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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 1/2020

01-01-2020 | Melanoma | Melanoma

The Landmark Series: Non-melanoma Skin Cancers

Authors: Ann Y. Lee, MD, Russell S. Berman, MD

Published in: Annals of Surgical Oncology | Issue 1/2020

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Abstract

Surgery with or without radiation has always been the mainstay of treatment for patients with non-melanoma skin cancers, including basal cell carcinoma, squamous cell carcinoma, and Merkel cell carcinoma. Until recently, there were no effective systemic therapies for patients with advanced disease. This review will focus on the landmark clinical trials that led to Food and Drug Administration (FDA) approval of Vismodegib for advanced basal cell carcinoma (ERIVANCE BCC) and pembrolizumab for advanced Merkel cell carcinoma (KEYNOTE-017). These trials have not only changed the landscape for patients with metastatic disease but also notably for patients with locally advanced disease that is either unresectable or resectable with high morbidity. Additional mention is made for the clinical trial that led to FDA approval of cemiplimab for advanced cutaneous squamous cell carcinoma (EMPOWER-CSCC-1), which is already changing practice patterns, but for which longer-term data are still needed.
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Metadata
Title
The Landmark Series: Non-melanoma Skin Cancers
Authors
Ann Y. Lee, MD
Russell S. Berman, MD
Publication date
01-01-2020
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 1/2020
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-019-07831-9

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