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Journal of Gastrointestinal Cancer
Published in: Journal of Gastrointestinal Cancer 2/2018

01-06-2018 | Case Report

Long-Term Survival with Chemoradiation Alone in Locally Advanced Unresectable Gallbladder Cancer: First Case Report of a New Paradigm

Author: Sushma Agrawal

Published in: Journal of Gastrointestinal Cancer | Issue 2/2018

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Excerpt

Gallbladder cancer (GBC) is endemic in North India in the Indo-Gangetic belt and usually presents as unresectable or metastatic disease [1]. Palliative chemotherapy is the only treatment which yields a median survival of 9 months [2]. Unresectable GBCs are those which are involving the portal vein, hepatic artery, or contiguous organs and those with distant nodal disease or metastases. Attempt at neoadjuvant strategies in non-metastatic locally advanced gallbladder cancer shows resectability rates ranging from 15–40% [3, 4]. Survival beyond 25 months has not been reported with this strategy. We report the first case with 8-year-survival after chemoradiation in a woman with locally advanced gallbladder cancer. …
Literature
1.
Three-Year Report of Population Based Cancer Registries 2009–2011, National Cancer Registry Programme (Indian Council of Medical Research), 2013. http://​ncrpindia.​org
2.
Valle J, Wasan H, Palmer DH, et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med. 2010;362(14):1273–81.CrossRefPubMed
3.
Sirohi B, Mitra A, Jagannath P, et al. Neoadjuvant chemotherapy in patients with locally advanced gallbladder cancer. Future Oncol. 2015;11(10):1501–9.CrossRefPubMed
4.
Agrawal S, Mohan L, Mourya C, et al. Radiologic downstaging with neoadjuvant therapy in locally advanced gallbladder cancer. Asian Pac J Cancer Prev. 2016;17(4):2137–40.CrossRefPubMed
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Beets GL, Figueiredo NL, Habr-Gama A, van de Velde CJ. A new paradigm for rectal cancer: organ preservation: introducing the International Watch & Wait Database (IWWD). Eur J Surg Oncol. 2015;Dec;41(12):1562–4.CrossRef
6.
Engineer R, Goel M, Chopra S, et al. Neoadjuvant chemoradiation followed by surgery for locally advanced gallbladder cancers: a new paradigm. Ann Surg Oncol. 2016;23(9):3009–15.CrossRefPubMed
7.
Kato A, Shimizu H, Ohtsuka M, et al. Surgical resection after downsizing chemotherapy for initially unresectable locally advanced biliary tract cancer: a retrospective single-center study. Ann Surgical Oncol. 2013;20:318–24.CrossRef
Metadata
Title
Long-Term Survival with Chemoradiation Alone in Locally Advanced Unresectable Gallbladder Cancer: First Case Report of a New Paradigm
Author
Sushma Agrawal
Publication date
01-06-2018
Publisher
Springer US
Published in
Journal of Gastrointestinal Cancer / Issue 2/2018
Print ISSN: 1941-6628
Electronic ISSN: 1941-6636
DOI
https://doi.org/10.1007/s12029-016-9893-6

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Obesity Clinical Trial Summary

At a glance: The STEP trials

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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

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