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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 1/2013

01-01-2013 | Hepatobiliary Tumors

Surgical Resection after Downsizing Chemotherapy for Initially Unresectable Locally Advanced Biliary Tract Cancer: A Retrospective Single-center Study

Authors: Atsushi Kato, MD, PhD, Hiroaki Shimizu, MD, PhD, Masayuki Ohtsuka, MD, PhD, Hiroyuki Yoshidome, MD, PhD, Hideyuki Yoshitomi, MD, PhD, Katsunori Furukawa, MD, PhD, Dan Takeuchi, MD, PhD, Tsukasa Takayashiki, MD, PhD, Fumio Kimura, MD, PhD, Masaru Miyazaki, MD, PhD

Published in: Annals of Surgical Oncology | Issue 1/2013

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Abstract

Background

Surgical resection is the only method for curative treatment of biliary tract cancer (BTC). Recently, an improved efficacy has been revealed in patients with initially unresectable locally advanced BTC to improve the prognosis by the advent of useful cancer chemotherapy. The aim of this study was to evaluate the effect of downsizing chemotherapy in patients with initially unresectable locally advanced BTC.

Methods

Initially unresectable locally advanced cases were defined as those in which therapeutic resection could not be achieved even by proactive surgical resection. Gemcitabine was administered intravenously once a week for 3 weeks followed by 1 week’s respite. Patients whose disease responded to chemotherapy were reevaluated to determine whether their tumor was resectable.

Results

Chemotherapy with gemcitabine was provided to 22 patients with initially unresectable locally advanced BTC. Tumor was significantly downsized in nine patients, and surgical resection was performed in 8 (36.4%) of 22 patients. Surgical resection resulted in R0 resection in four patients and R1 resection in four patients. Patients who underwent surgical resection had a significantly longer survival compared with those unable to undergo surgery.

Conclusions

Preoperative chemotherapy enables the downsizing of initially unresectable locally advanced BTC, with radical resection made possible in a certain proportion of patients. Downsizing chemotherapy should be proactively carried out as a multidisciplinary treatment strategy for patients with initially unresectable locally advanced BTC with the aim of expanding the surgical indication.
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Metadata
Title
Surgical Resection after Downsizing Chemotherapy for Initially Unresectable Locally Advanced Biliary Tract Cancer: A Retrospective Single-center Study
Authors
Atsushi Kato, MD, PhD
Hiroaki Shimizu, MD, PhD
Masayuki Ohtsuka, MD, PhD
Hiroyuki Yoshidome, MD, PhD
Hideyuki Yoshitomi, MD, PhD
Katsunori Furukawa, MD, PhD
Dan Takeuchi, MD, PhD
Tsukasa Takayashiki, MD, PhD
Fumio Kimura, MD, PhD
Masaru Miyazaki, MD, PhD
Publication date
01-01-2013
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 1/2013
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-012-2312-8

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