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Clinical Pharmacokinetics
Published in: Clinical Pharmacokinetics 8/2008

01-08-2008 | Review Article

Population Pharmacokinetics and Pharmacodynamics for Treatment Optimization in Clinical Oncology

Authors: Ms Anthe S. Zandvliet, Jan H. M. Schellens, Jos H. Beijnen, Alwin D. R. Huitema

Published in: Clinical Pharmacokinetics | Issue 8/2008

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Abstract

Population pharmacokinetic and pharmacodynamic analysis is an important tool to support optimal treatment in clinical oncology. The population approach is suitable to explain variability between patients and to establish relationships between drug exposure and a relevant pharmacodynamic parameter. This can facilitate the selection of dosing schedules, the development of strategies for dose individualization and the application of therapeutic drug monitoring of anticancer agents. This review discusses the role of population pharmacokinetics and pharmacodynamics in clinical oncology to enhance the efficiency of drug development and to support the development of safe and effective dosing regimens for optimal treatment of cancer patients. An overview of published population studies of investigational anticancer agents and established treatment regimens is presented.
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Metadata
Title
Population Pharmacokinetics and Pharmacodynamics for Treatment Optimization in Clinical Oncology
Authors
Ms Anthe S. Zandvliet
Jan H. M. Schellens
Jos H. Beijnen
Alwin D. R. Huitema
Publication date
01-08-2008
Publisher
Springer International Publishing
Published in
Clinical Pharmacokinetics / Issue 8/2008
Print ISSN: 0312-5963
Electronic ISSN: 1179-1926
DOI
https://doi.org/10.2165/00003088-200847080-00001