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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 9/2019

01-09-2019 | Esophagus Resection | Gastrointestinal Oncology

The Combination of Respiratory Comorbidity and Neoadjuvant Chemoradiotherapy May Double the Risk of Anastomotic Leaks After Esophagectomy: Do We Know Enough to Tailor Neoadjuvant Therapies, or Take Other Preemptive Measures in High-Risk Patients?

Author: Magnus Nilsson, MD, PhD

Published in: Annals of Surgical Oncology | Issue 9/2019

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Excerpt

The article by Klevebro et al., “Cardiorespiratory comorbidity and postoperative complications following esophagectomy: A European multicenter cohort study,”1 published in this issue of Annals of Surgical Oncology, provides new and important insights regarding the impact of comorbidity on complications after esophagectomy, and intriguingly also suggests that there is an interaction between respiratory complications and the type of neoadjuvant therapy. In fact, this study shows a significantly increased risk of anastomotic leaks and pulmonary complications in patients with respiratory comorbidity after neoadjuvant chemoradiotherapy, but not after neoadjuvant chemotherapy or in patients who went straight to surgery. …
Literature
1.
Klevebro F, Elliot JA, Slaman A, Vermeulen BD, Kamiya S, Rosman C, Gisbertz SS, Boshier PR, Reynolds JV, Rouvelas I, Hanna GB, van Berge Henegouwen MI, Markar SR. Cardiorespiratory comorbidity and postoperative complications following esophagectomy: a European multicenter cohort study. Ann Surg Oncol. 2019. https://​doi.​org/​10.​1245/​s10434-019-07478-6.
2.
Reynolds JV, Preston SR, O’Neill B, et al. ICORG 10-14: NEOadjuvant trial in Adenocarcinoma of the Esophagus and oesophagoGastric junction International Study (Neo-AEGIS). BMC Cancer. 2017;17(1):401.CrossRefPubMedPubMedCentral
3.
Hoeppner J, Lordick F, Brunner T, et al. ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT0250986). BMC Cancer. 2016;16:503.CrossRefPubMedPubMedCentral
4.
Metadata
Title
The Combination of Respiratory Comorbidity and Neoadjuvant Chemoradiotherapy May Double the Risk of Anastomotic Leaks After Esophagectomy: Do We Know Enough to Tailor Neoadjuvant Therapies, or Take Other Preemptive Measures in High-Risk Patients?
Author
Magnus Nilsson, MD, PhD
Publication date
01-09-2019
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 9/2019
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-019-07485-7

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