Care. 2011.
8.
Mokart D, Etienne A, Esterni B, Brun JP, Chow-Chine L, Sannini A, et al. Critically ill cancer patients in the ICU: short-term outcome and 1-year mortality. Acta Anaesthesiol Scand. 2012;56:178–89.CrossRefPubMed
9.
Douglas SL, Daly BJ, Kelley CG, O’Toole E, Montenegro H. Chronically Critically ill patients: HRQOL and resource use after a disease management intervention. Am J Crit Care. 2007;16:447–57.PubMedPubMedCentral
10.
Aaronson NK, Muller M, Cohen PD, Essink-Bot ML, Fekkes M, Sanderman R, et al. Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic disease populations. J Clin Epidemiol. 1998;51:1055–68.CrossRefPubMed
11.
Zimmerman JE, Kramer AA, McNair DS, Malila FM. Acute Physiology and Chronic Health Evaluation (APACHE) IV: hospital mortality assessment for today’s critically ill patients. Crit Care Med. 2006;34:1297–310.CrossRefPubMed
12.
Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996;22:707–10.CrossRefPubMed
13.
Sandwijk. Licit and Illicit drug use in Amsterdam II. 1994.
14.
Brinkman S, Bakhshi-Raiez F, Abu-Hanna A, de Jonge E, de Keizer NF. Determinants of mortality after hospital discharge in ICU patients: literature review and Dutch cohort study. Crit Care Med. 2013;41:1237–51.CrossRefPubMed
15.
Keenan SP, Dodek P, Chan K, Hogg RS, Craib KJ, Anis AH, et al. Intensive care unit admission has minimal impact on long-term mortality. Crit Care Med. 2002;30:501–7.CrossRefPubMed
16.
Williams TA, Dobb GJ, Finn JC, Knuiman MW, Geelhoed E, Lee KY, et al. Determinants of long-term survival after intensive care. Crit Care Med. 2008;36:1523–30.CrossRefPubMed
17.
Araujo I, Goncalves-Pereira J, Teixeira S, Nazareth R, Silvestre J, Mendes V, et al. Assessment of risk factors for in-hospital mortality after intensive care unit discharge. Biomarkers. 2012;17:180–5.CrossRefPubMed
18.
Azoulay E, Adrie C, De Lassence A, Pochard F, Moreau D, Thiery G, et al. Determinants of postintensive care unit mortality: a prospective multicenter study. Crit Care Med. 2003;31:428–32.CrossRefPubMed
19.
Conti M, Merlani P, Ricou B. Prognosis and quality of life of elderly patients after intensive care. Swiss Med Wkly. 2012;142:w13671.PubMed
20.
21.
Wunsch H, Guerra C, Barnato AE, Angus DC, Li G, Linde-Zwirble WT. Three-year outcomes for medicare beneficiaries who survive intensive care. J Am Med Assoc. 2010;303:849–56.CrossRef
22.
Dick A, Liu H, Zwanziger J, Perencevich E, Furuya EY, Larson E, et al. Long-term survival and healthcare utilization outcomes attributable to sepsis and pneumonia. BMC Health Serv Res. 2012;12:432.CrossRefPubMedPubMedCentral
23.
Oeyen SG, Vandijck DM, Benoit DD, Annemans L, Decruyenaere JM. Quality of life after intensive care: a systematic review of the literature. Crit Care Med. 2010;38:2386–400.CrossRefPubMed
24.
Dowdy DW, Eid MP, Sedrakyan A, Mendez-Tellez PA, Pronovost PJ, Herridge MS, et al. Quality of life in adult survivors of critical illness: a systematic review of the literature. Intensive Care Med. 2005;31:611–20.CrossRefPubMed
25.
Welsh CH, Thompson K, Long-Krug S. Evaluation of patient-perceived health status using the Medical Outcomes Survey Short-Form 36 in an intensive care unit population. Crit Care Med. 1999;27:1466–71.CrossRefPubMed
26.
Wehler M, Geise A, Hadzionerovic D, Aljukic E. Health-related quality of life of patients with multiple organ dysfunction: individual changes and comparison with normative population. Crit Care Med. 2003.
27.
Williams TA, Leslie GD, Brearley L, Dobb GJ. Healthcare utilisation among patients discharged from hospital after intensive care. Anaesth Intensive Care. 2010;38:732–9.PubMed
28.
Lone NI, Seretny M, Wild SH, Rowan KM, Murray GD, Walsh TS. Surviving intensive care: a systematic review of healthcare resource use after hospital discharge*. Crit Care Med. 2013;41:1832–43.CrossRefPubMed
29.
Addington-Hall J, Kalra L. Who should measure quality of life. Britisch Medical Journal. 2001;9:1417–20.CrossRef
30.
Hofhuis JGM, Spronk PE, Stel HF, Schrijvers GJP, Rommes JH, Bakker J. The impact of critical illness on perceived health-related quality of life during ICU treatment, hospital stay and after hospital discharge. Chest. 2008;133:377–85.CrossRefPubMed
31.
Dinglas VD, Gellar J, Colantuoni E, Stan VA, Mendez-Tellez PA, Pronovost PJ, et al. Does intensive care unit severity of illness influence recall of baseline physical function? J Crit Care. 2011;26:634–7.CrossRefPubMedPubMedCentral
32.
McPhail S, Haines T. Response shift, recall bias and their effect on measuring change in health-related quality of life amongst older hospital patients. Health Qual Life Outcomes. 2010;8:65.CrossRefPubMedPubMedCentral
33.
Gifford JM, Husain N, Dinglas VD, Colantuoni E, Needham DM. Baseline quality of life before intensive care: a comparison of patient versus proxy responses. Crit Care Med. 2010;38:855–60.CrossRefPubMedPubMedCentral
Metadata
Title
Long-term treated intensive care patients outcomes: the one-year mortality rate, quality of life, health care use and long-term complications as reported by general practitioners
Authors
Simone Steenbergen
Saskia Rijkenberg
Tamara Adonis
Gerda Kroeze
Ilse van Stijn
Henrik Endeman
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Anesthesiology / Issue 1/2015
Electronic ISSN: 1471-2253
DOI
https://doi.org/10.1186/s12871-015-0121-x

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