Published in:
01-12-2005 | Adis Drug Profile
Tigecycline
A Viewpoint by Mark H. Wilcox
Author:
Mark H. Wilcox
Published in:
Drugs
|
Issue 18/2005
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Excerpt
Tigecycline represents a new class of antibiotics, the glycylcyclines, which have many of the advantages of tetracyclines, such as good tissue penetration. Additionally, it has expanded broad spectrum activity that includes antimicrobial-resistant pathogens, e.g. methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci, multidrug-resistant Streptococcus pneumoniae, extended-spectrum β-lactamase-producing Gram-negative bacteria, Acinetobacter baumannii, and bacteria with tetracycline resistance determinants. Tigecycline is not, however, active against some bacteria, such as Proteus, Providencia and Pseudomonas species. …
