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Drugs
Published in: Drugs 18/2005

01-12-2005 | Leading Article

Calcitonin Gene-Related Peptide Antagonists as Treatments of Migraine and Other Primary Headaches

Author: Professor Peter J. Goadsby

Published in: Drugs | Issue 18/2005

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Abstract

Calcitonin gene-related peptide (CGRP) is a potent neuromodulator that is expressed in the trigeminovascular system and is released into the cranial circulation in various primary headaches. CGRP is released in migraine, cluster headache and paroxysmal hemicrania. The blockade of its release is associated with the successful treatment of acute migraine and cluster headache. CGRP receptor blockade has recently been shown to be an effective acute anti-migraine strategy and is non-vasoconstricting in terms of the mechanism of action. The prospect of a non-vasoconstricting therapy for acute migraine offers a real opportunity to patients, and perhaps more importantly, provides a therapeutic rationale to reinforce migraine as a neurological disorder.
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Metadata
Title
Calcitonin Gene-Related Peptide Antagonists as Treatments of Migraine and Other Primary Headaches
Author
Professor Peter J. Goadsby
Publication date
01-12-2005
Publisher
Springer International Publishing
Published in
Drugs / Issue 18/2005
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI
https://doi.org/10.2165/00003495-200565180-00002

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